全文获取类型
收费全文 | 8742篇 |
免费 | 468篇 |
国内免费 | 67篇 |
专业分类
耳鼻咽喉 | 104篇 |
儿科学 | 119篇 |
妇产科学 | 74篇 |
基础医学 | 1148篇 |
口腔科学 | 214篇 |
临床医学 | 478篇 |
内科学 | 2213篇 |
皮肤病学 | 234篇 |
神经病学 | 721篇 |
特种医学 | 411篇 |
外科学 | 1662篇 |
综合类 | 49篇 |
一般理论 | 1篇 |
预防医学 | 202篇 |
眼科学 | 79篇 |
药学 | 447篇 |
中国医学 | 22篇 |
肿瘤学 | 1099篇 |
出版年
2024年 | 9篇 |
2023年 | 87篇 |
2022年 | 147篇 |
2021年 | 297篇 |
2020年 | 135篇 |
2019年 | 215篇 |
2018年 | 258篇 |
2017年 | 205篇 |
2016年 | 275篇 |
2015年 | 266篇 |
2014年 | 326篇 |
2013年 | 353篇 |
2012年 | 569篇 |
2011年 | 650篇 |
2010年 | 372篇 |
2009年 | 347篇 |
2008年 | 512篇 |
2007年 | 598篇 |
2006年 | 557篇 |
2005年 | 578篇 |
2004年 | 510篇 |
2003年 | 470篇 |
2002年 | 490篇 |
2001年 | 90篇 |
2000年 | 70篇 |
1999年 | 94篇 |
1998年 | 107篇 |
1997年 | 115篇 |
1996年 | 73篇 |
1995年 | 83篇 |
1994年 | 37篇 |
1993年 | 53篇 |
1992年 | 40篇 |
1991年 | 34篇 |
1990年 | 40篇 |
1989年 | 25篇 |
1988年 | 29篇 |
1987年 | 25篇 |
1986年 | 14篇 |
1985年 | 12篇 |
1984年 | 8篇 |
1983年 | 14篇 |
1982年 | 12篇 |
1981年 | 10篇 |
1980年 | 10篇 |
1979年 | 10篇 |
1978年 | 11篇 |
1975年 | 4篇 |
1974年 | 7篇 |
1967年 | 5篇 |
排序方式: 共有9277条查询结果,搜索用时 11 毫秒
91.
Shiomi H Hase T Matsuno S Izumi M Tatsuta T Ito F Kishida A Tani T Kodama M 《Surgery today》1999,29(12):1280-1284
An 18-year-old male was admitted to our Emergency Department with a traumatic abdominal wall hernia (TAWH) of the left lower
quadrant (LLQ) after suffering hypogastric blunt injury and urogenital lacerations in a motorcycle accident. Upright chest
X-ray showed a small amount of right infradiaphragmatic free air, and a computed tomographic (CT) scan demonstrated an abdominal
wall hernia. At surgery, no impairment was found in the digestive tract, and an abdominal herniorrhaphy was performed. It
is suggested that the free air had passed through a connection between the scrotal laceration and the contralateral abdominal
defect via the subcutaneous space and was palpated as emphysema. This is a new type of TAWH, which suggests that blunt abdominal
trauma may result in negative pressure in the subcutaneous and peritoneal cavity, and this could reflect the pathophysiology
of TAWH. 相似文献
92.
Sakakibara H Zhu SK Furuta M Kondo T Miyao M Yamada S Hideaki T 《Environmental health and preventive medicine》1996,1(3):114-118
Factors associated with knee pain were investigated using 871 self-administered questionnaires (405 men and 466 women) from
residents aged over 30 years in a rural area of Japan. The prevalence of knee pain increased with age, particularly in women
over 50. It was significantly higher in women than in men. Body mass index (BMI) was significantly related to knee pain in
women, though not in men. With reference to occupational factors, frequent heavy lifting on the job was significantly associated
with knee pain in both men and women, whereas job-related standing and walking showed no such relationship. As for living
conditions, residence on rather steep mountain slopes and the habit of sitting on Japanese tatami mats were significant factors
related to knee pain in men, but not in women. There was no association of knee pain with the style of toilet (Japanese or
Western). After controlling for all significant factors by multiple logistic regression analysis, age, heavy lifting, and
residence on steep slopes were found to be independent factors related to knee pain in men; and age, BMI, and heavy lifting
were the factors in women. 相似文献
93.
Masashi Takamatsu Mitsuru Ohata Kazuhiko Sakamoto Yasuyuki Searashi Kunihiko Takeda Hideaki Suzuki Hisato Nakajima Masayoshi Yamauchi Ken Hokkyo Gotaro Toda Noritoshi Shinkai 《Nihon Arukōru Yakubutsu Igakkai zasshi》2003,38(6):492-497
A case of female alcoholic who developed liver cirrhosis with small amounts of alcohol by the common use of contraceptive agent was reported. A case was a 33-year-old female who had complained of systemic edema and jaundice. She had been drinking alcohol, while she had been taking the contraceptive agent from 20-year-old. On admission, she had a large amount of ascites with jaundice. She was diagnosed as liver cirrhosis and hepatic failure by CT scanning of abdomen and laboratory data. Her condition was temporarily improved by the abstinence and the treatment. Since she drank under hospitalization, she had to change the hospital and died after 2 months. She had been drinking for only 10 years. Her cumulative alcohol intake was also very small. She may have developed alcoholic cirrhosis with small amount of alcohol because of common use of contraceptive agent with drinking. 相似文献
94.
95.
Keiichi Ichimura Masashi Sugasawa Ken-ichi Nibu Esao Takasago Kenji Hasezawa 《Auris, nasus, larynx》1997,24(4):391-397
We sometimes experience patients with persistent or progressive arytenoid edema, among which residual or recurrent cancer is often accompanied. Because it is difficult to distinguish tumour rest or recurrence from normal tissue sequelae in the early period after irradiation, it is important to know both the contributing factors for arytenoid edema, and the incidence of residual or recurrent tumours in patients with postirradiation laryngeal edema. We therefore reviewed the charts of 67 patients with early laryngeal carcinoma who had received a curative dose of irradiation in the last 5 years. Fourteen patients (20.9%) had moderate or severe laryngeal edema persisting for or developing at more than 3 months after completion of a course of definitive radiotherapy. The incidence was highest in supraglottic T2 disease, followed by glottic T2 tumour. Of the 14 patients with edema, six (42.9%) had persistent or recurrent disease. The primary disease was uncontrolled in 18 patients, 17 of whom received successful salvage surgery. In patients without residual tumours, the edema was usually moderate and resolved within a year, although four patients had chronic edema lasting more than a year after treatment. All four had supraglottic T2 lesions and received 70 Gy of X-ray. We also reviewed, for sake of comparison, the records of 38 patients treated with radiotherapy at doses of more than 40 Gy between l975 and 1980, when endoscopic microsurgery for laryngeal cancer was introduced as a primary part of treatment. The incidence of persistent or late developed edema over the period, though not significant, was 36.8%: nearly twice that of the last 5 years. Microscopic endolaryngeal surgical procedures seem to have been a causal factor for edema in this period. 相似文献
96.
Fujio Kakuya Masashi Takase Noriyuki Ishii Mayumi Kajino Tokitsugi Hayashi Kazutoshi Miyamoto Senichi Muraki Jun Iwamoto Akimasa Okuno 《Pediatrics international》1998,40(2):155-158
Abstract The delivery of nitric oxide (NO) via a nasopharyngeal tube is an alternative to endotracheal intubation. A male infant with end-stage pulmonary hypertension (PH) due to a severe hypoplastic lung developed a PH crisis on day 145 and received NO inhalation via a nasopharyngeal tube. Clinical improvement was maintained for 7 days with18–22ppm NO inhalation. The patient remained in close physical contact with his parents without the use of sedation. Blood methemoglobin levels remained below 1%. The environmental NO levels were less than 0.06 ppm and NO2 less than 0.3 ppm throughout the treatment, well within the safety margin. On day 152, the patient succumbed to hypoxemia and heart failure. The use of a nasopharyngeal NO delivery system without sedation, as an alternative to endotracheal intubation with sedation, was a practical method in treating a patient with PH while maintaining a certain quality of life for the patient and the family. 相似文献
97.
Sequence Analysis of Genes Encoding Rodent Homologues of the Human Tumor-rejection Antigen SART-1 总被引:2,自引:0,他引:2
Masashi Gotoh Shigeki Shichijo Tomoaki Hoshino Yasuhisa Imai Toshihiro Imaizumi Yoshiko Inoue Hideo Takasu Takashi Yamaoka Kyogo Itoh 《Cancer science》1998,89(8):849-854
Human SART-1 ( hSART-1 ) gene encodes a 125 kD protein with a leucine-zipper motif expressed in the nucleus of all proliferating cells, and a 43 kD protein expressed in the cytosol of most epithelial cancers. In this study, two rodent genes ( rSART-1 and mSART-1 ) homologous to hSART-1 were cloned from cDNA libraries of murine brain and a rat tumor cell line, respectively. mSART-1 and rSART-1 were highly homologous to hSART-1 with 86% and 84% identity at the nucleotide level, and 95% and 91% at the protein level, respectively. The leucine zipper domain and two basic amino acid portions that bind DNA, as well as peptide sequences recognized by human cyto-toxic T lymphocytes (CTLs), were all conserved in these rodent genes. Nuclear protein homologous to the 125 kD hSART-1800 protein, but not to the 43 kD cytosol SART-1259 protein, was detectable with specific antibody in the nuclear fractions of rodent tumor cell lines, and normal rodent fetal liver and testis. These rodent genes should be a novel tool for studies on the biological roles of the SART-1 gene, and also in the construction of animal models of specific immuno-therapy using SART-1 gene products. 相似文献
98.
Takuji Suzuki Tatsuro Fukuhara Masashi Tanaka Akira Nakamura Kenichi Akiyama Tomohiro Sakakibara Daizo Koinuma Toshiaki Kikuchi Ryushi Tazawa Makoto Maemondo Koichi Hagiwara Yasuo Saijo Toshihiro Nukiwa 《Clinical cancer research》2005,11(1):58-66
Cancer immunotherapy by fusion of antigen-presenting cells and tumor cells has been shown to induce potent antitumor immunity. In this study, we characterized syngeneic and allogeneic, murine macrophage/dendritic cell (DC)-cancer fusion cells for the antitumor effects. The results showed the superiority of allogeneic cells as fusion partners in both types of antigen-presenting cells in an in vivo immunotherapy model. A potent induction of tumor-specific CTLs was observed in these immunized conditions. In addition, the immunization with DC-cancer fusion cells was better than that with macrophage-cancer fusion cells. Both syngeneic and allogeneic DC-cancer fusion cells induced higher levels of IFN-gamma production than macrophage-cancer fusion cells. Interestingly, allogeneic DC-cancer fusion cells were superior in that they efficiently induced Th1-type cytokines but not the Th2-type cytokines interleukin (IL)-10 and IL-4, whereas syngeneic DC-cancer fusion cells were powerful inducers of both Th1 and Th2 cytokines. These results suggest that allogeneic DCs are suitable as fusion cells in cancer immunotherapy. To further enhance the antitumor immunity in the clinical setting, we prepared DCs fused with IL-12 gene-transferred cancer cells and thus generated IL-12-secreting DC-cancer fusion cells. Immunization with these gene-modified DC-cancer fusion cells was able to elicit a markedly enhanced antitumor effect in the in vivo therapeutic model. This novel IL-12-producing fusion cell vaccine might be one promising intervention for future cancer immunotherapy. 相似文献
99.
Shin-ichi Fukumoto Naoko Yamauchi Hisashi Moriguchi Yoshitaka Hippo Akira Watanabe Junji Shibahara Hirokazu Taniguchi Shumpei Ishikawa Hirotaka Ito Shogo Yamamoto Hiroko Iwanari Mitsugu Hironaka Yuichi Ishikawa Toshiro Niki Yasunori Sohara Tatsuhiko Kodama Masaharu Nishimura Masashi Fukayama Hirotoshi Dosaka-Akita Hiroyuki Aburatani 《Clinical cancer research》2005,11(5):1776-1785
PURPOSE: Squamous cell carcinoma (SCC) and adenocarcinoma of the lung are currently subject to similar treatment regimens despite distinct differences in histology and epidemiology. The aim of this study is to identify a molecular target with diagnostic and therapeutic values for SCC. EXPERIMENTAL DESIGN: Genes specifically up-regulated in SCC were explored through microarray analysis of 5 SCCs, 5 adenocarcinomas, 10 small cell lung carcinomas, 27 normal tissues, and 40 cancer cell lines. Clinical usefulness of these genes was subsequently examined mainly by immunohistochemical analysis. RESULTS: Seven genes, including aldo-keto reductase family 1, member B10 (AKR1B10), were identified as SCC-specific genes. AKR1B10 was further examined by immunohistochemical analysis of 101 non-small cell lung carcinomas (NSCLC) and its overexpression was observed in 27 of 32 (84.4%) SCCs and 19 of 65 (29.2%) adenocarcinomas. Multiple regression analysis showed that smoking was an independent variable responsible for AKR1B10 overexpression in NSCLCs (P < 0.01) and adenocarcinomas (P < 0.01). AKR1B10 staining was occasionally observed even in squamous metaplasia, a precancerous lesion of SCC. CONCLUSION: AKR1B10 was overexpressed in most cases with SCC, which is closely associated with smoking, and many adenocarcinoma cases of smokers. These results suggest that AKR1B10 is a potential diagnostic marker specific to smokers' NSCLCs and might be involved in tobacco-related carcinogenesis. 相似文献
100.
Takeshi Yoshida Go Suzuki Masashi Nibuya Shin-ya Sano Soichiro Nomura 《Nihon shinkei seishin yakurigaku zasshi》2004,24(1):29-31
Although still controversial, iron deficiency has been indicated as one of the risk factors for developing neuroleptic-induced extrapyramidal symptoms (EPSs), including akathisia, dystonia, and neuroleptic malignant syndrome. Here we report our experience of iron supplementation and alternating neuroleptics for treating Parkinsonism in a schizophrenic female patient having severe iron deficient anemia. 相似文献