全文获取类型
收费全文 | 16622篇 |
免费 | 826篇 |
国内免费 | 149篇 |
专业分类
耳鼻咽喉 | 167篇 |
儿科学 | 321篇 |
妇产科学 | 266篇 |
基础医学 | 1774篇 |
口腔科学 | 340篇 |
临床医学 | 1143篇 |
内科学 | 4467篇 |
皮肤病学 | 298篇 |
神经病学 | 1067篇 |
特种医学 | 702篇 |
外科学 | 2950篇 |
综合类 | 74篇 |
一般理论 | 1篇 |
预防医学 | 500篇 |
眼科学 | 262篇 |
药学 | 1105篇 |
中国医学 | 34篇 |
肿瘤学 | 2126篇 |
出版年
2023年 | 90篇 |
2022年 | 221篇 |
2021年 | 397篇 |
2020年 | 238篇 |
2019年 | 318篇 |
2018年 | 368篇 |
2017年 | 316篇 |
2016年 | 355篇 |
2015年 | 396篇 |
2014年 | 492篇 |
2013年 | 584篇 |
2012年 | 942篇 |
2011年 | 1002篇 |
2010年 | 600篇 |
2009年 | 488篇 |
2008年 | 838篇 |
2007年 | 923篇 |
2006年 | 920篇 |
2005年 | 957篇 |
2004年 | 891篇 |
2003年 | 936篇 |
2002年 | 907篇 |
2001年 | 419篇 |
2000年 | 378篇 |
1999年 | 389篇 |
1998年 | 201篇 |
1997年 | 157篇 |
1996年 | 144篇 |
1995年 | 116篇 |
1994年 | 123篇 |
1993年 | 105篇 |
1992年 | 232篇 |
1991年 | 223篇 |
1990年 | 199篇 |
1989年 | 216篇 |
1988年 | 185篇 |
1987年 | 163篇 |
1986年 | 151篇 |
1985年 | 121篇 |
1984年 | 89篇 |
1983年 | 81篇 |
1982年 | 39篇 |
1979年 | 103篇 |
1978年 | 53篇 |
1977年 | 40篇 |
1973年 | 39篇 |
1971年 | 41篇 |
1970年 | 36篇 |
1969年 | 49篇 |
1966年 | 39篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
71.
Chiaki Isobe Takahiko Murata Chigumi Sato Yasuo Terayama 《Journal of clinical neuroscience》2007,14(4):340-343
The concentrations of oxidized coenzyme Q-10 (CoQ-10) and reduced CoQ-10 in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) was examined in order to determine whether the balance in oxidized and reduced CoQ-10 is related to the pathogenesis of PD. The percentage of oxidized/total CoQ-10 (%CoQ-10) in the CSF was significantly higher in the untreated PD group (80.3+/-17.9%) compared to the normal control group (68.2+/-20.4%) (p<0.05). The %CoQ-10 in the CSF of PD patients showed significant negative correlation with the duration of illness. These findings in living patients provide in vivo evidence for a possible role for %CoQ-10 in the pathogenesis in the early stages of PD development. 相似文献
72.
Kiyoaki Takaba Masaki Aota Hiroyuki Koike Yutaka Konishi 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(4):194-197
Aneurysm of the innominate artery is uncommon compared with other peripheral aneurysms, and holds the potential for rupture,
embolization, or thrombosis as well as various complications caused by compression to the adjacent structures. The most effective
treatment for this condition is surgical resection, but the earlier reports described high mortality rates. We report the
case of an 83-year-old asymptomatic woman with an aneurysm in the innominate artery, which was successfully resected and repaired
with the use of modern surgical techniques of hypothermic circulatory arrest and selective cerebral perfusion. Aggressive
surgical intervention should be employed despite the fact that a patients is asymptomatic. 相似文献
73.
Hiroyuki Sakai Masaki Ibe Hidetoshi Takahashi Shinobu Matsuo Kensaku Okamoto Isao Makino Yukio Oomori Hajime Iizuka 《The Journal of dermatology》1996,23(1):42-46
Langerhans cell histiocytosis is currently regarded as a reactive proliferative process of Langerhans cells rather than a malignancy. The disease is characterized by Langerhans cell infiltration of skin, lung, bone and other organs. We report a 74-year-old man with Langerhans cell histiocytosis who had generalized hemorrhagic and crusted papules. He also had diabetes insipidus. Because he did not have any severe constitutional symptoms or failure of vital organs, we applied topical PUVA treatment to his skin lesions, which responded well to the therapy. Diabetes insipidus, however, remained, in spite of X ray radiotherapy for the pituiary lesion. 相似文献
74.
S. Murata H. Asaba K. Hiraishi I. Narabayashi H. Naritomi T. Sakai 《Journal of neuroimaging》1993,3(2):128-131
Four patients who had carbon monoxide intoxication were examined by brain magnetic resonance imaging (MRI) and computed tomography (CT). Three were unconscious in the acute stage of intoxication. On regaining consciousness. neuropsychological symptoms and signs remained. In these patients, T2-weighted MRI demonstrated hyperintensity lesions in the cerebral cortex, most prominent in the watershed zone. The fourth patient had only memory disturbance and was not unconscious during the acute intoxication. The T1-weighted MRI showed hyperintensity in the bilateral pallidal regions. MRI demonstrated lesions more clearly than did CT. 相似文献
75.
Y Iikura M Baba H Mikawa S Nishima K Maeda T Akasaka T Masaki M Arita H Niiya N Koya 《Arerugī》1991,40(2):132-140
Many asthmatic children have experienced atopic dermatitis in their younger days. As it is very difficult to cure childhood asthma we attempted to determine the anti-allergic drug effects in preventing the development of asthma by using ketotifen on atopic dermatitis patients. The study was designed as a placebo controlled double blind trial of 128 atopic dermatitis patients aged from 2-34 months. 91 patients were given complete analysis in the study, 33 patients were given only a safety rate and 4 patients were dropped. The 91 patients were followed for 52 weeks. Our primary finding was that the development of bronchial asthma was inhibited in the ketotifen group compared to the placebo controlled group with a statistically significant degree (p less than 0.001). We also found that clinical symptoms of atopic dermatitis were significantly improved in the ketotifen group (p less than 0.001). Only 5 patients complained of mild side effects. 相似文献
76.
77.
H Fukui H Ide F Hanyu H Ikemoto N Okushima Y Murata Y Sato A Yamada 《Gan to kagaku ryoho. Cancer & chemotherapy》1987,14(4):1106-1110
Subrenal Capsule Assay (SRCA) as a chemosensitivity test was performed on 14 esophageal squamous cell carcinomas in order to select a more effective form of chemotherapy. Of the 14 assays, 12 were evaluable. Mice were treated with anticancer agents (e.g. Cisplatin, Bleomycin, Methotrexate, Vindesine) on days 1 and 3 after transplantation, and on day 6, the sensitivities were determined. Fresh esophageal cancers yielded an evaluable assay rate of 74%. The implant grew progressively for six days in the remaining group of control mice. Histologically, host cell infiltration at the border of the implant was observed from day 3 after transplantation, and cells had degenerated or had been partially replaced by scar tissue by day 6. The results of chemosensitivity tests differed according to the anticancer agent used or from case to case. Clinically, correspondence between the assay results and clinical results was obtained in 5 out of 7 cases. SRCA is a new promising chemosensitivity test which is clinically useful, and the present results indicated the feasibility of its use in developing an effective chemotherapy for esophageal cancer. 相似文献
78.
Haruhiko Ogawa Masaki Fujimura Motoyasu Saito Tamotsu Matsuda Nobuaki Akao Kaoru Kondo 《Clinical autonomic research》1994,4(1-2):19-28
Eosinophilic bronchitis without asthma can cause a persistent non-productive cough which is resistant to bronchodilator therapy. To understand the mechanism of the cough in this disorder, an animal model of eosinophilic bronchitis was developed. Guinea-pigs were treated with transnasal administration of polymyxin B or saline twice a week for 3 weeks. The number of eosinophils in bronchoalveolar lavage fluid increased in polymyxin B-treated animals when compared with those treated with saline. In addition, histological examination showed that the number of eosinophils infiltrated into the tracheal epithelium increased; injury to the tracheal epithelium was greater in polymyxin B-treated animals. The numbers of coughs induced by saline and each concentration of capsaicin (10–18, 10–16, 10–14M) were greater in the polymyxin B-treated animals. FK-224 (a neurokinin receptor antagonist) decreased the heightened cough reflex in this animal model of eosinophilic bronchitis. These findings suggest that neuropeptides, and particularly neurokinins, are involved in the heightened cough receptor sensitivity in eosinophilic bronchitis without asthma. This has implications for better understanding of this disorder and its treatment. 相似文献
79.
Mariko Kobayashi Yukihiro Takahashi Makoto Ando Naoki Wada Masamitsu Murata Toshio Kikuchi 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(12):635-637
A 6 month-old male infant (weight: 4.5 kg) with congenital aortic stenosis underwent aortic valve replacement with a pulmonary
autograft (Ross procedure). The right ventricular outflow tract (RVOT) was reconstructed with a polytetrafluoroethylene (PTFE)-valved
equine pericardial conduit. At the age of 5, re-RVOT reconstruction with an equine pericardial patch bearing a PTFE monocusp
was required because of severe pulmonary stenosis resistant to 2 attempts of percutaneous transluminal pulmonary valvotomy.
Currently, at the age of 8, the degree of aortic regurgitation is trivial and the pulmonary autograft is free of functional
deterioration despite somatic growth. 相似文献
80.
Masaki Ando Tsuguo Igari Seiichi Ando Hirono Satokawa Hitoshi Yokoyama 《Annals of thoracic and cardiovascular surgery》2004,10(1):47-50
A 31-year-old adult with an aortico-left ventricular tunnel (ALVT) arising from the right aortic sinus is reported. Preoperative transesophageal echocardiography demonstrated a ruptured sinus of Valsalva with severe aortic valve regurgitation which originated from the right coronary sinus entering the outlet portion of the left ventricular outflow tract. Operation revealed the aortic entrance of the tunnel was above the right coronary sinus. Direct closure of the orifice of the tunnel using three stitches of 4-0 polypropylene with felt and aortic valve replacement (AVR) was performed. At 10-month follow-up the patient is asymptomatic and receiving no oral medications except anticoagulants. We believe this to be the oldest case of ALVT managed with AVR. 相似文献