Combination therapy of trichloroacetic acid,human autologous fibroblast injection and fibroblast seeded microfibrous collagen scaffold as a novel treatment for osteomyelitis diabetic foot ulcer

A severe complication associated with diabetes is diabetic foot ulcer (DFU). Most patients with DFU require amputation. Although treatment of non-healing diabetic ulcers is challenging, the use of novel therapies can be effective. In this report, we present the case of a woman with type 2 diabetes with DFU-related osteomyelitis, who was treated with a combination therapy of trichloroacetic acid, calcium alginate and foam dressings, human autologous fibroblast injection, and a fibroblast cell-seeded collagen scaffold. The results showed the positive effects of combination therapy on DFU. In the initial treatment, the wound area was measured to be 14 × 7 cm², with a depth of 4 cm. After 6 months, the wound was measured to be 1.5 cm², showing a 90% reduction of the wound area. Overall, this combination therapy was highly effective in the treatment of DFU-related osteomyelitis, and could markedly prevent amputation among DFU patients.     

Psychiatric Symptoms Associated with Oocyte-Donation

Oocyte-donation is generally safe but may exacerbate psychiatric symptoms in some women. In this prospective study 63 oocyte-donating women and, as a control group, 63 women providing their own oocytes for in vitro fertilization (in couples with male infertility) were evaluated pre- and post-ovulation-induction in regard to hypochondriasis, anxiety, social impairment, and depression. The mean hypochondriasis score for oocyte-donators was significantly lower than for women providing their own oocytes, prior to ovulation-induction (5.03 vs. 6.59). However, after ovulation-induction and oocyte retrieval this score rose to 6.66 among oocyte-donators, whereas it remained essentially unchanged among women providing their own oocytes (6.66). The mean anxiety score for oocyte-donating women also rose following this procedure, from 5.87 to 7.65. Depression scores for both groups remained similar, before and after the procedure. Results showed that at the beginning of the ARP donating women have the same conditions as own oocyte women regarding depression and anxiety but after the egg harvesting they would suffer more damages regarding hypochondriasis and anxiety aspects.     

Resistance training reduces pain indices and improves quality of life and body strength in women with migraine disorders

Sport Sciences for Health - The benefits of resistance training (RT) for migraineurs appears to be lacking although beneficial of aerobic training have been shown in previous studies. The aim of...     

Patterns of Family,School, and Community Promotive Factors and Health Disparities Among Youth: Implications for Prevention Science

Prevention Science - Increasing knowledge of factors that promote health among youth from diverse backgrounds is an important step towards addressing health disparities. Although many promotive...     

Corpus luteum with ovarian stromal edema is associated with pelvic pain and confusion for ovarian torsion

Abdominal Radiology - To distinguish the corpus luteum with adjacent ovarian stromal edema as an entity associated with pelvic pain, with confounding ultrasound features that may lead to...     

Multisulfonate hyperbranched polyglycerol functionalized graphene oxide as an efficient reusable catalyst for green synthesis of benzo[a]pyrano-[2,3-c]phenazines under solvent-free conditions

A novel acid catalyst was prepared based on growing hyperbranched polyglycerol (HPG) on the surface of graphene oxide. Then, the hydroxyl groups of HPG on graphene oxide were functionalized by sulfonate groups to form an acid catalyst. The catalyst displayed a good loading level of acidic groups on the surface because of coating graphene oxide with HPG. This new catalyst is demonstrated to be highly effective in the preparation of benzo[a]pyrano[2,3-c]phenazine dyes.

A novel acid catalyst was prepared based on growing hyperbranched polyglycerol (HPG) on the surface of graphene oxide. Then, the hydroxyl groups of HPG on graphene oxide were functionalized by sulfonate groups to form an acid catalyst.