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991.
William W. Darrow Ph.D. Harold W. Jaffe M.D. Pauline A. Thomas M.D. Harry W. Haverkos M.D. Martha F. Rogers M.D. Mary E. Guinan M.D. Ph.D. David M. Auerbach M.D. Thomas J. Spira M.D. James W. Curran M.D. M.P.H. 《Archives of sexual behavior》1986,15(1):79-88
Effects of sex of interviewer and place of interview on the responses of 57 AIDS patients and 145 other homosexual men were studied. Data on sensitive topics were collected by five male and three female medical officers at places convenient to respondents. Male physicians recorded fellatio more frequently, but female physicians recorded younger ages of initiating homosexual activities and more frequent use of certain recreational drugs. These differences apparently were due to different patterns of sexual contact and drug use in four cities. Patients with AIDS tended to be interviewed in hospitals and doctors' offices, other men tended to be interviewed in hotel rooms, and patients tended to be different from other men. After adjustments were made for confounding, sex of interviewer and place of interview seemed to have little influence on the answers obtained.Presented at the annual meeting of the International Academy of Sex Research, Harriman, New York, November 22, 1983. 相似文献
992.
Cheryl R Clark Ichiro Kawachi Louise Ryan Karen Ertel Martha E Fay Lisa F Berkman 《BMC public health》2009,9(1):162
Background
We investigated whether lack of perceived neighborhood safety due to crime, or living in high crime neighborhoods was associated with incident mobility disability in elderly populations. We hypothesized that low-income elders and elders at retirement age (65 – 74) would be at greatest risk of mobility disability onset in the face of perceived or measured crime-related safety hazards. 相似文献993.
T. Heather Herdman Marjory Gordon Martha Craft‐Rosenberg 《International journal of nursing knowledge》2000,11(4):176-178
This column describes the work of the Nursing Diagnosis Extension and Classification (NDEC) research team, which works in a collaborative agreement with NANDA to refine and extend the diagnosis classification. 相似文献
994.
GREGORY I. Bain 《ANZ journal of surgery》1999,69(8):578-581
This paper presents a review of common complex elbow traumatic disorders. It presents an algorithm to aid in the management of these cases and discusses indications for radial head replacement and dynamic external fixateurs. 相似文献
995.
Chronic recurrent volar dislocation of the distal radioulnar joint is a rare condition for which many operative procedures have been described. We describe a case of painful dislocation on supination. Investigation of the distal radioulnar joint revealed the absence of degenerative arthritis and a flat sigmoid notch that permitted dislocation. The case was successfully treated by osteoplasty of the volar lip of the sigmoid notch to create a buttress that prevented volar dislocation. 相似文献
996.
997.
998.
Frank Martiniuk Martha L Hale Andrew D Ellington Kam-Meng Tchou-Wong 《World journal of gastroenterology : WJG》2008,14(41):6360-6365
AIM: To investigate the therapeutic potential of an RNA ligand (aptamer) specific for the catalytic ricin A-chain (RTA), the protective effects of a 31-nucleo- tide RNA aptamer (31RA), which formed a high affinity complex with RTA, against ricin-induced toxicity in cell- based luciferase translation and cell cytotoxicity assays were evaluated. METHODS: To test the therapeutic potential of anti- RTA aptamers in Chinese hamster ovary (CliO) AA8 cells stably transfected with a tetracycline regulatable promoter, ricin ribotoxicity was measured us- ing luciferase and ricin-induced cytotoxicity was ascertained by MTS cell proliferation assay with tet- razolium compound [3-(4,5-dimethylthiazol-2-yl)- 5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H- tetrazolium]. RESULTS: Inhibition of protein synthesis by ricin in CliO AA8 cells resulted in diminished luciferase activity and treatment with polyclonal antibody against degly- cosylated RTA (dgA) neutralized the inhibitory effects of ricin on luciferase activity and protected against ricin-induced cytotoxicity as measured by MTS assay. The 31RA anti-RTA aptamer inhibited the translation of luciferase mRNA in cell-free reticulocyte translation assay. 31RA aptamer also partially neutralized the inhibitory effects of ricin on luciferase activity and partially protected against ricin-induced cytotoxicity in CliO AA8 cells. CONCLUSION: We have shown that anti-RTA RNA aptamer can protect against ricin ribotoxicity in cell- based luciferase and cell cytotoxicity assays. Hence, RNA aptamer that inhibits RTA enzymatic activity represents a novel class of nucleic acid inhibitor that has the potential to be developed as a therapeutic agent for the treatment of ricin intoxication. 相似文献
999.
Karen I. Kroeker Vincent G. Bain Thomas Shaw‐Stiffel Tse‐Ling Fong Eric M. Yoshida 《Liver international》2008,28(9):1250-1255
Goals: To assess the current practice patterns of liver transplant centres in Canada and the USA regarding transplant eligibility. Background: Liver transplantation is an evolving field and today remains the only life‐sustaining treatment for end‐stage liver disease. Issues of allocation and transplant eligibility are important factors in the ethical practice of medicine. Study: Questionnaires were mailed to liver transplant programme directors in Canada and the USA inquiring about current practices regarding recipient eligibility. Results: This study demonstrates that there is consensus in the use of other eligibility criteria, including non‐compliance, social status, abstinence from alcohol and methadone and cocaine use. Interestingly, literature is lacking to support the use of these parameters as eligibility criteria with the exception of alcohol. There is a lack in consensus regarding marijuana use, human immunodeficiency virus status, ability to accept blood transfusions and prisoner status. The literature suggests that liver transplantation in select patients who refuse blood transfusions results in good outcomes. Conclusions: Important decisions regarding transplant eligibility still have to be made empirically in the absence of scientific literature about various social issues. While consensus among transplant programmes is useful, it is important that we continue to use the evidence in the literature to revise these eligibility criteria, keeping in mind ethical principles applied to the access and allocation of a scarce resource. 相似文献
1000.
Zora Djuric Sherry M Lewis Ming H Lu Martha Mayhugh Lilian Naegeli Ning Tang Ronald W Hart 《Toxicological sciences》2002,66(1):125-130
Caloric restriction has previously been shown to decrease levels of oxidative stress in rats. In this study, we examined the effects of 5 different caloric intake levels on one type of oxidative DNA damage in rat mammary gland, blood, and liver. Animals were fed modified AIN-93G diets to accommodate 10, 20, 30, or 40% calorie restriction (CR), relative to ad libitum (AL) consumption. The intakes of fat, protein, vitamins, and minerals thus remained constant, but total carbohydrate intake decreased. Body weights of the animals at 20 weeks reflected the degree of restriction, but in the first 10 weeks, weight gain in the 10% CR group was not reduced relative to animals fed ad libitum. Levels of 5-hydroxymethyl-2'-deoxyuridine increased with time in mammary gland and nucleated blood cells regardless of CR level, indicating an effect of animal age, despite the fact that the animals were only 7 months old after the 20-week dietary study. In liver, however, there was a trend towards decreased DNA damage levels with time. The effect of diet on levels of 5-hydroxymethyl-2'-deoxyuridine was not statistically significant, indicating no protective effect of restricted dietary carbohydrate. This dietary study differed from previous work in that the modified AIN-93G dietary formulation contains relatively higher levels of fat and vitamins K, E, and B(12), and it has certain added trace minerals. This data raises the question of whether the previously reported effects of calorie restriction on preventing oxidative stress in mammary gland are dependent on the type of dietary formulation used. 相似文献