全文获取类型
收费全文 | 3172篇 |
免费 | 189篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 55篇 |
妇产科学 | 37篇 |
基础医学 | 492篇 |
口腔科学 | 95篇 |
临床医学 | 316篇 |
内科学 | 494篇 |
皮肤病学 | 48篇 |
神经病学 | 285篇 |
特种医学 | 146篇 |
外科学 | 558篇 |
综合类 | 21篇 |
一般理论 | 10篇 |
预防医学 | 270篇 |
眼科学 | 96篇 |
药学 | 229篇 |
中国医学 | 4篇 |
肿瘤学 | 190篇 |
出版年
2023年 | 20篇 |
2022年 | 76篇 |
2021年 | 130篇 |
2020年 | 55篇 |
2019年 | 71篇 |
2018年 | 80篇 |
2017年 | 90篇 |
2016年 | 96篇 |
2015年 | 98篇 |
2014年 | 153篇 |
2013年 | 174篇 |
2012年 | 242篇 |
2011年 | 252篇 |
2010年 | 149篇 |
2009年 | 128篇 |
2008年 | 216篇 |
2007年 | 216篇 |
2006年 | 179篇 |
2005年 | 164篇 |
2004年 | 159篇 |
2003年 | 153篇 |
2002年 | 127篇 |
2001年 | 35篇 |
2000年 | 18篇 |
1999年 | 19篇 |
1998年 | 19篇 |
1997年 | 16篇 |
1996年 | 13篇 |
1995年 | 6篇 |
1992年 | 9篇 |
1991年 | 7篇 |
1990年 | 11篇 |
1989年 | 13篇 |
1988年 | 18篇 |
1987年 | 9篇 |
1986年 | 14篇 |
1985年 | 9篇 |
1984年 | 9篇 |
1983年 | 10篇 |
1977年 | 5篇 |
1974年 | 6篇 |
1970年 | 10篇 |
1969年 | 5篇 |
1966年 | 5篇 |
1965年 | 5篇 |
1960年 | 5篇 |
1959年 | 5篇 |
1957年 | 5篇 |
1955年 | 5篇 |
1954年 | 7篇 |
排序方式: 共有3386条查询结果,搜索用时 15 毫秒
31.
Anne Mannila Jarkko Rautio Marko Lehtonen Tomi J?rvinen Jouko Savolainen 《European journal of pharmaceutical sciences》2005,24(1):101-105
Chronic use of non-steroidal anti-inflammatory drugs may reduce the risk or delay the onset of Alzheimer's disease. To date, only limited information exists on the brain distribution of these drugs. The objective of this study was to determine the absolute brain delivery of ibuprofen by using constant in vivo infusion in rats. Ibuprofen was infused to steady-state concentrations both in plasma and brain tissue. Ibuprofen levels in plasma and brain tissue were measured by RP-HPLC after the plasma and the brain samples were purified by protein precipitation and solid phase extraction, respectively. Results indicate that both plasma and brain concentrations reached steady-state within 6h, and that the brain to plasma ratio of ibuprofen was only 0.02. Thus, limited brain penetration prevents the possible use of ibuprofen in treating or preventing neurodegenerative disorders such as Alzheimer's disease. 相似文献
32.
33.
Stephen Sameroff Rafal Tokarz Marko Vucelja Komal Jain Alexandra Oleynik Marko Boljfeti Linda Bjedov Rachel A. Yates Josip Margaleti Christopher A. L. Oura Walter Ian Lipkin Lidija Cvetko Krajinovi Alemka Markoti 《Viruses》2022,14(5)
Tick-borne diseases are a serious threat to both public and veterinary health. In this study, we used high-throughput sequencing to characterize the virome of three tick species implicated in the spread of vector-borne disease throughout Croatia. Ten viruses were identified, including seven potential novel species within the viral families Flaviviridae, Nyamiviridae, Rhabdoviridae, Peribunyaviridae, Phenuiviridae, and Nairoviridae. 相似文献
34.
35.
Janke Greidanus Pax H. B. Willemse Donald R. A. Uges Evrard T. H. G. J. Oremus Zacharias J. Langen Elisabeth G. E. Vries 《Pharmacy World & Science》1988,10(6):237-245
With the recent development of reliable portable pumps and safe venous access systems, continuous infusion of chemotherapeutic agents on an out-patient basis has become feasible. Advantages of continuous infusion are the long-term exposure of tumour cells to the drug and the fact that most toxic effects are reduced for doxorubicin, epirubicin and mitoxantrone due to elimination of the high peak plasma levels. Preliminary data for doxorubicin suggest that its antitumour activity is maintained. Pharmacokinetic studies with epirubicin and mitoxantrone showed a linear relationship between drug dose infused and the steady-state plasma level for these drugs. The area under the curve for leukocytes drug level was higher during continuous infusion than after an equitoxic bolus injection of epirubicin and mitoxantrone. Well-randomized clinical trials will be necessary to investigate the role of continuous infusion of antracyclines and mitoxantrone in cancer chemotherapy in the future. 相似文献
36.
BACKGROUND: Lichen sclerosus (LS) is a chronic inflammatory skin condition, which most commonly causes dysuria, pruritus and soreness of the vulval and perianal areas. Potent topical corticosteroids are used for the treatment of LS, but it is well known that they inhibit collagen synthesis and cause skin atrophy as a side effect. METHODS: The present pilot study evaluated the efficacy and safety of pimecrolimus cream 1% applied twice daily for up to 6 months in 29 women with severe LS. RESULTS: Of the 26 subjects who completed the follow-up period, 42% (11/26) were in complete remission with relief from itchiness, pain and inflammation. A 3.5-fold increase in type I collagen synthesis and a 7.5-fold increase in type III collagen synthesis of the affected areas was detected after 2 months of pimecrolimus treatment. There were no systemic adverse reactions, although mild local skin reactions were reported by 50% of the patients. Blood concentrations of pimecrolimus were checked in 10/26 patients (39%) and were undetectable in all cases. CONCLUSIONS: Patient-applied 1% pimecrolimus cream is safe and effective for the treatment of LS. 相似文献
37.
38.
A gas-liquid chromatographic method is described for the determination of the local anaesthetics carbisocaine, heptacaine and pentacaine in plasma. A C(18) solid-phase extraction was used in a modification to increase selectivity. Following on-column derivatization with trimethylanilinium hydroxide, the analytes were determined by means of capillary gas chromatography and nitrogen-phosphorus selective detection. In comparison with flame ionization detection, the sensitivity of NPD was 20 times higher with a limit of determination in plasma of 10 ng ml(-1). 相似文献
39.
Michal Marko Petr Hrubý Martin Jan
a Jakub Kíkala Jan Hajzler Frantiek oukal Jan Vojtíek Martin Doleal 《Materials》2022,15(14)
The possibility of the formation of an alkali–silicate reaction (ASR) is a crucial issue for the service life of concrete. The coexistence of key parameters such as the presence of alkalis, reactive SiO2, humidity, and temperature predetermine the possibility of its formation and application. When an ASR gel forms, it results in the concreting cracking and spalling as well as in the deterioration of its overall properties. The risk of ASR depends on the concentration of alkalis and their mobility, which influence their ability to penetrate the concrete. The objective of this study was to determine the ionic mobility of not only Na+ and K+, but Ca2+ as well, from external sources (0.5 and 1.0 mol/L solutions of Na/K carbonate, nitrate, and hydroxide) to a cementitious matrix as the precursor for ASR. The concentrations of ions in both the immersion solutions (ICP) and the cementitious matrix itself (SEM-EDX) were studied as a function of time, from 0 to 120 days, for leaching, and according to temperature (25 and 40 °C). The reaction products were characterized using SEM-EDX. Different diffusion rates and behavior were observed depending on the anion type of the external alkali source. Both sodium and potassium ions in all the three environments studied, namely carbonate, hydroxide, and nitrate, penetrated into the composite and further into its structure by different mechanisms. The action of hydroxides, in particular, transformed the original hydration products into calcium-silicate-hydrate (CASH) or ASR gel, while nitrates crystallized in pores and did not cause any changes in the hydration product. The driving force was the increased temperature of the experiment as well as the increased concentration of the solution to which the test specimen was exposed. 相似文献
40.
Jelle Koopsen Catharina E. van Ewijk Roisin Bavalia Akke Cornelissen Sylvia M. Bruisten Floor de Gee Alvin X. Han Maarten de Jong Menno D. de Jong Marcel Jonges Norin Khawaja Fleur M.H.P.A. Koene Mariken van der Lubben Iris Mikulic Sjoerd P.H. Rebers Colin A. Russell Janke Schinkel Anja J.M. Schreijer Judith A. den Uil Matthijs R.A. Welkers Tjalling Leenstra 《Emerging infectious diseases》2022,28(5):1012
We report a severe acute respiratory syndrome coronavirus 2 superspreading event in the Netherlands after distancing rules were lifted in nightclubs, despite requiring a negative test or vaccination. This occurrence illustrates the potential for rapid dissemination of variants in largely unvaccinated populations under such conditions. We detected subsequent community transmission of this strain. 相似文献