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71.
Pia Pajunen Mikko Syvänne Graciela Castro Markku S. Nieminen Marja-Riitta Taskinen 《Scandinavian cardiovascular journal : SCJ》2013,47(2):96-100
Objective - To investigate the relation between severity and extent of coronary artery disease (CAD) and in vitro cholesterol efflux capacity. Design - This study consisted of 46 type 2 diabetic, and 42 nondiabetic men undergoing coronary angiography. Quantitative coronary angiography was used to estimate the severity, extent, and overall "atheroma burden" of CAD. The capacity of patient plasma to induce cholesterol efflux from cultured Fu5AH rat hepatoma cells was measured in vitro. Results - In the combined study population (n = 88), there was a significant inverse correlation between efflux and global atheroma burden (r = -0.23, p < 0.05). In the diabetic group, the global atheroma burden index was independently associated both with cholesterol efflux and with LpA-I levels. However, in the nondiabetic CAD group this association was lost when efflux and LpA-I levels were included in the same model. Conclusion - The present study demonstrated that efflux capacity was inversely associated with the severity and extent of CAD. In the diabetic group this association was independent of LpA-I levels, suggesting impaired antiatherogenic potential of these particles in type 2 diabetic patients. 相似文献
72.
Mäki M Aine L 《Journal of the American Dental Association (1939)》2012,143(7):730; author reply 730, 732
73.
Hanna Putkonen Matti Holi Riittakerttu Kaltiala-Heino Jyrki Korkeila Markku Eronen 《Nordic journal of psychiatry》2013,67(2):148-151
This study examined Finnish psychiatric trainees’ views on their education. This was a survey study of nationwide data on Finnish psychiatric trainees in 2001. The quality of training was considered at least moderate by 84% of the respondents. Training on epidemiology, on taking history and status, and on psychopharmacology was considered the best. Quality was rated bad for training in leadership and administration, and educating the community. Research was done by 20%, and a personal clinical supervisor was appointed to 52% of the respondents. Offensive treatment had been experienced by 49% of the trainees in this study. Generally, studies of training also reflect strengths and weaknesses of the profession. Based on our results, it seems especially that training in leadership and in educating the community need to be improved; both of these are quintessential skills to survive in the struggle for economic and human resources. Furthermore, treatment of the trainees could still be better; attention should be paid to supervision of all trainees. Moreover, research must become more attractive. Psychiatry can be developed by the development of psychiatric training. 相似文献
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OBJECTIVE: The purpose of this study was to develop and test a data-mining system for the online determination of mean DS, M, and FS or DMFS values per subject at different ages from electronic patient records at two health centers to see if there are north-south differences in oral health in Finland. MATERIAL AND METHODS: The mean index values were determined at two health centers using the codes of dental charts and progress notes of electronic dental records during the digital era of more than 10 years in a total of 153,619 subjects of all ages. Extracted teeth, as well as sound, carious, and restored tooth surfaces, were recorded from the dental charts. Treatments were then additionally registered from progress notes of the records when performed. RESULTS: The cumulative DS and FS values were similar in subjects under the age of 20 years at both health centers. In adults, caries was more abundant in northern Finland, where there was a higher number of restored surfaces (>40) registered, compared to only 30 in southern Finland at the age of 40 years. A high increase in the number of extractions began at age 45 in the north compared to age 70 in the south. These changes were clearly reflected in the DMFS index. CONCLUSIONS: Online determination of health parameters is a feasible methodology. The results revealed that north-south regional differences in dental health still occur in adults in Finland, but not in subjects younger than 20 years of age. 相似文献
76.
Timo Rantalainen Rachel L. Duckham Harri Suominen Ari Heinonen Markku Alén Marko T. Korhonen 《Calcified tissue international》2014,95(2):132-140
High impact loading is known to prevent some of the age-related bone loss but its effects on the density distribution of cortical bone are relatively unknown. This study examined the effects of age and habitual sprinting on tibial and fibular mid-shaft bone traits (structural, cortical radial and polar bone mineral density distributions). Data from 67 habitual male sprinters aged 19–39 and 65–84 years, and 60 non-athletic men (referents) aged 21–39 and 65–80 years are reported. Tibial and fibular mid-shaft bone traits (strength strain index SSI, cortical density CoD, and polar and radial cortical density distributions) were assessed with peripheral quantitative computed tomography. Analysis of covariance (ANCOVA) adjusted for height and body mass indicated that the sprinters had 21 % greater tibial SSI (P < 0.001) compared to the referents, with no group × age-group interaction (P = 0.54). At the fibula no group difference or group × age-group interaction was identified (P = 0.12–0.81). For tibial radial density distribution ANCOVA indicated no group × radial division (P = 0.50) or group × age-group × division interaction (P = 0.63), whereas an age × radial division interaction was observed (P < 0.001). For polar density distribution, no age-group × polar sector (P = 0.21), group × polar sector (P = 0.46), or group × age-group × polar sector interactions were detected (P = 0.15). Habitual sprint training appears to maintain tibial bone strength, but not radial cortical density distribution into older age. Fibular bone strength appeared unaffected by habitual sprinting. 相似文献
77.
Fiona Sewell Kathryn Chapman Paul Baldrick David Brewster Alan Broadmeadow Paul Brown Leigh Ann Burns-Naas Janet Clarke Alex Constan Jessica Couch Oliver Czupalla Andy Danks Joseph DeGeorge Lolke de Haan Klaudia Hettinger Marilyn Hill Matthias Festag Abby Jacobs David Jacobson-Kram Stephan Kopytek Helga Lorenz Sophia Gry Moesgaard Emma Moore Markku Pasanen Rick Perry Ian Ragan Sally Robinson Petra M. Schmitt Brian Short Beatriz Silva Lima Diane Smith Sue Sparrow Yvette van Bekkum David Jones 《Regulatory toxicology and pharmacology : RTP》2014
78.
Jani Rankinen Petri Haataja LeoPekka Lyytikinen Heini Huhtala Terho Lehtimki Mika Khnen Markku Eskola Andrs Ricardo PrezRiera Antti Jula Harri Rissanen Kjell Nikus Jussi Hernesniemi 《Annals of noninvasive electrocardiology》2021,26(1)
BackgroundPrevious population studies have presented conflicting results regarding the prognostic impact of intraventricular conduction delays (IVCD).MethodsWe studied long‐term prognostic impact and the association with comorbidities of eight IVCDs in a random sample of 6,299 Finnish subjects (2,857 men and 3,442 women, mean age 52.8, SD 14.9 years) aged 30 or over who participated in the health examination including 12‐lead ECG. For left bundle branch block (LBBB) and non‐specific IVCD (NSIVCD), two different definitions were used.ResultsDuring 16.5 years’ follow‐up, 1,309 of the 6,299 subjects (20.8%) died and of these 655 (10.4%) were cardiovascular (CV) deaths. After controlling for known clinical risk factors, the hazard ratio for CV death, compared with individuals without IVCD, was 1.55 for the Minnesota definition of LBBB (95% confidence interval 1.04–2.31, p = .032) and 1.27 (95% confidence interval 0.80–2.02, p = .308) for the Strauss’ definition of LBBB. Subjects with NSIVCD were associated with twofold to threefold increase in CV mortality depending on the definition. While right bundle branch block, left anterior fascicular block and incomplete bundle branch blocks were associated with seemingly higher mortality, this was no longer the case after adjustment for age and sex. The presence of R‐R’ pattern was not associated with any adverse outcome.ConclusionsIn a population study with long‐term follow‐up, NSIVCD and Minnesota definition of LBBB were independently associated with CV mortality. Other IVCDs had no significant impact on prognosis. The prognostic impact of LBBB and NSIVCD was affected by the definition of the conduction disorder. 相似文献
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