首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3819985篇
  免费   314272篇
  国内免费   14761篇
耳鼻咽喉   51234篇
儿科学   120763篇
妇产科学   98657篇
基础医学   596962篇
口腔科学   103116篇
临床医学   345968篇
内科学   683236篇
皮肤病学   99155篇
神经病学   321973篇
特种医学   148689篇
外国民族医学   265篇
外科学   588846篇
综合类   114550篇
现状与发展   23篇
一般理论   2450篇
预防医学   315861篇
眼科学   90086篇
药学   264554篇
  26篇
中国医学   11469篇
肿瘤学   191135篇
  2021年   56028篇
  2020年   35698篇
  2019年   58924篇
  2018年   73475篇
  2017年   56076篇
  2016年   61992篇
  2015年   75688篇
  2014年   110022篇
  2013年   175765篇
  2012年   109504篇
  2011年   111897篇
  2010年   122507篇
  2009年   124941篇
  2008年   97943篇
  2007年   103026篇
  2006年   112255篇
  2005年   106637篇
  2004年   108383篇
  2003年   97816篇
  2002年   86976篇
  2001年   136304篇
  2000年   129782篇
  1999年   122192篇
  1998年   68805篇
  1997年   65413篇
  1996年   63111篇
  1995年   58648篇
  1994年   52618篇
  1993年   48973篇
  1992年   85130篇
  1991年   81047篇
  1990年   76727篇
  1989年   75178篇
  1988年   69082篇
  1987年   67275篇
  1986年   63590篇
  1985年   62842篇
  1984年   54922篇
  1983年   49618篇
  1982年   43667篇
  1981年   41022篇
  1980年   38486篇
  1979年   44873篇
  1978年   38258篇
  1977年   34938篇
  1976年   31975篇
  1975年   30796篇
  1974年   32495篇
  1973年   31208篇
  1972年   29050篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
102.
MicroRNAs (miRNAs) play important roles in prostate cancer development. However, it remains unclear how individual miRNAs contribute to the initiation and progression of prostate cancer. Here we show that a basal layer‐enriched miRNA is required for prostate tumorigenesis. We identify miR‐205 as the most highly expressed miRNA and enriched in the basal cells of the prostate. Although miR‐205 is not required for normal prostate development and homeostasis, genetic deletion of miR‐205 in a Pten null tumor model significantly compromises tumor progression and does not promote metastasis. In Pten null basal cells, loss of miR‐205 attenuates pAkt levels and promotes cellular senescence. Furthermore, although overexpression of miR‐205 in prostate cancer cells with luminal phenotypes inhibits cell growth in both human and mouse, miR‐205 has a minimal effect on the growth of a normal human prostate cell line. Taken together, we have provided genetic evidence for a requirement of miR‐205 in the progression of Pten null‐induced prostate cancer.  相似文献   
103.
104.
105.
Secondary tricuspid regurgitation (TR) caused by right ventricular enlargement in the setting of left heart disease/pulmonary hypertension has been well described. In contrast, that associated with right atrial enlargement—atrial functional TR (AF‐TR)—remains largely underappreciated. AF‐TR most often occurs in the setting of lone atrial fibrillation, although it is also seen in its absence (idiopathic AF‐TR). Several recent studies have found that the prevalence, hemodynamic significance, and prognosis of AF‐TR are not inconsequential, suggesting increased physician awareness of this novel clinical entity is warranted. This article discusses the pathogenesis, echocardiographic findings, and treatment of this underappreciated cause of secondary TR.  相似文献   
106.
We review the spectrum of cutaneous disorders associated with inflammatory and neoplastic plasmacytic pathology. Because plasma cells are derived from B‐lymphocytes our overview includes discussion of certain lymphoplasmacytic proliferations. It is structured along histopathological lines, addressing conditions characterized by (a) cutaneous plasma cell infiltrates, (b) deposits of plasma cell products or their derivatives in the skin and (c) miscellaneous, poorly understood cutaneous complications of plasmacytic disorders. Lesions arising primarily in the skin and those due to cutaneous involvement by multisystem disorders are addressed. The range includes a spectrum of tumefactive and circulatory manifestations. We highlight key clinical and pathological features of the different conditions and outline recent advances in our understanding of these entities. By emphasizing the dermatopathological characteristics of this spectrum of disorders we hope to hone the diagnostic accuracy of practitioners in the field.  相似文献   
107.
108.
BackgroundThe aim of this study was to estimate the prevalence of dental prosthetic treatment and to investigate the demographic, social, economic and medical factors associated with the use of fixed and removable dentures in a representative sample of adults living in France.MethodsThe data were obtained from the 2002–2003 Decennial Health Survey, a cross-sectional study of a representative sample of the population living in France, which included 29,679 adults. Information was collected by interview. The variables collected were fixed denture, removable denture, age, gender, number of children, area of residence, nationality, educational attainment, family social status, employment status, annual household income per capita, supplementary insurance, chronic disease, eyesight problems/glasses, hearing problems/hearing aids. Multinomial logistic regression models were used to study the relationship between prosthetic treatment and demographic, socioeconomic and medical characteristics unadjusted, adjusted for age and adjusted for all the characteristics.ResultsThe prevalence of prosthetic treatment was 34.6% (95% confidence interval (CI): [34.1; 35.2]) for fixed prosthetic dentures and 13.8% (95% CI: [13.4; 14.2]) for removable prosthetic dentures. We showed a gradient between educational attainment and removable dentures; the odds ratio adjusted for all the variables (aOR) associated with no or primary education compared to post-secondary education was 2.56; 95% CI: [2.09; 3.13]. When annual household income per capita was low, subjects were less likely to report fixed dentures (aOR = 0.68; 95% CI: [0.62; 0.75]) than those with high annual household income per capita. Individuals without insurance less often reported fixed dentures than those with private insurance. Those reporting chronic disease were less likely to report fixed dentures (aOR = 0.87; 95% CI: [0.79; 0.95]) but more likely to report removable dentures (aOR = 1.29; 95% CI: [1.17; 1.43]) than those without chronic disease.ConclusionThis study reveals social, economic and medical inequalities in fixed and removable prosthetic treatment among adults in France.  相似文献   
109.
110.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号