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81.
Repair of erosions in rheumatoid arthritis does occur. Results from 2 studies by the OMERACT Subcommittee on Healing of Erosions 总被引:4,自引:0,他引:4
Sharp JT Van Der Heijde D Boers M Boonen A Bruynesteyn K Emery P Genant HK Herborn G Jurik A Lassere M McQueen F Østergaard M Peterfy C Rau R Strand V Wassenberg S Weissman B;Subcommittee on Healing of Erosions of the OMERACT Imaging Committee 《The Journal of rheumatology》2003,30(5):1102-1107
The committee was charged with determining whether healing of erosions in rheumatoid arthritis (RA) occurs. Two exercises were performed: The first asked the committee members, as a panel of experts, to express agreement or disagreement with the presence of improvement and features of bone reaction to injury in images submitted by members as examples of healing. The second presented panel members with 28 pairs of serial images, 14 chosen to illustrate progression and 14 chosen to illustrate repair. Agreement was tested on 8 items: global judgment on which image in the pair was better, relative size of the erosion in the 2 images, judgment on which image was first, presence and extent of sclerosis, cortication, filling-in, remodeling, and reconstituting normal structure. Our results showed good agreement, among the 15 respondents, on global assessment of which image was better and which image showed the smaller erosion. Correct assignment of sequence was only slightly better than expected by chance (in 65% of the cases). Agreement was poor regarding the presence of morphologic features of bone repair. A majority of a panel of experts agreed on which 2nd images in a set of paired, serial images represented improvement and which showed progression based on global assessment of which was better and on size of erosion. Features of bone repair were not distinctive and did not enable the panel to deduce the correct sequence of the serial images. This study provides evidence that repair of bone damage in RA does occur, resulting in some degree of improvement, which was recognized by a majority of a panel of experts. 相似文献
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Aspects of control and substance use among middle‐aged and older adults with bipolar disorder
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Marissa N. Stalman BSN Sarah L. Canham PhD Atiya Mahmood PhD David King PhD Norm O'Rourke PhD RPsych 《International journal of mental health nursing》2018,27(2):833-840
High prevalence rates of alcohol and substance use disorders have been reported among persons with bipolar disorder (BD). In the present study, we explored the daily experiences of middle‐aged and older adults living with BD who reported regular substance use and the ways in which participants expressed ‘control’ in relation to their use of alcohol and other substances. Semistructured, in‐depth interviews were conducted with 12 participants (nine women and three men), aged 36–57 years of age (mean = 49 years). Thematic analyses identified emergent themes and patterns in participants’ life histories. The theme of ‘control’ emerged as central to participants’ reports, and was organized into four categories: (i) substance use to control BD symptoms; (ii) substance use provides a sense of being in control; (iii) methods of controlled substance use; and (iv) not having control: overreliance on substances. Implications of the present study include the need for nurses to openly discuss the use of alcohol and other drugs with persons with BD, provide health information and screening, and determine whether persons with BD feel they have control over their substance use. Several lines of research with persons who have BD and use substances are suggested. 相似文献
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Purpose of Review
Pituitary tumors account for approximately 17% of all intracranial neoplasms, with the majority being pituitary adenomas. Often, these are found incidentally during a workup for headache; however, the relationship between symptom and pathology remains unclear. The purpose of this article is to review the most recent literature on the epidemiology, pathophysiology, and management of headaches in patients with pituitary tumors.Recent Findings
The current literature is limited, with few prospective trials focusing on this question. With the exception of pituitary apoplexy, the relationship between headaches and pituitary masses remains unclear. Intervention does not always improve headache and can lead to development of new headache syndromes.Summary
Further research is needed to better elucidate the relationship between pituitary tumors and headaches. Headache alone is rarely an indication for surgical management of a pituitary adenoma.86.
Experimental paradigms used in affective and clinical science often use stimuli such as images, scenarios, videos, or words to elicit emotional responses in study participants. Choosing appropriate stimuli that are highly evocative is essential to the study of emotional processes in both healthy and clinical populations. Selecting one set of stimuli that will be relevant for all subjects can be challenging because not every person responds the same way to a given stimulus. Machine learning can facilitate the personalization of such stimuli. The current study applied a novel statistical approach called a recommender algorithm to the selection of highly threatening words for a trauma-exposed population (N?=?837). Participants rated 513 threatening words, and we trained a user–user collaborative filtering recommender algorithm. The algorithm uses similarities between individuals to predict ratings for unrated words. We compared threat ratings for algorithm-based word selection to a random word set, a word set previously used in research, and trauma-specific word sets. Algorithm-selected personalized words were more threatening compared to non-personalized words with large effects (ds?=?2.10–2.92). Recommender algorithms can automate the personalization of stimuli from a large pool of possible stimuli to maximize emotional reactivity in research paradigms. These methods also hold potential for the personalization of behavioral treatments administered remotely where a provider is not available to tailor an intervention to the individual. The word personalization algorithm is available for use online (https://threat-word-predictor.herokuapp.com/). 相似文献
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Reed Elizabeth West Brooke S. Frost Elizabeth Salazar Marissa Silverman Jay G. McIntosh Craig T. Gómez María Gudelia Rangel Urada Lianne A. Brouwer Kimberly C. 《AIDS and behavior》2022,26(10):3210-3219
AIDS and Behavior - Economic vulnerability is often reported to underlie involvement in sex work among female sex workers (FSW), but may also create urgency in women’s work, limiting... 相似文献
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Ko DT Donovan LR Huynh T Rinfret S So DY Love MP Galbraith D Tu JV;Canadian Cardiovascular Outcomes Research Team 《The Canadian journal of cardiology》2008,24(11):839-843