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排序方式: 共有1011条查询结果,搜索用时 15 毫秒
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Soumeya Abed Alisa Tubsuwan Porntip Chaichompoo In Hyun Park Alice Pailleret A?ssa Benyoucef Lucie Tosca Edouard De Dreuzy Anais Paulard Marine Granger-Locatelli Francis Relouzat Stéphane Prost Gerard Tachdjian Suthat Fucharoen George Q. Daley Emmanuel Payen Stany Chrétien Philippe Leboulch Le?la Maouche-Chrétien 《Haematologica》2015,100(10):e428-e431
95.
Maximilien Barret Marine Camus Sarah Leblanc Romain Coriat Frédéric Prat Stanislas Chaussade 《World journal of gastrointestinal endoscopy》2015,7(8):830-832
Indigocarmine chromoendoscopy has been proven to improve the detection of colonic lesions during screening colonoscopy, and is associated with increased adenoma detection rates. Furthermore, it is commonly used to help in the delineation and characterization of colorectal neoplasms. However, it usually requires the use of a spraying catheter that decreases the suction capacity of the endoscope, and is time- consuming. Herein, we report on the feasibility of indigo carmine chromoendoscopy during colonoscopy without using a spraying catheter, with the dye being administered through the air/water channel of the endoscope. Since the suction channel remains free, the air can be exsufflated and the staining then applies uniformly onto the colonic walls with the excess indigocarmine dye being immediately eliminated. In our experience with various types of colonoscopes and cap-assisted colonoscopy, this procedure makes indigocarmine chromoendoscopy much easier and quicker to perform, and might save the use of a spray catheter. 相似文献
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Samuel Sarrazin Marc-Antoine d’Albis Colm McDonald Julia Linke Michèle Wessa Mary Phillips Marine Delavest Louise Emsell Amelia Versace Jorge Almeida Jean-Fran?ois Mangin Cyril Poupon Katia Le Dudal Claire Daban Nora Hamdani Marion Leboyer Josselin Houenou 《Journal of psychiatry & neuroscience : JPN》2015,40(5):352-359
Background
Previous studies have reported MRI abnormalities of the corpus callosum (CC) in patients with bipolar disorder (BD), although only a few studies have directly compared callosal areas in psychotic versus nonpsychotic patients with this disorder. We sought to compare regional callosal areas in a large international multicentre sample of patients with BD and healthy controls.Methods
We analyzed anatomic T1 MRI data of patients with BD-I and healthy controls recruited from 4 sites (France, Germany, Ireland and the United States). We obtained the mid-sagittal areas of 7 CC subregions using an automatic CC delineation. Differences in regional callosal areas between patients and controls were compared using linear mixed models (adjusting for age, sex, handedness, brain volume, history of alcohol abuse/dependence, lithium or antipsychotic medication status, symptomatic status and site) and multiple comparisons correction. We also compared regional areas of the CC between patients with BD with and without a history of psychotic features.Results
We included 172 patients and 146 controls in our study. Patients with BD had smaller adjusted mid-sagittal CC areas than controls along the posterior body, the isthmus and the splenium of the CC. Patients with a positive history of psychotic features had greater adjusted area of the rostral CC region than those without a history of psychotic features.Limitations
We found small to medium effect sizes, and there was no calibration technique among the sites.Conclusion
Our results suggest that BD with psychosis is associated with a different pattern of interhemispheric connectivity than BD without psychosis and could be considered a relevant neuroimaging subtype of BD. 相似文献98.
Zahra Kadri Carine Lefevre Olivier Goupille Tipparat Penglong Marine Granger-Locatelli Suthat Fucharoen Leila Maouche-Chretien Philippe Leboulch Stany Chretien 《Genes & development》2015,29(24):2603-2616
Tight coordination of cell proliferation and differentiation is central to red blood cell formation. Erythropoietin controls the proliferation and survival of red blood cell precursors, while variations in GATA-1/FOG-1 complex composition and concentrations drive their maturation. However, clear evidence of cross-talk between molecular pathways is lacking. Here, we show that erythropoietin activates AKT, which phosphorylates GATA-1 at Ser310, thereby increasing GATA-1 affinity for FOG-1. In turn, FOG-1 displaces pRb/E2F-2 from GATA-1, ultimately releasing free, proproliferative E2F-2. Mice bearing a Gata-1S310A mutation suffer from fatal anemia when a compensatory pathway for E2F-2 production involving insulin-like growth factor-1 (IGF-1) signaling is simultaneously abolished. In the context of the GATA-1V205G mutation resulting in lethal anemia, we show that the Ser310 cannot be phosphorylated and that constitutive phosphorylation at this position restores partial erythroid differentiation. This study sheds light on the GATA-1 pathways that synchronize cell proliferation and differentiation for tissue homeostasis. 相似文献
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Anne Isvy Marine Meunier Camille Gobeaux-Chenevier Emilie Maury Julien Wipff Chantal Job-Deslandre André Kahan Yannick Allanore 《Joint, bone, spine : revue du rhumatisme》2012,79(4):365-369
ObjectiveRituximab seems well tolerated in patients with rheumatoid arthritis (RA). However, variations in the gammaglobulin profile that might increase the infection risk have been reported. Here, our objective was to evaluate gammaglobulin concentrations and the infection risk in patients receiving rituximab therapy for RA in everyday practice.MethodsProspective single-center observational study of 65 patients with refractory RA (median age, 59 years; range, 26–83) treated with rituximab 1 g twice 15 days apart, with or without a further 1-g dose at least 6 months later depending on the clinical response. Gammaglobulins were assayed before each rituximab dose.ResultsThe median cumulative rituximab dose was 4 g (1–16) and the median time to retreatment was 8 months (6–16). Rituximab therapy significantly improved the DAS-28 score. The gammaglobulin concentration decreased significantly between the first and last rituximab dose (from 11.6 g/L [5–26] to 8.2 g/L [3–20], a ?2.6 g/L difference; P < 0.05). The decrease was larger in the 24 patients with cumulative rituximab doses greater than 5 g than in the 41 other patients (difference of ?4 vs ?2.7 g/L; P < 0.05). Three patients experienced severe infections, two in the high-dose group and one in the other group (P = 0.5).ConclusionThese data obtained in everyday practice constitute further evidence that rituximab is well-tolerated in patients with RA. Rituximab therapy was associated with a decrease in gammaglobulin concentrations that was greater in patients receiving higher cumulative doses. 相似文献