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71.
Niessner A Graf S Nikfardjam M Lehr S Maurer G Wojta J Huber K 《Thrombosis and haemostasis》2005,93(2):257-260
Components of the adaptive immune system, in particular lymphocytes and immunoglobulin, play a major role in advanced atherosclerotic lesions. We sought to determine whether routine, measurements of the relative number of circulating lymphocytes (%L) and gamma-globulin (%G) reflecting immunoglobulin are related to event-free survival in patients with stable coronary artery disease (CAD). We prospectively studied the combined endpoint all-cause mortality, myocardial infarction and coronary revascularization procedures in 141 patients after successful percutaneous coronary intervention during a median follow-up time of 13.2 years. Using Cox regression, we found a significant influence of %L on event-free survival (P=0.007) with a relative risk of 2.21 comparing third to first tertile. Subjects with higher %G values likewise had a shorter event-free survival (P=0.008) with a relative risk of 1.67 comparing third to first tertile. The predictive value of %L and %G remained significant after adjustment for demographic data, cardiovascular risk factors, extent of CAD and other inflammatory markers. We conclude that the fraction of gamma-globulin and in particular the relative lymphocyte cell count may serve as readily available and reliable prognostic tools for the long-term outcome in patients with stable CAD. 相似文献
72.
Aneurysms of the middle meningeal artery are rare, with no documented association with neurofibromatosis type 2 (NF2). Middle meningeal artery aneurysm embolization with N-butylcyanoacrylate has not been described, and altogether, few accounts exist regarding the endovascular management of these unusual aneurysms. In this case report of a patient with NF2, an unruptured middle meningeal artery aneurysm was prophylactically embolized in a previously unreported fashion by using N-butylcyanoacrylate acrylic glue. 相似文献
73.
Imidacloprid is an insecticide which has the nicotinic acetylcholine receptors (nAChRs) as its primary site of action; acetylcholine is the major excitatory neurotransmitter in the insect central nervous system (CNS). In this study, the action of imidacloprid was tested using the synapses of the respiratory central pattern generator of the beetle Tenebrio molitor. The no observed effect concentration (NOEC) for imidacloprid was estimated to be between 0.001 and 0.010 microM. A concentration of 0.10 microM caused hyperexcitation in firing of the respiratory motoneurons, while the concentration of 1.00 microM caused an abrupt increase in their frequency and then a complete inhibition of the activity of the respiratory motoneurons. The possible implication of the action of such low concentrations of imidacloprid in the contraction of the respiratory muscles is also demonstrated and discussed. 相似文献
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Cohen M Gereboff J 《The journal of the American Academy of Psychoanalysis and Dynamic Psychiatry》2004,32(2):267-286
The authors examine the conflicted relationship between Orthodox Judaism and psychoanalysis. Orthodox Jewish thinkers about psychology have responded to psychoanalysis as incompatible with the practice of Orthodox Judaism. On the other hand, those psychoanalytic writers who have examined the beliefs and practices of Orthodox Jews have tended to treat these issues in a reductionistic fashion. However, the authors find possibilities for reconciliation and dialogue in the work of Aaron Rabinowitz and Moshe Halevi Spero. 相似文献
76.
Schillinger M Domanovits H Paulis M Nikfardjam M Meron G Kurkciyan I Laggner AN 《Wiener klinische Wochenschrift》2002,114(21-22):917-922
BACKGROUND: Pulmonary congestion is associated with poor outcome in patients with acute coronary syndromes. In consecutive patients presenting with acute unexplained chest pain to a primary care facility, the prognostic impact of pulmonary congestion is indeterminate. Therefore, we assessed the predictive value of clinical signs of pulmonary congestion in patients presenting with acute chest pain to an emergency department with regard to the origin of the symptoms. METHODS: 1288 consecutive patients with acute chest pain were prospectively assessed for clinical signs of pulmonary congestion. The diagnosis was confirmed by chest radiography. The association of pulmonary congestion and short- and intermediate-term mortality in patients with coronary (n = 381) and non-coronary (n = 907) causes of chest pain was determined using multivariate Cox regression analysis. RESULTS: 108 (8%) patients had clinical signs of pulmonary congestion. Within the mean follow-up period of 23 months (SD 4) 67 patients died, mainly within the first 6 months. Of 108 patients with pulmonary congestion, 82 (76%) had coronary and 26 (24%) had non-coronary chest pain. Pulmonary congestion was independently associated with mortality in patients with coronary chest pain (hazard ratio 6.4, 95% confidence interval 2.5 to 16.1, p < 0.0001), both in patients with acute coronary syndromes or angina pectoris. However, in patients with non-coronary chest pain we observed no independent association of pulmonary congestion with outcome. CONCLUSION: Clinical signs of pulmonary congestion indicate an increased risk for poor outcome in patients with chest pain due to myocardial ischemia. Mortality of these patients is high, particularly in the first months after presentation. Therefore, hospital admission is warranted, including patients with angina pectoris, who otherwise may be candidates for early discharge. 相似文献
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79.
Nadler SF Moley P Malanga GA Rubbani M Prybicien M Feinberg JH 《Archives of physical medicine and rehabilitation》2002,83(12):1753-1758
OBJECTIVE: To evaluate whether athletes with a history of low back pain (LBP) would, on average, perform slower on a timed 20-m shuttle run as compared with a normal athletic population. DESIGN: A timed shuttle run to evaluate residual functional limitations in college athletes with resolved LBP. SETTING: National College Athletic Association (NCAA) division I college. PARTICIPANTS: NCAA division I athletes (161 men, 50 women). INTERVENTION: A timed 20-m shuttle run. MAIN OUTCOME MEASURE: Each athlete was timed in a divided 20 m (66 ft) run in which 2 taped lines were positioned 6.7 m (22 ft) apart. RESULTS: Of 211 athletes evaluated, 27 had been treated for LBP during the previous year. Currently asymptomatic athletes with a recent history of LBP were slower (6.3s vs 5.8s) during performance of the timed 20-m shuttle run than athletes without LBP (P=.0002). CONCLUSIONS: Athletes with resolved LBP were slower than a matched group of normal athletes without LBP in the timed 20-m shuttle run. Further research is needed to support these findings and to understand fully the influence of the kinetic chain and the effects of both gender and sport on the observed findings. 相似文献
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