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91.
92.
Maria?Concetta?FargnoliEmail author Gianfranco?Altomare Elisa?Benati Francesco?Borgia Paolo?Broganelli Anna?Carbone Sergio?Chimenti Sergio?Donato Giampiero?Girolomoni Giuseppe?Micali Erica?Moggio Aurora?Parodi Stefano?Piaserico Giuseppe?Pistone Concetta?Potenza Mario?Puviani Margherita?Raucci Sabina?Vaccari Stefano?Veglio Andrea?Zanca Ketty?Peris 《European journal of dermatology : EJD》2017,27(6):599-608
Background
Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia.Objective
To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics.Materials & methods
This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented.Results
AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95% CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95% CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors.Conclusions
AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.93.
Cox SN Sallustio F Serino G Loverre A Pesce F Gigante M Zaza G Stifanelli PF Ancona N Schena FP 《Kidney international》2012,82(5):548-560
A hallmark of immunoglobulin A nephropathy (IgAN) is episodes of gross hematuria coinciding with mucosal infections that can represent the disease-triggering event. Here we performed a whole genomic screen of IgAN patients during gross hematuria to clarify the link between mucosal antigens and glomerular hematuria. Modulated genes showed a clear involvement of the intracellular interferon signaling, antigen-presenting pathway, and the immunoproteasome. The mRNA and protein level of the chemokine receptor characterizing cytotoxic effector lymphocytes, CX3CR1, was upregulated. In vitro antigenic stimulation of peripheral blood mononuclear cells from IgAN patients, healthy blood donors, and other nephropathies with microscopic hematuria showed that only in IgAN patients was CX3CR1 enhanced in a dose-dependent manner. A significantly higher amount of glomerular and urinary fractalkine, the only ligand of CX3CR1, was also found in IgAN patients with recurrent episodes of gross hematuria compared with other patients with microscopic or no hematuria. This suggests a predisposition for cytotoxic cell extravasation only in patients with recurrent gross hematuria. Thus, we found a defect in antigen handling in peripheral blood mononuclear cells of IgAN patients with a specific increase of CX3CR1. This constitutive upregulation of glomerular and urinary fractalkine suggests an involvement of the CX3CR1-fractalkine axis in the exacerbation of gross hematuria. 相似文献
94.
Assessment of early occlusal caries pre‐ and post‐ sealant application—An imaging approach 下载免费PDF全文
95.
Crispino P Pica R Angelucci E Consolazio A Rivera M Cassieri C Paoluzi P 《International journal of colorectal disease》2007,22(5):553-558
Several forms of primary and secondary hematological malignancies were rarely observed during the clinical course of inflammatory
bowel diseases (IBD). Patients needing a prolonged treatment with immunosuppressants, such as azathioprine or methotrexate,
with familiarity and genetic predisposition seem to be at a higher risk of leukemia. On the other hand, asthenia, thickness,
and fever may be the symptoms of the onset of each kind of hematological malignancy. The finding of anemia, alteration of
leukocyte count and large undetermined cells may suggest increased probability of abnormal proliferation of a single white
blood cell line. In this report, the occurrence of hematological malignancies is described in five patients affected by IBD
(three with ulcerative colitis and two with Crohn’s disease) attending our Gastroenterology Unit. 相似文献
96.
Coppola A Coppola L Luongo C Arciello A Cacciapuoti F Lama D Luongo M Ruggiero L Pastore A Gombos G 《The International journal of angiology》2007,16(1):7-11
Ozonized autohemotransfusion has been used as a complementary therapy in patients with peripheral arterial disease (PAD). To determine whether ozone therapy could acutely modify artery vasodilatory capacity, a flow-mediated dilation test was performed at the brachial artery level before and after an ozonized autohemotransfusion in 16 patients with PAD, mean (± SD) age 55±1.8 years, and 14 healthy volunteers matched for age, sex and body mass index. Before ozonized autohemotransfusion, the mean baseline diameter of the brachial artery was higher in PAD patients than in healthy subjects (4.6±0.54 mm versus 3.6±0.54 mm, P<0.001) while mean flow-mediated brachial artery dilation and percentage of increase in flow were significantly lower in PAD patients than in controls (6.3±6.1% versus 11.8±2.4%, P<0.02; 433±61% versus 580±46%, P<0.02, respectively). No significant changes were observed after ozonized autohemotransfusion, indicating that ozonized autohemotransfusion does not modify endothelium-dependent ischemia-induced vascular reactivity. 相似文献
97.
Sergio Daga Jie Ding Constantinos Deltas Judy Savige Beata S. Lipska-Zitkiewicz Julia Hoefele Frances Flinter Daniel P. Gale Marina Aksenova Hirofumi Kai Laura Perin Moumita Barua Roser Torra Jeff H. Miner Laura Massella Danica Galei Ljubanovi Rachel Lennon Andr B. Weinstock Bertrand Knebelmann Agne Cerkauskaite Susie Gear Oliver Gross A. Neil Turner Margherita Baldassarri Anna Maria Pinto Alessandra Renieri 《European journal of human genetics : EJHG》2022,30(5):507
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