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101.
Marcos C. De Almeida Damian Sanchez-Quintana Robert H. Anderson 《Anatomical science international / Japanese Association of Anatomists》2020,95(3):381-386
Sunao Tawara, who was born in 1873 and died in 1952, is considered the father of modern cardiac electrophysiology. He published his monumental monograph de 相似文献
102.
Marcos Aurélio Barboza de Oliveira Ant?nio Carlos Brandi Carlos Alberto dos Santos Paulo Henrique Husseni Botelho José Luís Lasso Cortez Gilberto Goissis Domingo Marcolino Braile 《Brazilian Journal Of Cardiovascular Surgery》2014,29(2):249-254
The calcium paradox was first mentioned in 1966 by Zimmerman et al. Thereafter gained
great interest from the scientific community due to the fact of the absence of
calcium ions in heart muscle cells produce damage similar to ischemia-reperfusion.
Although not all known mechanisms involved in cellular injury in the calcium paradox
intercellular connection maintained only by nexus seems to have a
key role in cellular fragmentation. The addition of small concentrations of calcium,
calcium channel blockers, and hyponatraemia hypothermia are important to prevent any
cellular damage during reperfusion solutions with physiological concentration of
calcium. 相似文献
103.
Clinical validation of the nursing diagnosis of ineffective protection in haemodialysis patients
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Jéssica Dantas de Sá Tinôco RN MsN Maria das Graças Mariano Nunes de Paiva RN MsN Kadyjina Daiane Batista Lucio RN Maria Isabel da Conceição Dias Fernandes RN MsN Marcos Venicios de Oliveira Lopes RN MsN PhD Ana Luisa Brandão de Carvalho Lira RN MsN PhD 《Journal of clinical nursing》2018,27(1-2):e195-e202
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Vikram Kilambi F. Reed Johnson Juan Marcos González Ateesha F. Mohamed 《Value in health》2014,17(8):838-845
BackgroundThe value of the information that genetic testing services provide can be questioned for insurance-based health systems. The results of genetic tests oftentimes may not lead to well-defined clinical interventions; however, Lynch syndrome, a genetic mutation for which carriers are at an increased risk for colorectal cancer, can be identified through genetic testing, and meaningful health interventions are available via increased colonoscopic surveillance. Valuations of test information for such conditions ought to account for the full impact of interventions and contingent outcomes.ObjectivesTo conduct a discrete-choice experiment to elicit individuals’ preferences for genetic test information.MethodsA Web-enabled discrete-choice experiment survey was administered to a representative sample of US residents aged 50 years and older. In addition to specifying expenditures on colonoscopies, respondents were asked to make a series of nine selections between two hypothetical genetic tests or a no-test option under the premise that a relative had Lynch syndrome. The hypothetical genetic tests were defined by the probability of developing colorectal cancer, the probability of a false-negative test result, privacy of the result, and out-of-pocket cost. A model specification identifying necessary interactions was derived from assumptions of risk behavior and the decision context and was estimated using random-parameters logit.ResultsA total of 650 respondents were contacted, and 385 completed the survey. The monetary equivalent of test information was approximately $1800. Expenditures on colonoscopies to reduce mortality risks affected valuations. Respondents with lower income or who reported being employed significantly valued genetic tests more.ConclusionGenetic testing may confer benefits through the impact of subsequent interventions on private individuals. 相似文献
106.
Giammaria Fiorentini Camillo Aliberti Donatella Sarti Paolo Coschiera Massimo Tilli Luca Mulazzani Paolo Giordani Francesco Graziano Alfonso Marqués Gonzalez Raul García Marcos Fernando Gómez Mugnoz Maurizio Cantore Stefano Ricci Vincenzo Catalano Andrea Mambrini 《World journal of gastrointestinal oncology》2015,7(6):47-54
AIM: To investigate efficacy and safety of second-line treatment with irinotecan-loaded drug-eluting beads (DEBIRI) and cetuximab (DEBIRITUX) of unresectable colorectal liver metastases.METHODS: Patients with the following characteristics were included in the study: unresectable hepatic metastases from colorectal carcinoma (CRC-LM), progression after first line chemotherapy (any type of chemotherapeutic drug and combination was allowed), second line treatment (mandatory), which included for each patient (unregarding the KRas status) two cycles of DEBIRI (using 100-300 μm beads loaded with irinotecan at a total dose 200 mg) followed by 12 cycles of cetuximab that was administered weekly at a first dose of 400 mg/m2 and then 250 mg/m2; good performance status (0-2) and liver functionality (alanine aminotransferase and gamma-glutamyl transferase not exceeding three times the upper limit of normal, total bilirubin not exceeding 2.5 mg/mL). Data were collected retrospectively and included: tumor response (evaluated monthly for 6 mo then every 3 mo), overall response rate (ORR), KRas status, type and intensity of adverse events (G according to the Common Terminology Criteria for Adverse Events v3.0, CTCAE), overall survival (OS) and progression free survival (PFS).RESULTS: Forty consecutive cases of CRC hepatic metastases were included in the study. Median duration of DEBIRITUX was 4.4 mo (range, 4.0-6.5). Sixteen patients (40%) received the planned 2 cycles of DEBIRI and an average of 10 cetuximab cycles. ORR of the whole sample was 50%, in particular 4 patients were complete responders (10%) and 16 (40%) partial responders. The most observed side effects (G2) were: post-embolization syndrome (30%), diarrhea (25%), skin rushes (38%) and asthenia (35%). The retrospective evaluation of KRas status (24 wild type, 16 mutated) showed that the group of patients with wild type KRas had ORR significantly higher than mutant KRas. Median follow-up was 29 mo (8-48 range); median PFS was 9.8 mo and OS was 20.4 mo. Future randomized trials are required in this setting to establish a role for DEBIRITUX compared with systemic chemotherapy.CONCLUSION: DEBIRITUX seems to be efficacious after first line chemotherapy for the treatment of unresectable CRC-LM. 相似文献
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109.
Ana Faraldo-García Sofía Santos-Pérez Marcos Rossi-Izquierdo Antonio Lirola-Delgado Isabel Vaamonde-Sánchez-Andrade María del-Río-Valeiras 《Acta oto-laryngologica》2016,136(11):1125-1129
Conclusions: There was a difference in average score of the sensory organization test (SOT) of the case group (elderly instability) compared to the control group (healthy subjects). Cases had worse scores on the limits of stability (LOS) than controls, but were only able to confirm statistically significant differences in the movement velocity.Objective: To study the LOS of elderly patients with instability vs healthy subjects of the same age to try to explain the increased risk of falls in elderly patients with instability.Methods: Fifty individuals ≥65 years, 30 cases (at least one of the next inclusion criteria: ≥1 fall in the last 12 months, >15?s or some support in the timed up and go test, composite <68 in SOT, ≥1 fall during production of the SOT) compared to 20 controls. Postural study: SOT and LOS, Smart Equitest Neurocom® platform. Statistical analysis: t-Student test (p?0.05).Result: Mean value of overall balance: patients with instability =56% vs controls =77.1% (p 0.001). Movement velocity: cases =2243°/s vs controls =2860°/s (p?=?0.029). The reaction time (cases =1217?s vs controls =1.077?s), excursion (56.95% vs 59.35%) and directional control (56.95% vs 59.35%) differences were not statistically significant. 相似文献
110.
Prognostic clinical indicators of short‐term survival for ineffective breathing pattern in children with acute respiratory infection
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