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101.
Vera Manageiro Eugénia Ferreira Joana Almeida Stephanie Barbosa Constan?a Sim?es Antibiotic Resistance Surveillance Program in Portugal Robert A. Bonomo Manuela Cani?a 《Antimicrobial agents and chemotherapy》2015,59(6):3588-3592
Among the 2,105 Enterobacteriaceae tested in a survey done in Portugal, 165 were nonsusceptible to carbapenems, from which 35 (26 Klebsiella pneumoniae, 3 Escherichia coli, 2 Enterobacter aerogenes, and 3 Enterobacter cloacae isolates and 1 Klebsiella oxytoca isolate) were confirmed to be carbapenemase producers by the presence of 30 Tn4401d-blaKPC-3, 4 intI3-blaGES-5, and one intI1-blaVIM-2 gene, alone or in combination with other bla genes. The dissemination of blaKPC-3 gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination. 相似文献
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Alessandra Mangia Tivadar Bányai Giuseppe De Bartolomeo Judit Gervain François Habersetzer Jean‐Pierre Mulkay Denis Ouzan Giustino Parruti Nicola Passariello Andre‐Jean Remy Mario Rizzetto Mitchell L. Shiffman Manuela Schmitz Fernando Tatsch Maribel Rodriguez‐Torres 《Liver international》2014,34(7):e217-e228
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B. Katherine Poole-Smith Alexa Gilbert Andrea L. Gonzalez Manuela Beltran Kay M. Tomashek Brian J. Ward Elizabeth A. Hunsperger Momar Ndao 《The American journal of tropical medicine and hygiene》2014,91(6):1218-1226
Half a million patients are hospitalized with severe dengue every year, many of whom would die without timely, appropriate clinical intervention. The majority of dengue cases are uncomplicated; however, 2–5% progress to severe dengue. Severe dengue cases have been reported with increasing frequency over the last 30 years. To discover biomarkers for severe dengue, we used surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to analyze dengue virus positive serum samples from the acute phase of infection. Using this method, 16 proteins were identified as candidate biomarkers for severe dengue. From these 16 biomarkers, three candidates were selected for confirmation by enzyme-linked immunosorbent assay and Western blot: vitronectin (Vtn, 55.1 kDa), hemopexin (Hx, 52.4 kDa), and serotransferrin (Tf, 79.2 kDa). Vitronectin, Hx, and Tf best differentiated between dengue and severe dengue. 相似文献
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Luis C. L. Correia Guilherme Garcia Felipe Kalil Felipe Ferreira Manuela Carvalhal Ruan Oliveira André Silva Isis Vasconcelos Caio Henri Márcia Noya-Rabelo 《Arquivos brasileiros de cardiologia》2014,103(2):98-106
Background
The TIMI Score for ST-segment elevation myocardial infarction (STEMI) was created and validated specifically for this clinical scenario, while the GRACE score is generic to any type of acute coronary syndrome.Objective
Between TIMI and GRACE scores, identify the one of better prognostic performance in patients with STEMI.Methods
We included 152 individuals consecutively admitted for STEMI. The TIMI and GRACE scores were tested for their discriminatory ability (C-statistics) and calibration (Hosmer-Lemeshow) in relation to hospital death.Results
The TIMI score showed equal distribution of patients in the ranges of low, intermediate and high risk (39 %, 27 % and 34 %, respectively), as opposed to the GRACE Score that showed predominant distribution at low risk (80 %, 13 % and 7%, respectively). Case-fatality was 11%. The C-statistics of the TIMI score was 0.87 (95%CI = 0.76 to 0.98), similar to GRACE (0.87, 95%CI = 0.75 to 0.99) - p = 0.71. The TIMI score showed satisfactory calibration represented by χ2 = 1.4 (p = 0.92), well above the calibration of the GRACE score, which showed χ2 = 14 (p = 0.08). This calibration is reflected in the expected incidence ranges for low, intermediate and high risk, according to the TIMI score (0 %, 4.9 % and 25 %, respectively), differently to GRACE (2.4%, 25% and 73%), which featured middle range incidence inappropriately.Conclusion
Although the scores show similar discriminatory capacity for hospital death, the TIMI score had better calibration than GRACE. These findings need to be validated populations of different risk profiles. 相似文献108.
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110.
Semmler-Behnke M Kreyling WG Schulz H Takenaka S Butler JP Henry FS Tsuda A 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(13):5092-5097
The lung surface is an ideal pathway to the bloodstream for nanoparticle-based drug delivery. Thus far, research has focused on the lungs of adults, and little is known about nanoparticle behavior in the immature lungs of infants. Here, using nonlinear dynamical systems analysis and in vivo experimentation in developing animals, we show that nanoparticle deposition in postnatally developing lungs peaks at the end of bulk alveolation. This finding suggests a unique paradigm, consistent with the emerging theory that as alveoli form through secondary septation, alveolar flow becomes chaotic and chaotic mixing kicks in, significantly enhancing particle deposition. This finding has significant implications for the application of nanoparticle-based inhalation therapeutics in young children with immature lungs from birth to 2 y of age. 相似文献