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51.
Yoshino Okuma Austin J. Bergquist Mandy Hong K. Ming Chan David F. Collins 《Clinical neurophysiology》2013,124(11):2257-2263
Objective
To compare the spatial distribution of motor units recruited in tibialis anterior (TA) when electrical stimulation is applied over the TA muscle belly versus the common peroneal nerve trunk.Methods
Electromyography (EMG) was recorded from the surface and from fine wires in superficial and deep regions of TA. Separate M-wave recruitment curves were constructed for muscle belly and nerve trunk stimulation.Results
During muscle belly stimulation, significantly more current was required to generate M-waves that were 5% of the maximal M-wave (Mmax; M5%max), 50% Mmax (M50%max) and 95% Mmax (M95%max) at the deep versus the superficial recording site. In contrast, during nerve trunk stimulation, there were no differences in the current required to reach M5%max, M50%max or M95%max between deep and superficial recording sites. Surface EMG reflected activity in both superficial and deep muscle regions.Conclusions
Stimulation over the muscle belly recruited motor units from superficial to deep with increasing stimulation amplitude. Stimulation over the nerve trunk recruited superficial and deep motor units equally, regardless of stimulation amplitude.Significance
These results support the idea that where electrical stimulation is applied markedly affects how contractions are produced and have implications for the interpretation of surface EMG data. 相似文献52.
Robert A. Power Sarah Cohen‐Woods Mandy Y. Ng Amy W. Butler Nick Craddock Ania Korszun Lisa Jones Ian Jones Michael Gill John P. Rice Wolfgang Maier Astrid Zobel Ole Mors Anna Placentino Marcella Rietschel Katherine J. Aitchison Federica Tozzi Pierandrea Muglia Gerome Breen Anne E. Farmer Peter McGuffin Cathryn M. Lewis Rudolf Uher 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2013,162(6):521-529
53.
Katz AR Komeya AY Soge OO Kiaha MI Lee MV Wasserman GM Maningas EV Whelen AC Kirkcaldy RD Shapiro SJ Bolan GA Holmes KK 《Clinical infectious diseases》2012,54(6):841-843
We report on the first Neisseria gonorrhoeae isolate in the United States identified with high-level resistance to azithromycin. This report discusses the epidemiologic case investigation, the molecular studies of resistance-associated mutations and N. gonorrhoeae multiantigen sequence typing, and challenges posed by emerging gonococcal antimicrobial resistance. 相似文献
54.
55.
André Miersch Mandy Vogel Ruth Gausche Werner Siekmeyer Roland Pfäffle Katalin Dittrich Wieland Kiess 《Pediatric nephrology (Berlin, Germany)》2013,28(12):2351-2359
Background
High blood pressure is a major risk factor for cardiovascular disease. Blood pressure tracking could help to identify individuals with potential hypertension. Therefore, we have asked whether or not tracking was of predictive value for the development of hypertension in early life.Methods
Blood pressure was routinely measured in 13,261 children and adolescents in outpatient clinics as well as during hospitalization. In one analysis, 568 individuals with elevated and normotensive blood pressure values were evaluated after 2, 4, and 6 years of follow-up. In a second analysis, 2,157 individuals with normotensive blood pressure were examined in a paired t test.Results
The follow-up analysis showed a significant tracking effect. However, the Pearson correlation coefficients of the systolic and diastolic blood pressure standard deviation scores (SDS) decreased over time. Upon the follow-up after 6 years, 35.6 % of the children and adolescents with elevated blood pressure values remained in the elevated range group. Of the children within the normotensive blood pressure range, 80.4 % remained normotensive after 6 years. Children with normotensive blood pressure showed a stronger tracking than those who had had one hypertensive blood pressure reading. Children with higher body mass index (BMI) at follow-up changed blood pressure SDS track from initially normal to higher blood pressure values.Conclusions
Blood pressure tracking in children and adolescents is moderate. We conclude that the predictive power of a single hypertensive blood pressure measurement during a single visit is rather small, and thus repetitive measurements across several consecutive visits are necessary. 相似文献56.
Mandy Mangler Isabel Trebesch de Perez Bianca Teegen Winfried Stöcker Harald Prüss Andreas Meisel Achim Schneider Jekaterina Vasiljeva Dorothee Speiser 《Journal of neurology》2013,260(11):2831-2835
Recently antibodies against neuronal receptors have been identified as cause of a new type of encephalitis. The anti-N-methyl-d-aspartate receptor (anti-NMDA-R) encephalitis is the prototype of these disorders. Patients have a high incidence of teratomata. Removal of teratoma is considered the essential treatment of anti-NMDA-R encephalitis. Here, we aimed to investigate whether neurologically asymptomatic individuals suffering from ovarian teratomata may have positive anti-NMDA-R antibodies to be detected by an established assay. Over a time period of 15 months, all patients suffering from ovarian teratomata without neurological symptoms were included in this prospective study. Twenty consecutive patients were pair matched to patients with other benign ovarian disease and healthy controls. Preoperatively, patients had a gynaecological examination, transvaginal ultrasound, neurological examination and determination of anti-NMDA-R antibodies. None of the patients or controls presented with neurological symptoms. All tumours could be removed completely by laparoscopy. Anti-NMDA-R antibodies were absent in the group of patients with teratomata as well as in patients with benign ovarian tumours and healthy controls. Testing for anti-NMDA-R antibodies revealed negative findings in well-characterised patients with ovarian teratomata lacking neurological symptoms. Our data support the current clinical practice that a systematic screening for anti-NMDA-R antibodies in teratoma patients is not indicated. 相似文献
57.
Debora M. Kagohara Larah van der Meer Sathiyaprakash Ramdoss Mark F. O’Reilly Giulio E. Lancioni Tonya N. Davis Mandy Rispoli Russell Lang Peter B. Marschik Dean Sutherland Vanessa A. Green Jeff Sigafoos 《Research in developmental disabilities》2013,34(1):147-156
We conducted a systematic review of studies that involved iPods®, iPads®, and related devices (e.g., iPhones®) in teaching programs for individuals with developmental disabilities. The search yielded 15 studies covering five domains: (a) academic, (b) communication, (c) employment, (d) leisure, and (e) transitioning across school settings. The 15 studies reported outcomes for 47 participants, who ranged from 4 to 27 years of age and had a diagnosis of autism spectrum disorder (ASD) and/or intellectual disability. Most studies involved the use of iPods® or iPads® and aimed to either (a) deliver instructional prompts via the iPod Touch® or iPad®, or (b) teach the person to operate an iPod Touch® or iPad® to access preferred stimuli. The latter also included operating an iPod Touch® or an iPad® as a speech-generating device (SGD) to request preferred stimuli. The results of these 15 studies were largely positive, suggesting that iPods®, iPod Touch®, iPads®, and related devices are viable technological aids for individuals with developmental disabilities. 相似文献
58.
Maximilian Methling Franziska Krumbiegel Sven Hartwig Maria K. Parr Michael Tsokos 《Forensic science, medicine, and pathology》2019,15(1):23-30
The role of psychoactive substances in the treatment of mental disorders and the risk of suicide are major public health issues. This cross-sectional study examined the prevalence of antidepressants and antipsychotics detected in toxicological screenings in suicides. Cases from the Institute of Legal Medicine of the Charité-University Medicine Berlin were reviewed over a 4-year-period. All cases (n = 477) with positive toxicology for antidepressants and antipsychotics in blood or organ tissue were included. Frequencies of the detected substances in non-suicide cases (n = 212; male n = 177, 55.2%; female n = 95, 52.5%) and suicide cases (n = 235; male n = 149, 63.4%; female n = 86, 36.6%) were examined. Tricyclic antidepressants (48.1%) were found most frequently in suicides, followed by atypical neuroleptics (37.0%), selective serotonin reuptake inhibitors (28.1%), typical neuroleptics (17.4%), tetracyclic antidepressants (16.2%) and other substances (8.9%). Alcohol was detected in 37.2% of suicides. The leading cause of death was drug poisoning (35.6%) followed by polytrauma (26.8%) and death by hanging (18.5%). A mental disorder (depression, schizophrenia, bipolar disorder, suicidality) was known in 22.9% of suicides. The most common location of death was the person’s own house (63.8%) followed by public places (28.1%) and hospitals (8.1%) The five most common substances in the suicide group were doxepin (20%) citalopram (15.3%), mirtazapine (14.9%), quetiapine (13.6%) and amitriptyline (12.3%). Toxicological findings from cross-sectional studies provide insight into how often certain types of antidepressants and antipsychotics are associated with suicide. A complementary approach is valuable for assessing the risk of suicide during medical treatment because the various available approaches (analysis of suicidal behavior/ideation, toxicity of drugs) each have strengths and limitations. 相似文献
59.
Understanding Camouflaging as a Response to Autism-Related Stigma: A Social Identity Theory Approach
Perry Ella Mandy William Hull Laura Cage Eilidh 《Journal of autism and developmental disorders》2022,52(2):800-810
Journal of Autism and Developmental Disorders - Camouflaging refers to strategies used by autistic people to mask or hide social difficulties. The current study draws on Social Identity Theory to... 相似文献
60.
Yana Puckett Jose Greenspon Colleen Fitzpatrick Dennis Vane Samiksha Bansal Mandy Rice Kaveer Chatoorgoon 《Pediatric surgery international》2016,32(8):805-809