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981.
F.?SelcukbiricikEmail author M.?Kanbay Y.?Solak A.?Bilici M.?Kan?tez E.?Bal?k N.?M.?Mandel 《Clinical & translational oncology》2016,18(11):1082-1087
Bevacizumab is a monoclonal antibody which is a vascular endothelial growth factor inhibitor. It obscures vascularization of tumor tissue and damages intratumoral microcirculation. The damaged intratumoral microcirculation leads to tissue hypoxia and results in increase of uric acid level. The main aim of our study was to investigate the relationship between uric acid change and response to bevacizumab therapy. This study included a total of 158 patients with metastatic colorectal cancer who had received bevacizumab therapy. The number of male patients was 100 (63.3 %) while female patients number was 58 (37.7 %). The median age was 61 (29–83). There was relationship between increase of uric acid level of third month uric acid level and stable disease (p < 0.001). There was a significant overall survival increased in the group with increased uric acid level (p < 0.001). The decline of CEA level was related to uric acid level (p < 0.022). In conclusion, this study is the first showing significant increases of serum uric acid in patients with metastatic colorectal cancer who favorably responded to chemotherapy with bevacizumab. But further studies are justified to test whether monitoring uric acid levels might predict clinical outcomes of patients with metastatic colorectal cancer. 相似文献
982.
Periodontal status of patients with reduced immunocapacity. 总被引:2,自引:0,他引:2
The periodontal status of patients with reduced immunocapacity was assessed. Gingival inflammation, periodontal destruction, and plaque accumulation were compared in three groups--renal transplant patients, dialysis patients, and normal individuals. The levels of all parameters were similar in the three groups indicating that immunosuppression does not affect the clinical appearance of periodontal disease when measurements are made in a single examination. In the transplant group, however, there is a lack of correlation between P.I. and G.I. and between P.I. and P.D.I., indicating a dissociation between plaque accumulation and the tissue response. Long-term longitudinal studies of periodontal disease in such patients are needed in order to obtain more meaningful information on the role of the immune system in affecting the rate of periodontal destruction. This study suggests that nonimmune mechanisms such as the direct effect of bacterial products on supporting tissues can account for at least some of the clinical manifestations of periodontal disease. 相似文献
983.
Columbia University's Salivary Gland Center (SGC) has examined more than 6,000 patients with a variety of concerns stemming from salivary gland disease and/or salivary secretory dysfunction. Not unexpectedly, the most common patient complaint centers around symptoms associated with dry mouth. Such patients are usually first seen by the dental practitioner. Because Sj?gren's syndrome (SS) causes dry mouth, and because it is a relatively common entity--encountered in about three million Americans--and because the dental profession has become aware of its classic manifestation of xerostomia, patients experiencing SS are referred in increasing numbers to the SGC for evaluation. Therefore, the authors wish to call attention to the methodology used in accurately diagnosing SS and to illustrate its signs and symptoms with a case report. 相似文献
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986.
This oftentimes underappreciated disease carries with it severe dental implications, all of which can affect the patient's quality of life. While there is no cure, it is possible to manage disease symptoms and to prevent irreversible dental damage. 相似文献
987.
Cytomegalovirus presence and salivary composition in acquired immunodeficiency syndrome 总被引:2,自引:0,他引:2
Parotid and whole saliva was collected from nine patients with acquired immunodeficiency syndrome (AIDS) and nine controls. Cytomegalovirus (CMV) was cultured from both salivary samples in six of the AIDS patients but was not present in any of the controls. In the AIDS samples parotid sodium (p less than 0.05), IgG (p less than 0.01), and albumin (p less than 0.05) were higher than in control samples. Parotid potassium (p less than 0.05) and total protein (p less than 0.05) were lower than control values, whereas flow rate, lactoferrin, lysozyme, IgA, and IgM levels were similar in both sets of samples. AIDS does not appear to affect secretory IgA levels. Sodium (p less than 0.01) and IgA (p less than 0.05) were higher in the whole saliva of AIDS patients. Serum IgG, IgM (p less than 0.01), and IgA (p less than 0.05) were also elevated when compared with the controls. The prevalence of CMV in parotid and whole saliva of AIDS patients is consistent with the known susceptibility of this group to adventitious infection and the predilection of this virus for the salivary glands. The changes in salivary composition suggest a low level of inflammation, which occurs independently of the virus. 相似文献
988.
989.
Recommendations for a step‐wise comparative approach to the evaluation of new screening tests for colorectal cancer
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Graeme P. Young MD FRACP FTSE AGAF Carlo Senore MD MSc Jack S. Mandel PhD MPH James E. Allison MD FACP AGAF Wendy S. Atkin MPH PhD Robert Benamouzig MD PhD Patrick M. M. Bossuyt PhD Mahinda De Silva MB BS FRACP Lydia Guittet MD PhD Stephen P. Halloran MBE FRCPath Ulrike Haug PhD Geir Hoff MB ChB PhD Steven H. Itzkowitz MD FACP FACG AGAF Marcis Leja MD MBA PhD AGAF Bernard Levin MB BCh FACP Gerrit A. Meijer MD PhD Colm A. O'Morain MD Susan Parry MbCHB FRACP Linda Rabeneck MD MPH FRCPC Hiroshi Saito MD PhD Robert E. Schoen MD MPH Helen E. Seaman BSc PhD Robert J. C. Steele MD FRCS Joseph J. Y. Sung MD PhD Sidney J. Winawer MD 《Cancer》2016,122(6):826-839
990.
Xuan-Anh Phi Sepideh Saadatmand Geertruida H De Bock Ellen Warner Francesco Sardanelli Martin O Leach Christopher C Riedl Isabelle Trop Maartje J Hooning Rodica Mandel Filippo Santoro Gek Kwan-Lim Thomas H Helbich Madeleine MA Tilanus-Linthorst Edwin R van den Heuvel Nehmat Houssami 《British journal of cancer》2016,114(6):631-637