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81.
SV Lourenço TP Hussein SB Bologna AM Sipahi MMS Nico 《Journal of the European Academy of Dermatology and Venereology》2010,24(2):204-207
Inflammatory bowel disease (IBD) comprises two chronic, tissue‐destructive, clinical entities: Crohn's disease (CD) and ulcerative colitis (UC), both immunologically based. Bowel symptoms are predominant, but extra‐intestinal complications may occur, including involvement of the oral cavity. Oral involvement during IBD includes several types of lesions: the most common are aphthae; uncommon lesions include, among others, pyostomatitis vegetans and granulomatous lesions of CD. Starting with a presentation of six patients with oral manifestations, which were crucial for the final diagnosis of IBD, a review on the subject is presented. Oral involvement in IBD may be previous or simultaneous to the gastrointestinal symptoms. However, in the majority of cases, bowel disease precedes the onset of oral lesions by months or years. In many patients, the intestinal symptoms may be minimal and can go undetected; thus, most authors believe that the bowel must be thoroughly examined in all patients with suspected IBD even in the absence of specific symptoms. Usually, the clinical course of oral lesions is parallel to the activity of IBD; therefore, oral manifestations are a good cutaneous marker of IBD. 相似文献
82.
Aĭzenberg VL Ul'rikh GE Ukolov KIu Zabolotskiĭ DV Ivanov MD Malashenko NS 《Anesteziologiia i reanimatologiia》2011,(1):59-62
The research is based upon comparative evaluation of methods of analgesia in 107 patients after surgical correction of scoliotic spinal deformities, which were divided into three comparable groups. The quality of analgesia was assessed on the basis of the clinical manifestations, central hemodynamic changes and total score of pain intensity on. With a combination of narcotic and non-narcotic analgesics (group 1), adequate blockade of nociceptive impulses and comfort of the child are not being reached. Postoperative wound irrigation with 0.1 - 0.2% solution of ropivacaine in combination with NSAIDs is more effective (group 2), if the length of the wound does not exceed 20-23 cm. This method reduces vomiting after surgery and is applied if the patient has not received epidural analgesia. The best effect is achieved with the constant introduction of 0.2% solution of ropivacaine into the epidural space (group 3). This method provides adequate analgesia, sympathetic blockade, and a comfortable postoperative period. It allows the earlier feeding, reduces the incidence of vomiting and can be considered the method of choice. 相似文献
83.
Rajesh Kumar Hemant Gupta Anil Jadhav SV Khadilkar 《Indian journal of dermatology》2013,58(4):328-Aug;58(4):328
A 74-year-old man was presented with fever, bilateral throbbing temporoparietal headache, jaw claudication, and bilateral loss of vision. On examination, he had bilateral scalp necrosis with impending necrosis of lip and tongue. Temporal artery biopsy was done, and it was compatible with active temporal arteritis. This is one of the rare presentations of giant cell arteritis where there is simultaneous necrosis of scalp, lip, and tongue, and to the best of our knowledge, it is the first case reported from India. 相似文献
84.
de Matos GF Stanzani F Passos RH Fontana MF Albaladejo R Caserta RE Santos DC Borges JB Amato MB Barbas CS 《Critical care (London, England)》2012,16(1):R4
Introduction
The benefits of higher positive end expiratory pressure (PEEP) in patients with acute respiratory distress syndrome (ARDS) have been modest, but few studies have fully tested the "open-lung hypothesis". This hypothesis states that most of the collapsed lung tissue observed in ARDS can be reversed at an acceptable clinical cost, potentially resulting in better lung protection, but requiring more intensive maneuvers. The short-/middle-term efficacy of a maximum recruitment strategy (MRS) was recently described in a small physiological study. The present study extends those results, describing a case-series of non-selected patients with early, severe ARDS submitted to MRS and followed until hospital discharge or death. 相似文献85.
A. A. Smirnov N. V. Shishova N. Yu. Sakharova A. M. Malashenko I. I. Selezneva B. K. Gavrilyuk 《Bulletin of experimental biology and medicine》2008,145(1):146-150
The localization of enhanced green fluorescent protein (EGFP) was studied in preimplantation embryos obtained from reciprocal
mating of hemizygous C57Bl/6-Tgn (ACTbEGFP)1Osb/J mice with C57Bl/6 mice. Specific fluorescence of EGFP was observed in all
oocytes and embryos obtained from transgenic females during all preimplantation stages and in embryos inheriting the EGFP
gene from transgenic males starting from the 8 blastomere stage during the compactization period. EGFP mRNA or EGFP synthesized
during oogenesis can be retained in embryos during the entire preimplantation period, while expression of EGFP gene transferred
from the father coincides with the onset of compactization. The possibility of using these embryos in experimental mammalian
embryology is discussed.
__________
Translated from Kletochnye Tehnologii v Biologii i Meditsine, No. 1, pp. 39–44, January, 2007 相似文献
86.
87.
Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues
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E‐cigarette‐derived inhaled nicotine may contribute to the pathogenesis of periodontal and pulmonary diseases in particular via lung inflammation, injurious, and dysregulated repair responses. Nicotine is shown to have antiproliferative properties and affects fibroblasts in vitro, which may interfere in tissue myofibroblast differentiation in e‐cig users. This will affect the ability to heal wounds by decreasing wound contraction. In periodontics, direct exposure to e‐vapor has been shown to produce harmful effects in periodontal ligament and gingival fibroblasts in culture. This is due to the generation of reactive oxygen species/aldehydes/carbonyls from e‐cig aerosol, leading to protein carbonylation of extracellular matrix and DNA adducts/damage. A limited number of studies regarding the effects of e‐cig in oral and lung health are available. However, no reports are available to directly link the deleterious effects on e‐cigs, inhaled nicotine, and flavorings aerosol on periodontal and pulmonary health in particular to identify the risk of oral diseases by e‐cigarettes and nicotine aerosols. This mini‐review summarizes the recent perspectives on e‐cigarettes including inhaled nicotine effects on several pathophysiological events, such as oxidative stress, DNA damage, innate host response, inflammation, cellular senescence, profibrogenic and dysregulated repair, leading to lung remodeling, oral submucous fibrosis, and periodontal diseases. 相似文献
88.
Paietta E; Stockert RJ; Calvelli T; Papenhausen P; Seremetis SV; Fotino M; Wiernik PH; Chang L; Bollum FJ 《Blood》1987,70(4):1151-1160
A cell line with immature blast cell morphology was isolated from HL-60 promyelocytic leukemia cell cultures and designated HL-T. This new cell type is biphenotypic, expressing terminal transferase (TdT) together with myelomonocytoid immunologic features. TdT enzymatic activity, undetectable in HL-60, was determined to be 140 to 180 units/10(8) HL-T cells by the dGTP-assay, approximately 20% of the activity found in lymphoblastoid cell lines. HL-T predominantly synthesize the known 58- kDa TdT-protein plus a minor 54/56-kDa doublet. The 58-kDa steady state form is nonglycosylated and is phosphorylated. Precursor antigens S3.13 and MY-10, absent on HL-60, are expressed by HL-T; however, the cells are negative for HLA-Dr. Southern blot analysis by hybridization with immunoglobulin heavy chain (JH) and T cell-receptor chain gene (T beta) probes shows JH to be in the germ-line configuration in both cell lines and the T beta gene to be in germ-line in HL-60 but to be rearranged in HL-T. Truncation of the gene encoding the granulocyte-macrophage-colony- stimulating factor (GM-CSF), as found in HL-60, is not observed in HL- T. HL-T are resistant to differentiation-induction by retinoic acid and 1,25-dihydroxyvitamin D3. Cytogenetically HL-T share with HL-60 a deletion of the short arm of chromosome 9 at breakpoint p13, an aberration frequently found in patients with T cell leukemia. In addition, HL-T display t(8;9)(p11;p24) and trisomy 20. Tetraploidy is observed in 80% of HL-T metaphases with aberrations identical to those in the diploid karyotype. Like HL-60, the new line shows some surface- antigenic-T cell characteristics. Despite an antigenic pattern most consistent with that of helper-inducer T cells (T4+, D44+/-, 4B4+, 2H4- , TQ1+/-), HL-T cells and their conditioned culture medium suppress antigen, mitogen, and mixed-leukocyte-culture-mediated lymphocyte proliferation. 相似文献
89.
90.
Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation 总被引:5,自引:2,他引:5
Scott RJ; Froggatt NJ; Trembath RC; Evans DG; Hodgson SV; Maher ER 《Human molecular genetics》1996,5(12):1921-1924
Desmoid tumours are generally very rare but occur about 100 times more
frequently in the colorectal cancer predisposition syndrome familial
adenomatous polyposis (MIM 175100), being represented in about 10% of
patients. In addition to desmoid disease occurring in familial adenomatous
polyposis (FAP) there exist familial infiltrative fibromatosis (MIM 135290)
kindreds where there is no evidence of FAP. Previously we have described a
kindred with familial infiltrative fibromatosis (FIF) in which desmoid
tumours were associated with nonpolyposis colorectal cancer. FAP is caused
by mutations in the APC gene and various genotype-phenotype relationships
have been defined including reports that colorectal polyposis is less
severe with mutations 5' to codon 157 and that the risk of desmoid tumours
is high in FAP patients with APC gene mutations between codons 1444 and
1598. There is relatively little information on the phenotype of APC gene
mutations 3' to codon 1598; however, one large family has been reported
with a mutation at codon 1987 which presents with a highly variable
phenotype which includes desmoid disease. We screened our original FIF
kindred and three further families with a similar phenotype for mutations
in the APC gene. A 4 bp frameshift deletion in codon 1962 was identified in
the original FIF kindred and two further apparently unrelated families.
Haplotype analysis suggests a common origin for the APC mutation in all
three families. Affected individuals had no evidence of congenital
hypertrophy of the retinal pigment epithelium. Colorectal polyposis was
variable, and most affected patients had either none or a few late onset
polyps. These findings demonstrate (i) that FAP and FIF are allelic, and
(ii) that APC gene mutations which truncate the APC protein distal to the
beta-catenin binding domain are associated with desmoid tumours, absent
CHRPE and variable but attenuated polyposis expression.
相似文献