全文获取类型
收费全文 | 3150篇 |
免费 | 241篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 73篇 |
妇产科学 | 52篇 |
基础医学 | 509篇 |
口腔科学 | 30篇 |
临床医学 | 301篇 |
内科学 | 758篇 |
皮肤病学 | 43篇 |
神经病学 | 210篇 |
特种医学 | 209篇 |
外国民族医学 | 1篇 |
外科学 | 357篇 |
综合类 | 183篇 |
一般理论 | 6篇 |
预防医学 | 233篇 |
眼科学 | 21篇 |
药学 | 213篇 |
1篇 | |
中国医学 | 16篇 |
肿瘤学 | 213篇 |
出版年
2023年 | 20篇 |
2022年 | 31篇 |
2021年 | 65篇 |
2020年 | 35篇 |
2019年 | 55篇 |
2018年 | 61篇 |
2017年 | 53篇 |
2016年 | 47篇 |
2015年 | 56篇 |
2014年 | 64篇 |
2013年 | 116篇 |
2012年 | 189篇 |
2011年 | 202篇 |
2010年 | 128篇 |
2009年 | 116篇 |
2008年 | 142篇 |
2007年 | 183篇 |
2006年 | 151篇 |
2005年 | 124篇 |
2004年 | 138篇 |
2003年 | 108篇 |
2002年 | 104篇 |
2001年 | 100篇 |
2000年 | 108篇 |
1999年 | 69篇 |
1998年 | 74篇 |
1997年 | 73篇 |
1996年 | 69篇 |
1995年 | 37篇 |
1994年 | 36篇 |
1993年 | 43篇 |
1992年 | 61篇 |
1991年 | 47篇 |
1990年 | 50篇 |
1989年 | 56篇 |
1988年 | 58篇 |
1987年 | 42篇 |
1986年 | 46篇 |
1985年 | 45篇 |
1984年 | 21篇 |
1983年 | 24篇 |
1982年 | 30篇 |
1981年 | 17篇 |
1980年 | 22篇 |
1979年 | 18篇 |
1978年 | 15篇 |
1977年 | 13篇 |
1976年 | 16篇 |
1975年 | 12篇 |
1974年 | 9篇 |
排序方式: 共有3435条查询结果,搜索用时 0 毫秒
91.
92.
Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment 总被引:1,自引:0,他引:1
93.
94.
95.
Background
The chronic disease eosinophilic esophagitis may be mediated by the innate immune system. Activation of toll-like receptors (TLRs) in other tissues is known to initiate eosinophil infiltration, thus TLRs may be a potential mediator of esophageal eosinophilia. Little is known about TLRs in the esophagus. 相似文献96.
97.
Cairns RA Iqbal J Lemonnier F Kucuk C de Leval L Jais JP Parrens M Martin A Xerri L Brousset P Chan LC Chan WC Gaulard P Mak TW 《Blood》2012,119(8):1901-1903
Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) occur in most grade 2 and 3 gliomas, secondary glioblastomas, and a subset of acute myelogenous leukemias but have not been detected in other tumor types. The mutations occur at specific arginine residues and result in the acquisition of a novel enzymatic activity that converts 2-oxoglutarate to D-2-hydroxyglutarate. This study reports IDH1 and IDH2 genotyping results from a set of lymphomas, which included a large set of peripheral T-cell lymphomas. IDH2 mutations were identified in approximately 20% of angioimmunoblastic T-cell lymphomas (AITLs), but not in other peripheral T-cell lymphoma entities. These results were confirmed in an independent set of AITL patients, where the IDH2 mutation rate was approximately 45%. This is the second common genetic lesion identified in AITL after TET2 and extends the number of neoplastic diseases where IDH1 and IDH2 mutations may play a role. 相似文献
98.
Background
The ethnic usage of exotics and indigenous problem plants is a highly debated topic, as legislative requirements over-shadow their potential medicinal value, particularly to treat sexually transmitted infections (STIs). Limited information exists regarding their medicinal value among the Bapedi.Objectives
To ascertain the importance of exotics and indigenous problem plants in the treatment of STIs, a major global primary health care challenge.Methods
A field observation and semi-structured questionnaire focussing on species diversity, types of STIs treated and medicinal preparation as well as application was used to collect data from 34 traditional healers.Results
Seven exotics and three indigenous problem species were identified. These species were used to treat four STIs; with Catharanthus roseus illustrating its dominance in the treatment of gonorrhoea. Some medicinal species used by Bapedi traditional healers have been validated through scientific research or through their extensive use by various cultures in South Africa and other parts of Africa. To the best of our knowledge Alternanthera pungens, Caesalpinia decapetala, Cinnamomum verum, and Citrullus lanatus are reported for the first time in the treatment of the investigated STIs.Conclusions
Exotic and indigenous problem species constitute an important component of the STIs treatment protocol. Their utilization by Bapedi cautions against the narrow-minded approach of indiscriminate eradication, as these species can play a significant role in the primary health care needs of socio-economic vulnerable people. 相似文献99.
Study ObjectivesTo determine the combined effects of aging and propofol on autonomic nervous system activity using heart rate variability (HRV) analysis.DesignProspective, two-parallel group, repeated-measures study.SettingOperating room of an academic hospital.PatientsASA physical status 1, 2, and 3 patients, including 14 young (< 65 yrs) and 14 elderly (> 65 yrs) patients. All patients were scheduled for general surgical procedures with general anesthesia.InterventionsEach patient received two successive propofol doses during induction (0.5 mg/kg and 1.5 mg/kg) with a time interval allowing the return of Bispectral Index (BIS) to awake values.MeasurementsPrimary outcomes were HRV parameters, which included normalized power spectral density at low frequency (LFnorm) and high frequency (HFnorm) bands and the ratio LF/HF. Secondary outcomes were BIS values, blood pressure, heart rate, respiratory rate, and body temperature.Main ResultsThe interaction of age and propofol dose level was significant [multivariate analysis of variance, F (3,74) = 4.72, P = 0.005], representing a combined effect of age and propofol dose level on the mean HRV parameters. Propofol induction decreased the HFnorm component and enhanced LFnorm and LF/HF in the younger group, but had no significant effect in the older group. Such an effect was not associated with a significant difference in systolic blood pressure (SBP) decrements between the younger and older groups. Within each group, propofol caused significant decreases in SBP compared with preinduction values. Heart rate did not change significantly during propofol administration between groups or within groups.ConclusionsPropofol and aging act in synergy to depress the activity of the cardiovascular component of the autonomic nervous system. However, a compensatory increase in sympathetic outflow was seen in young patients. Such counterbalance was not observed in the older group. 相似文献
100.