全文获取类型
收费全文 | 78242篇 |
免费 | 5072篇 |
国内免费 | 151篇 |
专业分类
耳鼻咽喉 | 924篇 |
儿科学 | 2508篇 |
妇产科学 | 2037篇 |
基础医学 | 12132篇 |
口腔科学 | 2319篇 |
临床医学 | 6829篇 |
内科学 | 15908篇 |
皮肤病学 | 1504篇 |
神经病学 | 7647篇 |
特种医学 | 3076篇 |
外国民族医学 | 24篇 |
外科学 | 10831篇 |
综合类 | 305篇 |
现状与发展 | 1篇 |
一般理论 | 66篇 |
预防医学 | 6402篇 |
眼科学 | 1268篇 |
药学 | 4223篇 |
中国医学 | 73篇 |
肿瘤学 | 5388篇 |
出版年
2023年 | 323篇 |
2022年 | 575篇 |
2021年 | 1202篇 |
2020年 | 850篇 |
2019年 | 1193篇 |
2018年 | 1467篇 |
2017年 | 1232篇 |
2016年 | 1524篇 |
2015年 | 1626篇 |
2014年 | 2129篇 |
2013年 | 2794篇 |
2012年 | 4200篇 |
2011年 | 4300篇 |
2010年 | 2333篇 |
2009年 | 2409篇 |
2008年 | 3792篇 |
2007年 | 3986篇 |
2006年 | 3837篇 |
2005年 | 3719篇 |
2004年 | 3158篇 |
2003年 | 3076篇 |
2002年 | 2710篇 |
2001年 | 2564篇 |
2000年 | 2561篇 |
1999年 | 2310篇 |
1998年 | 957篇 |
1997年 | 812篇 |
1996年 | 768篇 |
1995年 | 632篇 |
1994年 | 588篇 |
1993年 | 579篇 |
1992年 | 1523篇 |
1991年 | 1501篇 |
1990年 | 1460篇 |
1989年 | 1294篇 |
1988年 | 1246篇 |
1987年 | 1118篇 |
1986年 | 1104篇 |
1985年 | 1026篇 |
1984年 | 720篇 |
1983年 | 582篇 |
1982年 | 347篇 |
1981年 | 332篇 |
1979年 | 593篇 |
1978年 | 368篇 |
1977年 | 335篇 |
1975年 | 361篇 |
1974年 | 391篇 |
1973年 | 377篇 |
1972年 | 384篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
81.
W. Ziegler D. von Cramon 《European archives of psychiatry and clinical neuroscience》1986,236(1):44-49
Summary This paper deals with a particular aspect of speech motor control in patients suffering from apraxia of speech. Three experiments are reported concerning the phase relations between individual speech gestures. These include the timing of laryngeal, velar and labial movements relative to lingual gestures.A total of 8 patients and 12 normal controls were examined using speech material which was designed according to appropriate phonetic paradigms. Evaluation was performed on the basis of speech signal parameters referring to the kinematics of inter-articulatory phasing. Deviations of the patient group were found in all three experiments. This suggests that disturbed phase relations of individual speech movements are a general feature of apraxic speech. It is further hypothesized that the described motor symptoms are the origin of a variety of phonemic errors. Support for this view is provided by appropriate examples which refer to the examined paradigms. By this argument, much of the disturbed phonemic structure of apraxic speech may be accounted for by timing deficits. 相似文献
82.
Martine C M Willems L W Ernest van Heurn Geert W Schurink Frank M van der Sande Jan H M Tordoir 《Nephrology, dialysis, transplantation》2006,21(12):3583-3584
83.
84.
85.
Emil Maier Alfred Freiherrn von Christiani 《Journal of cancer research and clinical oncology》1940,49(6):679-710
Ohne ZusammenfassungMit 13 Textabbildungen 相似文献
86.
E S C Korf E C W van Straaten F-E de Leeuw W M van der Flier F Barkhof L Pantoni A M Basile D Inzitari T Erkinjuntti L-O Wahlund E Rostrup R Schmidt F Fazekas P Scheltens 《Diabetic medicine》2007,24(2):166-171
HYPOTHESIS: Based on recent findings on the association between vascular risk factors and hippocampal atrophy, we hypothesized that hypertension and diabetes mellitus (DM) are associated with medial temporal lobe atrophy (MTA) in subjects without disability, independent of the severity of white matter hyperintensities. METHODS: In the Leukoaraiosis And DISability in the elderly (LADIS) study, we investigated the relationships between DM, hypertension, blood pressure and MTA in 582 subjects, stratified by white matter hyperintensity severity, using multinomial logistic regression. MTA was visually scored for the left and right medial temporal lobe (score 0-4), and meaned. RESULTS: Mean age was 73.5 years (sd 5.1), 54% was female. Of the subjects, 15% had DM, and 70% had a history of hypertension. The likelihood of having MTA score 3 was significantly higher in subjects with DM (OR 2.9; 95% CI: 1.1-7.8) compared with an MTA score of 0 (no atrophy). The odds ratio for MTA score 2 was not significantly increased (OR 1.8; CI: 0.9-4). Systolic and diastolic blood pressure and a history of hypertension were not associated with MTA. There was no interaction between DM and hypertension. Stratification on white matter hyperintensities (WMH) did not alter the associations. CONCLUSION: Our study strengthens the observation that MTA is associated with DM, independently of the amount of small vessel disease as reflected by WMH. 相似文献
87.
Anneloes Dirks Lucianne Groenink Koen G C Westphal Jocelien D A Olivier P Monika Verdouw Jan van der Gugten Mark A Geyer Berend Olivier 《Neuropsychopharmacology》2003,28(10):1790-1798
Chronically elevated levels of corticotropin-releasing factor (CRF) in transgenic mice overexpressing CRF in the brain (CRF-OE) appear to be associated with alterations commonly associated with major depressive disorder, as well as with sensorimotor gating deficits commonly associated with schizophrenia. In the present study, we tested the hypothesis that antipsychotics may be effective in normalizing prepulse inhibition (PPI) of acoustic startle in CRF-OE mice, which display impaired sensorimotor gating compared to wild-type (WT) mice. The typical antipsychotic haloperidol and atypical antipsychotic risperidone improved PPI in the CRF-OE mice, but were ineffective in WT mice. The atypical antipsychotic clozapine did not influence PPI in CRF-OE mice, but reduced gating in WT mice. This effect of clozapine in the CRF-OE mice may thus be regarded as a relative improvement, consistent with the observed effect of haloperidol and risperidone. As expected, the anxiolytic, nonantipsychotic chlordiazepoxide was devoid of any effect. All four compounds dose-dependently reduced the acoustic startle response irrespective of genotype. These results indicate that antipsychotic drugs are effective in improving startle gating deficits in the CRF-OE mice. Hence, the CRF-OE mouse model may represent an animal model for certain aspects of psychotic depression, and could be a valuable tool for research addressing the impact of chronically elevated levels of CRF on information processing. 相似文献
88.
Dr. P. von Puky 《Archives of orthopaedic and trauma surgery》1939,40(1):14-70
Ohne Zusammenfassung 相似文献
89.
Ohne ZusammenfassungDie vorstehende Arbeit ist im Laboratorium des Herrn Prof. Cyon in der medicinischen Academie in St. Petersburg ausgeführt. 相似文献
90.
Saskia L.M.A. Beeres MD Katja Zeppenfeld MD Jeroen J. Bax MD Petra Dibbets-Schneider Marcel P.M. Stokkel MD Willem E. Fibbe MD Ernst E. van der Wall MD Douwe E. Atsma MD Martin J. Schalij MD 《Heart rhythm》2007,4(3):257-265
BACKGROUND: Bone marrow cell injection has been introduced to treat patients with ischemic heart disease. However, focal application of bone marrow cells may generate an arrhythmogenic substrate. OBJECTIVES: To assess the electrophysiological and arrhythmogenic effects of intramyocardial bone marrow cell injection in patients with chronic myocardial ischemia. METHODS: Bone marrow was aspirated in 20 patients (65+/-11 years, 19 male) with drug-refractory angina and myocardial ischemia. Electroanatomical mapping (NOGA, Biosense-Webster, Waterloo, Belgium) was performed during mononuclear cell isolation. Areas for cell injection were selected based on the localization of ischemia on SPECT. These areas were mapped in detail to evaluate local bipolar electrogram duration, amplitude and fragmentation. Mononuclear cells were injected in the ischemic area with the NOGA system. SPECT and electroanatomical mapping were repeated at 3 months. Holter monitoring was repeated at 3 and 6 months. RESULTS: SPECT revealed a decrease in the number of segments with ischemia (3.5+/-2.5 vs. 1.1+/-1.0 at 3 months; P<0.01) and an increased left ventricular ejection fraction (44+/-13% vs. 49+/-17% at 3 months; P=0.02). The number of ventricular premature beats remained unchanged (10+/-24x10(2)/24h vs. 8+/-23x10(2)/24h at 3 months (P=NS) and 12+/-30x10(2)/24h at 6 months (P=NS)). At 3 months follow-up, bone marrow cell injection did not prolong electrogram duration (15.9+/-4.6 ms vs. 15.6+/-4.0 ms; P=NS), decrease electrogram amplitude (3.8+/-1.5 mV vs. 3.8+/-1.5 mV; P=NS), or increase fragmentation (2.0+/-0.5 vs. 1.9+/-0.4; P=NS). CONCLUSION: Intramyocardial bone marrow cell injection does not increase the incidence of ventricular arrhythmias and does not alter the electrophysiological properties of the injected myocardium. 相似文献