全文获取类型
收费全文 | 899篇 |
免费 | 63篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 15篇 |
妇产科学 | 8篇 |
基础医学 | 141篇 |
口腔科学 | 7篇 |
临床医学 | 92篇 |
内科学 | 188篇 |
皮肤病学 | 29篇 |
神经病学 | 80篇 |
特种医学 | 48篇 |
外科学 | 199篇 |
综合类 | 4篇 |
预防医学 | 32篇 |
眼科学 | 15篇 |
药学 | 48篇 |
肿瘤学 | 46篇 |
出版年
2023年 | 4篇 |
2022年 | 13篇 |
2021年 | 26篇 |
2020年 | 22篇 |
2019年 | 23篇 |
2018年 | 27篇 |
2017年 | 17篇 |
2016年 | 38篇 |
2015年 | 32篇 |
2014年 | 52篇 |
2013年 | 49篇 |
2012年 | 68篇 |
2011年 | 71篇 |
2010年 | 36篇 |
2009年 | 33篇 |
2008年 | 52篇 |
2007年 | 45篇 |
2006年 | 31篇 |
2005年 | 40篇 |
2004年 | 37篇 |
2003年 | 18篇 |
2002年 | 32篇 |
2001年 | 21篇 |
2000年 | 27篇 |
1999年 | 25篇 |
1998年 | 14篇 |
1997年 | 9篇 |
1996年 | 8篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 10篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 7篇 |
1985年 | 2篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1979年 | 2篇 |
1978年 | 7篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 7篇 |
1974年 | 6篇 |
1973年 | 6篇 |
1972年 | 4篇 |
1971年 | 2篇 |
1938年 | 1篇 |
排序方式: 共有964条查询结果,搜索用时 15 毫秒
21.
22.
23.
Badria Al-Ghaithi Rahul Chanchlani Magdalena Riedl Paul Thorner Christoph Licht 《Pediatric nephrology (Berlin, Germany)》2016,31(11):2079-2086
Background
Post-infectious glomerulonephritis (PIGN) usually follows a benign course, but few children have an atypical, severe presentation, and these exceptional cases have been linked to the dysregulation of the complement alternative pathway (CAP). There is a considerable overlap in the histopathological features of PIGN and C3 glomerulopathy (C3G), which is also associated with CAP dysregulation but has a poorer outcome. We hypothesized that PIGN and C3G define a disease spectrum, and that in the past there may be some children with C3G who were misclassified with PIGN before C3G was described as a separate disease entity.Methods
Children with PIGN (n?=?33) diagnosed between 1985 and 2010 who underwent a renal biopsy due to their unusual course were reviewed and of them, 8 were reclassified into C3G based on the current classification criteria. Outcome was based on the degree of proteinuria, C3 level, and renal function at follow-up.Results
Sixteen (72.7%) children with typical PIGN recovered completely as compared to only 2 (25%) with C3G. Of note, children with “typical” PIGN had a more severe disease course at onset; however, the outcome at last follow up was favorable.Conclusions
Our results support the hypothesis that PIGN and C3G form a disease spectrum and have different long-term clinical implications and management strategies.24.
Chantal Loirat Fadi Fakhouri Gema Ariceta Nesrin Besbas Martin Bitzan Anna Bjerre Rosanna Coppo Francesco Emma Sally Johnson Diana Karpman Daniel Landau Craig B Langman Anne-Laure Lapeyraque Christoph Licht Carla Nester Carmine Pecoraro Magdalena Riedl Nicole C. A. J. van de Kar Johan Van de Walle Marina Vivarelli Véronique Frémeaux-Bacchi for HUS International 《Pediatric nephrology (Berlin, Germany)》2016,31(1):15-39
25.
Albertsmeier M. Hofmann A. Baumann P. Riedl S. Reisensohn C. Kewer J. L. Hoelderle J. Shamiyeh A. Klugsberger B. Maier T. D. Schumacher G. Köckerling F. Pession U. Weniger M. Fortelny R. H. 《Hernia》2022,26(1):87-95
Hernia - The short-stitch technique for midline laparotomy closure has been shown to reduce hernia rates, but long stitches remain the standard of care and the effect of the short-stitch technique... 相似文献
26.
Antje Wiesener Karl X. Knaup Maike Büttner‐Herold Anne Dieterle Johanna Stoeckert Bernhard Riedl Christian Morath Alexandra Wald Florian Vondran Felix Braun Johannes Schdel Markus Schueler Mario Schiffer Kerstin Amann Andr Reis Cornelia Kraus Michael S. Wiesener 《American journal of transplantation》2020,20(5):1410-1416
In light of the organ shortage, there is a great responsibility to assess postmortal organs for which procurement has been consented and to increase the life span of transplanted organs. The former responsibility has moved many centers to accept extended criteria organs. The latter responsibility requires an exact diagnosis and, if possible, omission of the harmful influence on the transplant. We report the course of a kidney transplant that showed a steady decline of function over a decade, displaying numerous cysts of different sizes. Clinical workup excluded the most frequent causes of chronic transplant failure. The filed allocation documents mentioned the donor’s disease of oral‐facial‐digital syndrome, a rare ciliopathy, which can also affect the kidney. Molecular diagnosis was performed by culturing donor tubular cells from the recipient´s urine more than 10 years after transplantation. Next‐generation panel sequencing with DNA from tubular urinary cells revealed a novel truncating mutation in OFD1, which sufficiently explains the features of the kidney transplants, also found in the second kidney allograft. Despite this severe donor disease, lifesaving transplantation with good long‐term outcome was enabled for 5 recipients. 相似文献
27.
Hagen Loertzer Tanja Huesch Ruth Kirschner-Hermanns Ralf Anding Armin Rose Bernhard Brehmer Carsten Maik Naumann Fabian Queissert Joanne Nyarangi-Dix Roland Homberg Markus Grabbert Torben Hofmann Tobias Pottek Wilhelm Hübner Axel Haferkamp Ricarda Michaela Bauer Alexander Kretschmer 《Neurourology and urodynamics》2020,39(3):987-993
28.
Thomas Schachtner Maik Stein Natalie M. Otto Petra Reinke 《Transplant international》2020,33(3):288-297
Preformed donor-reactive T cells are relatively resistant to standard immunosuppression and account for an increased incidence of T cell-mediated rejection (TCMR) and inferior kidney allograft outcomes. We analyzed 150 living donor kidney transplant recipients (KTRs) of a first kidney allograft. Ninety-eight ABO-compatible (ABOc) and 52 ABO-incompatible (ABOi) KTRs were included. Samples were collected at 6 time points, before rituximab, before immunoadsorption and pretransplantation, at +1, +2, and +3 months posttransplantation, and donor-reactive T cells were measured by interferon-γ ELISPOT assay. Twenty of 98 ABOc (20%) and 12 of 52 ABOi KTRs (23%) showed positive pretransplant ELISPOT. Eight of 20 ABOc-KTRs (40%) with positive pretransplant ELISPOT showed TCMR, whereas 17 of 78 ABOc-KTRs (22%) with negative pretransplant ELISPOT did (P = 0.148). Seven of 12 ABOi KTRs (57%) with positive pretransplant ELISPOT showed TCMR, whereas only 3 of 40 ABOi KTRs (8%) with negative pretransplant ELISPOT did (P < 0.001). Interestingly, 6 of 7 ABOi KTRs with positive pretransplant ELISPOT that persists after ABO desensitization developed TCMR. Among 118 KTRs with negative pretransplant ELISPOT, 10 of 72 ABOc-KTRs (14%), but 0 of 46 ABOi KTRs, developed positive posttransplant ELISPOT (P = 0.006). Preformed donor-reactive T cells that persist despite ABO desensitization identify KTRs at highest risk of TCMR. Less de-novo donor-reactive T cells after ABO desensitization may account for less TCMR. Both, the use of rituximab and early initiation of calcineurin inhibitor-based maintenance immunosuppression may contribute to these findings. 相似文献
29.
The vascular endothelium is specifically sensitive to oxidative stress, and this is one of the mechanisms that causes widespread endothelial dysfunction in most cardiovascular diseases and disorders. Protection against reactive oxygen species (ROS)-mediated oxidative damage via antioxidant mechanisms is essential for tissue maintenance and shows therapeutic potential for patients suffering from cardiovascular and metabolic disorders. Salvianolic acid B (SalB), a natural bioactive component known from Traditional Chinese Medicine, has been reported to exert cellular protection in various types of cells. However, the underlying mechanisms involved are not fully understood. Here, we showed that SalB significantly promoted the migratory and tube formation abilities of human bone marrow derived-endothelial progenitor cells (BM-EPCs) in vitro, and substantially abrogated hydrogen peroxide (H2O2)-induced cell damage. SalB down-regulated Nox4 and eNOS, as well as nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase expression upon H2O2 induction that in turn prevents oxidative-induced endothelial dysfunction. Moreover, SalB suppressed the Bax/Bcl-xL ratio and caspase-3 activation after H2O2 induction. Furthermore, our results provide mechanistic evidence that activation of the mTOR/p70S6K/4EBP1 pathways is required for both SalB-mediated angiogenic and protective effects against oxidative stress-induced cell injury in BM-EPCs. Suppression of MKK3/6-p38 MAPK-ATF2 and ERK1/2 signaling pathways by SalB significantly protected BM-EPCs against cell injury caused by oxidative stress via reduction of intracellular ROS levels and apoptosis. Taken together, by providing a mechanistic insight into the modulation of redox states in BM-EPCs by SalB, we suggest that SalB has a strong potential of being a new proangiogenic and cytoprotective therapeutic agent with applications in the field of endothelial injury-mediated vascular diseases. 相似文献
30.
Yubo Tang Corina Vater Angela Jacobi Cornelia Liebers Xuenong Zou Maik Stiehler 《British journal of pharmacology》2014,171(9):2440-2456