全文获取类型
收费全文 | 50729篇 |
免费 | 2299篇 |
国内免费 | 111篇 |
专业分类
耳鼻咽喉 | 1184篇 |
儿科学 | 1328篇 |
妇产科学 | 2588篇 |
基础医学 | 7358篇 |
口腔科学 | 1393篇 |
临床医学 | 3336篇 |
内科学 | 9388篇 |
皮肤病学 | 1812篇 |
神经病学 | 4912篇 |
特种医学 | 1236篇 |
外国民族医学 | 2篇 |
外科学 | 6215篇 |
综合类 | 310篇 |
一般理论 | 7篇 |
预防医学 | 3573篇 |
眼科学 | 1528篇 |
药学 | 4692篇 |
中国医学 | 73篇 |
肿瘤学 | 2204篇 |
出版年
2022年 | 410篇 |
2021年 | 804篇 |
2020年 | 439篇 |
2019年 | 661篇 |
2018年 | 1250篇 |
2017年 | 881篇 |
2016年 | 1020篇 |
2015年 | 1096篇 |
2014年 | 1333篇 |
2013年 | 1957篇 |
2012年 | 2908篇 |
2011年 | 3127篇 |
2010年 | 1502篇 |
2009年 | 1069篇 |
2008年 | 2096篇 |
2007年 | 2398篇 |
2006年 | 2460篇 |
2005年 | 2239篇 |
2004年 | 2245篇 |
2003年 | 2108篇 |
2002年 | 1931篇 |
2001年 | 1276篇 |
2000年 | 1234篇 |
1999年 | 1112篇 |
1998年 | 335篇 |
1992年 | 624篇 |
1991年 | 604篇 |
1990年 | 585篇 |
1989年 | 636篇 |
1988年 | 659篇 |
1987年 | 655篇 |
1986年 | 643篇 |
1985年 | 633篇 |
1984年 | 476篇 |
1983年 | 396篇 |
1979年 | 657篇 |
1978年 | 409篇 |
1977年 | 343篇 |
1976年 | 327篇 |
1975年 | 454篇 |
1974年 | 630篇 |
1973年 | 608篇 |
1972年 | 535篇 |
1971年 | 497篇 |
1970年 | 466篇 |
1969年 | 489篇 |
1968年 | 445篇 |
1967年 | 345篇 |
1966年 | 354篇 |
1965年 | 241篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Bień Agnieszka Rzońca Ewa Zarajczyk Marta Wilkosz Katarzyna Wdowiak Artur Iwanowicz-Palus Grażyna 《Quality of life research》2020,29(10):2669-2677
Quality of Life Research - The aim of the study was to assess QoL and identify and analyse its determinants in women with endometriosis. The study was performed in 2019 in health centres in Lublin... 相似文献
2.
3.
Marta Rozanski Valentin Neuhaus Emily Thornton Stéphanie J. E. Becker James P. Rathmell David Ring 《Journal of hand and microsurgery》2015,7(1):30-35
This study used the National Survey of Ambulatory Surgery (NSAS) database to measure the incidence of and risk factors for symptoms in the ambulatory surgery center and problems within 24 h after isolated carpal tunnel release (CTR). The NSAS contained records on 400,000 adult patients with carpal tunnel syndrome who were treated with CTR in 2006, based on ICD-9 codes. The type of anesthesia used and factors associated with symptoms and problems were sought in bivariate and multivariable statistical analyses. The mean duration of the procedure was 16 ± 8.8 min. Only 5 % were performed under local anesthesia without sedation, 45 % with IV sedation, 28 % regional anesthesia, and 19 % general anesthesia. Symptoms in the ambulatory surgery center or a problem within 24 h after discharge were recorded in 10 % of patients, all of them minor and transient, including difficulties with pain and its treatment. The strongest risk factors were male sex, age of 45 years and older, and participation of an anesthesiologist. Local anesthesia and regional anesthesia were associated with more perioperative symptoms and postoperative problems. Most CTR are performed with some sedation in the United States. CTR is a safe procedure: one in 10 patients will experience a minor issue in the perioperative or immediate postoperative period. 相似文献
4.
5.
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep 下载免费PDF全文
Flavio Torres Alejandro González‐Candia Camilo Montt Germán Ebensperger Magdalena Chubretovic María Serón‐Ferré Roberto V. Reyes Aníbal J. Llanos Emilio A. Herrera 《Journal of pineal research》2015,58(3):362-373
Pulmonary hypertension of the newborn (PHN) constitutes a critical condition with severe cardiovascular and neurological consequences. One of its main causes is hypoxia during gestation, and thus, it is a public health concern in populations living above 2500 m. Although some mechanisms are recognized, the pathophysiological facts that lead to PHN are not fully understood, which explains the lack of an effective treatment. Oxidative stress is one of the proposed mechanisms inducing pulmonary vascular dysfunction and PHN. Therefore, we assessed whether melatonin, a potent antioxidant, improves pulmonary vascular function. Twelve newborn sheep were gestated, born, and raised at 3600 meters. At 3 days old, lambs were catheterized and daily cardiovascular measurements were recorded. Lambs were divided into two groups, one received daily vehicle as control and another received daily melatonin (1 mg/kg/d), for 8 days. At 11 days old, lung tissue and small pulmonary arteries (SPA) were collected. Melatonin decreased pulmonary pressure and resistance for the first 3 days of treatment. Further, melatonin significantly improved the vasodilator function of SPA, enhancing the endothelial‐ and muscular‐dependent pathways. This was associated with an enhanced nitric oxide‐dependent and nitric oxide independent vasodilator components and with increased nitric oxide bioavailability in lung tissue. Further, melatonin reduced the pulmonary oxidative stress markers and increased enzymatic and nonenzymatic antioxidant capacity. Finally, these effects were associated with an increase of lumen diameter and a mild decrease in the wall of the pulmonary arteries. These outcomes support the use of melatonin as an adjuvant in the treatment for PHN. 相似文献
6.
More than just crushing: a prospective pre‐post intervention study to reduce drug preparation errors in patients with feeding tubes 下载免费PDF全文
7.
Inflammation but not obesity or insulin resistance is associated with increased plasma fibroblast growth factor 23 concentration in the elderly 下载免费PDF全文
8.
9.
L. Misery E. Weisshaar E. Brenaut A.W.M. Evers F. Huet S. Ständer A. Reich E. Berardesca E. Serra-Baldrich J. Wallengren D. Linder J.W. Fluhr J.C. Szepietowski H. Maibach for the Special Interest Group on sensitive skin of the International Forum for the Study of Itch 《Journal of the European Academy of Dermatology and Venereology》2020,34(2):222-229
The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of sensitive skin. Sensitive skin is not an immunological disorder but is related to alterations of the skin nervous system. Skin barrier abnormalities are frequently associated, but there is no cause and direct relationship. Further studies are needed to better understand the pathophysiology of sensitive skin – as well as the inducing factors. Avoidance of possible triggering factors and the use of well-tolerated cosmetics, especially those containing inhibitors of unpleasant sensations, might be suggested for patients with sensitive skin. The role of psychosocial factors, such as stress or negative expectations, might be relevant for subgroups of patients. To date, there is no clinical trial supporting the use of topical or systemic drugs in sensitive skin. The published data are not sufficient to reach a consensus on sensitive skin management. In general, patients with sensitive skin require a personalized approach, taking into account various biomedical, neural and psychosocial factors affecting sensitive skin. 相似文献