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101.
Stiers P Vanderkelen R Vanneste G Coene S De Rammelaere M Vandenbussche E 《Developmental medicine and child neurology》2002,44(6):370-382
Several studies have tried to establish the prevalence of visual-perceptual impairment in children with physical disabilities, particularly in those with cerebral palsy (CP), but failed to take into account the selective impairment of non-verbal intelligence that is frequent in these children. This has resulted in the confounding of visual-perceptual and non-verbal intelligence impairment. In the present study we aimed to determine how widespread visual-perceptual impairment is in children with CP by evaluating perceptual ability together with the performance level on non-verbal intelligence subtests. All children (n=96; 44 females, 52 males) who attended an institute for children with physical disabilities were included (age ranged from 4 years 11 months to 21 years 5 months) who had a non-verbal mental age between 3 and 7 years; Total IQ was <85 in 91% of participants. They were given a grating acuity task and the visual-perceptual battery L94, comprising six visual object recognition and two visuoconstruction tasks. Relative to their performance level on non-verbal intelligence subtests, 37.5% of the children were impaired on at least one task, and 18.7% on two or more tasks. No child was impaired on the visuoconstruction tasks. Visual-perceptual impairment was highest among six children with brain malformation (67%), followed by spastic CP (40%), and brain damage acquired after the first year of life (38%). There was no difference in visual-perceptual impairment between the subtypes of spastic CP. Results are not secondary to visual acuity deficits, as only one L94 task was significantly correlated with acuity impairment. We conclude that visual-perceptual impairment is frequent in children with physical disabilities, and not restricted to children with CP of hypoxic-ischaemic origin. 相似文献
102.
Recently, thoracoscopic approaches to the spine have taken on greater clinical applications in the treatment of spinal deformity with generally good results. However, the steep learning curve must be ascended by the surgeon and may lead to complications early in one's experience. There also exists a learning curve for the anesthesiologist to become adept at obtaining single lung ventilation and managing this throughout the operative procedure. We report a case of an 11-year-old patient with severe scoliosis who developed air in both chest cavities, mediastinum, peritoneum, retroperitoneum, and subcutaneous tissue after intubation with a double-lumen endotracheal tube. The patient remained hemodynamically stable throughout this period, and bilateral chest tubes were placed. The patient remained on the ventilator for 24 hours and was extubated without sequelae. Complications from a thoracoscopic approach to the spine for deformity are most often attributed to the learning curve of the surgeon; however, the entire operative team becomes exposed to the challenges of performing this procedure. This report documents a life-threatening complication of air throughout the chest, mediastinum, abdomen, and subcutaneous tissues in a patient with severe scoliosis. 相似文献
103.
Priscila J.S. Pires Rita Mattiello Magali S. Lumertz Thiago P. Morsch Simone C. Fagondes Magda L. Nunes David Gozal Renato T. Stein 《Jornal de pediatria》2019,95(2):231-237
Objective
To validate the Pediatric Obstructive Sleep Apnea Screening tool for use in Brazil.Materials and methods
The Brazilian version of this questionnaire, originally validated and tested in the United States, was developed as follows: (a) translation; (b) back-translation; (c) completion of the final version; (d) pre-testing. The questionnaire was applied prior to polysomnography to children aged 3–9 years from October 2015 to October 2016, and its psychometric properties (i.e., validity and reliability) were evaluated. The accuracy was assessed from comparisons between polysomnographic results and corresponding questionnaire scores.Results
Sixty patients were enrolled, and based on polysomnographic findings, 48% patients had normal apnea-hypopnea index, while the remaining 52% met the criteria for obstructive sleep apnea. Minimum O2 saturation level was significantly lower among obstructive sleep apnea children (p = 0.021). Satisfactory concordance was found between individual apnea-hypopnea index and questionnaire scores. Bland–Altman plot-derived bias was 0.1 for the difference between measures, with 5.34 (95% CI: 4.14–6.55) and ?5.19 (95%CI: ?6.39 to ?3.98) for the upper and lower agreement range. Internal consistency derived from Cronbach's alpha was 0.84 (95%CI: 0.78–0.90).Conclusion
The questionnaire was translated to and validated into Brazilian-Portuguese version, and showed good reliability and concordance with apnea-hypopnea index. This questionnaire offers a reliable screening option for sleep-disordered breathing in children. 相似文献104.
Objectives
To describe the association between sleep duration and weight–height development in children and adolescents.Source of data
A non-systematic search in the MEDLINE database was performed using the terms anthropometry, body composition, overweight, obesity, body mass index, growth, length, short stature, sleep, children, and infants and adolescents, limited to the last 5 years. The references cited in the revised articles were also reviewed, when relevant.Synthesis of data
Sleep disorders are prevalent in the pediatric population. Among them, insomnia, which leads to a reduction in total sleep time, is the most prevalent disorder. Evidence found in the current literature allows the conclusion that sleep time reduction has a role in the current pandemic of overweight and obesity. Studies associating sleep deprivation and deficit in height growth are still insufficient.Conclusions
The association between shorter sleep duration and risk of overweight and obesity is well established for all pediatric age groups. However, more evidence is needed to establish an association between insufficient sleep duration and height growth deficit. Pediatricians should include the encouragement of healthy sleep habits in their routine guidelines as an adjuvant in the prevention and management of excess weight. 相似文献105.
Highly purified individual chains of normal fibrinogen and fibrinogen Cleveland I were prepared by chromatographing the reduced, carboxymethylated whole protein upon columns of S-P Sephadex C-50. This method is suitable, as a preliminary step, in the further study of either normal or abnormal fibrinogen. 相似文献
106.
Jack Spira Francis Wiener Magda Babonits Jenny Gamble Jacques Miller George Klein 《International journal of cancer. Journal international du cancer》1981,28(6):785-798
G-banding analysis was carried out on a series of hybrids derived from the fusion of a chromosome 15-trisomic murine T-cell leukemia of AKR origin and normal diploid fibroblasts or lymphocytes of the CBT6T6 strain. Due to the 14; 15 translocation involved in the generation of the T6 marker, the chromosomes No. 15 and 14 derived from the normal and the tumor parent can be distinguished cytogenetically. Highly tumorigenic, in vitro maintained hybrids, and high-tumorigenic segregants of originally low-tumorigenic in vitro hybrids, selected by in vivo passage, showed a similar cytogenetic pattern. It was characterized by the amplification of the tumor-derived chromosomes No. 15 from the expected 3 to 5.5 ± 0.2 copies and a concomitant decrease of the normal derived T(14;15)6 from 2 copies to 0.9 ± 0.2. All other autosomes except No. 14 showed only minor random variations, around the expected number of 4 copies. The tumor-derived chromosome 14 was amplified from the expected 2 to 3 copies. The lowtumorigenic hybrids showed the opposite pattern with a decrease in the number of the tumor-derived 15 chromosome from 3 to 2.6 ± 0.1 and the maintenance of the two normal parent derived T(14;15)6 chromosomes. These findings suggest the existence of a qualitative difference between the 15 chromosomes derived from the tumor vs. the normal parent, due to mutation or proviral DNA insertion in the tumor-derived homologue. Amplification of the changed locus and a decrease in the dosage of its normal counterpart appear to favor tumorigenicity. 相似文献
107.
108.
R. J. Gilbert Antonnette A. Wieneke Janice Lanser Magda ?imkovi?ová 《Epidemiology and infection》1972,70(4):755-762
Two methods are described for the extraction of enterotoxin from foods incriminated in incidents of staphylococcal food poisoning. Enterotoxin was detected serologically in 12 of 24 food samples from 20 separate incidents: eight samples contained enterotoxin A, three contained D and one both A and B. The amount of enterotoxin in nine foods, based on 100% recovery, varied from 0·02 to 0·09 μg./g. 相似文献
109.
Hipwell AE White HR Loeber R Stouthamer-Loeber M Chung T Sembower MA 《Journal of studies on alcohol》2005,66(5):630-639
OBJECTIVE: In recent years, rates of alcohol use among young female adolescents have been increasing. Despite such trends, little is known about the precursors of use and intentions to use alcohol among preadolescents. The current prospective study examines the prevalence and correlates of alcohol use, future intentions and alcohol-related expectancies among young girls from ages 8 to 10 years. METHOD: Alcohol use behaviors and attitudes were assessed annually over a 3-year period in a community sample of 1,161 preadolescent girls. The girls comprised the two oldest cohorts of the ongoing Pittsburgh Girls Study (N = 2,451). Data were collected via separate parent and child interviews conducted in the participants' homes. RESULTS: The prevalence of alcohol use without parental permission was less than 3% in any given year between ages 8 and 10. Most girls reported sipping only, and there was little continuity of use across assessments. Alcohol-related expectancies were predominantly negative during this period but decreased with age. Positive expectancies, however, increased, particularly among white girls. Early alcohol use was predicted by black race and peer use. Intentions to use alcohol were predicted by low levels of negative expectancies and peer use. CONCLUSIONS: This study adds to the knowledge of use of alcohol and the development of positive and negative alcohol-related expectancies in girls of elementary school age. 相似文献
110.