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排序方式: 共有670条查询结果,搜索用时 31 毫秒
661.
Chang SM Hahm BJ Lee JY Shin MS Jeon HJ Hong JP Lee HB Lee DW Cho MJ 《Journal of affective disorders》2008,106(1-2):159-167
BACKGROUND: According to published reports, the prevalence rates of major depressive disorder (MDD) in East-Asian countries are lower than in the West, but the reasons for this difference have not been fully investigated. METHODS: This study compared the Korean Epidemiologic Catchment Area study (KECAS) sample with the National Comorbidity Survey (NCS, USA) sample. In total, this study included 5349 participants in KECAS and 7423 in NCS aged 18-54 years. The Composite International Diagnostic Interview (CIDI) assessed for MDD. Analysis of the individual symptoms of MDD was completed. RESULTS: Diagnostic threshold of MDD was higher in KECAS participants than in NCS participants. Koreans diagnosed with MDD showed more work impairment than Americans with MDD. Koreans were more likely to express the symptoms like "low energy" and "concentration difficulty," but less to the symptoms like "depressed mood" and "thoughts of death" during an episode of MDD. LIMITATIONS: The Diagnostic and Statistical Manual of Mental Disorders (DSM) framework was the basis for the majority of the comparisons made in this study. Various depressive symptoms not included in the DSM framework were unlikely to be detected. CONCLUSIONS: Cross-cultural differences in rates of MDD are attributable to diagnostic thresholds. Symptom patterns and forms of depression in Korea, as defined by the DSM framework, are not identical to those in the U.S. 相似文献
662.
Chang SM Cho SJ Jeon HJ Hahm BJ Lee HJ Park JI Cho MJ 《Journal of Korean medical science》2008,23(2):167-175
This study estimates the treated prevalence of schizophrenia and the annual costs associated with the illness in Korea in 2005, from a societal perspective. Annual direct healthcare costs associated with schizophrenia were estimated from National Health Insurance and Medical Aid records. Annual direct non-healthcare costs were estimated for incarceration, transport, community mental health centers, and institutions related to schizophrenia. Annual indirect costs were estimated for the following components of productivity loss due to illness: unemployment, reduced productivity, premature mortality, and caregivers' productivity loss using a human capital approach based on market wages. All costs were adjusted to 2005 levels using the healthcare component of the Consumer Price Index. The treated prevalence of schizophrenia in 2005 was 0.4% of the Korean population. The overall cost of schizophrenia was estimated to be $ 3,174.8 million (3,251.0 billion Won), which included a direct healthcare cost of $ 418.7 million (428.6 billion Won). Total direct non-healthcare costs were estimated to be $ 121 million (123.9 billion Won), and total indirect costs were estimated at $ 2,635.1 million (2,698.3 billion Won). Unemployment was identified as the largest component of overall cost. These findings demonstrate that schizophrenia is not rare, and that represents a substantial economic burden. 相似文献
663.
Moon JH Kwak SS Park G Jung HY Yoon BS Park J Ryu KS Choi SC Maeng I Kim B Jun EK Kim S Kim A Oh S Kim H Kim KD You S 《Stem cells and development》2008,17(4):713-724
In this study, we report the isolation and characterization of a population of multipotent keloid-derived mesenchymal-like stem cells (KMLSCs) from keloid scalp tissues. These KMLSCs expressed the typical mesenchymal stem cell marker proteins CD13, CD29, CD44, CD90, fibronectin, and vimentin when they were cultured in serum-containing medium and when subsequent exposure to various differentiation media resulted in their differentiation into adipocytes, osteoblasts, chondrocytes, smooth muscle cells, and angiogenic endothelial cells. When KMLSCs were cultured in neural stem culture conditions (i.e., in the presence of epidermal growth factor and fibroblast growth factor 2 in substrate-free conditions), they produced large numbers of neurospheres containing nestin-, CD133-, and SOX2-positive cells that expressed neural-crest stem cell markers. Subsequent exposure of these cells to different differentiation conditions resulted in cells that expressed neuronal cell-, astrocyte-, oligodendrocyte-, or Schwann cell-specific markers. Our study suggests that KMLSCs may be an alternative adult stem cell resource for regenerative tissue repair and auto-transplantation. 相似文献
664.
665.
Rui Zhang Kyoung Ah Kang Mei Jing Piao Weon Young Chang Young Hee Maeng Sungwook Chae In Kyung Lee Bum Joon Kim Jin Won Hyun 《Food and chemical toxicology》2010
This study investigated the cytoprotective effect of butin, a flavonoid, on hydrogen peroxide (H2O2)-induced mitochondrial dysfunction. Electron spin resonance (ESR) spectrometry revealed butin’s significant scavenging effects on superoxide radicals and hydroxyl radicals. When H2O2 was used to induce an increase in mitochondrial reactive oxygen species (ROS) in Chinese hamster lung fibroblast (V79-4) cells, butin treatment decreased high level of ROS. Butin also attenuated intracellular Ca2+ levels that have been induced by H2O2. Furthermore, butin recovered ATP levels and succinate dehydrogenase activity that had been decreased by H2O2 treatment. We conclude these results suggest butin decreased mitochondrial ROS accumulation, balanced intracellular Ca2+ levels, and improved mitochondrial energy production, thus recovering mitochondrial function. 相似文献
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668.
研究纳入丹麦1997~2006年间107806例起始胰岛素促泌剂或二甲双胍单药治疗的2型糖尿病患者(年龄>20岁,没有使用过胰岛素单药和联合治疗)其中9607例患者既往存在心肌梗死史.随访时间3.3年,每3个月为一个区间,收集不同胰岛素促泌剂或二甲双胍的处方,如果某区间无处方量则以之前最多3个处方量的区间
作为参考. 相似文献
669.
Niya Mileva MD Hirofumi Ohashi MD PhD Pasquale Paolisso MD Jonathon Leipsic MD PhD Takuya Mizukami MD PhD Jeroen Sonck MD PhD Bjarne L. Norgaard MD PhD Hiromasa Otake MD PhD Brian Ko MD PhD Michael Maeng MD PhD Daniel Munhoz MD PhD Sakura Nagumo MD PhD Marta Belmonte MD Dobrin Vassilev MD PhD Daniele Andreini MD PhD Emanuele Barbato MD PhD Bon-Kwon Koo MD PhD Bernard De Bruyne MD PhD Carlos Collet MD PhD 《Catheterization and cardiovascular interventions》2023,101(7):1182-1192
670.
Lars Jakobsen MD PhD Evald H. Christiansen MD PhD Phillip Freeman MD PhD Johnny Kahlert PhD Karsten Veien MD Michael Maeng MD PhD Bent Raungaard MD PhD Julia Ellert MD PhD Steen D. Kristensen MD DMSci Martin K. Christensen MD Christian J. Terkelsen MD DMSci Troels Thim MD PhD Ashkan Eftekhari MD PhD Rebekka V. Jensen MD PhD Nicolaj B. Støttrup MD PhD Anders Junker MD PhD Henrik S. Hansen MD DMSci Lisette O. Jensen MD DMSci 《Catheterization and cardiovascular interventions》2023,101(1):13-21