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81.
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ObjectiveTo investigate the anti-inflammatory activity of the extract of Vernonia amygdalina (V.A).MethodsInflammatory response was induced by topical application of croton oil dissolved in suitable vehicle on the rat ear. After 6 hrs, cutting out the ear quantitated the response. The cut ear was weighed and the increase in weight relative to control group was evaluated.ResultsWhen co-applied with croton oil to the rat ear extract of V.A. produced a reduction in the inflammatory response when croton oil alone was applied to the rat ear. The extract produced (69.1±2.0)% reduction of the inflammatory response produced by croton oil alone, lower than the reduction of the inflammatory response produced by acetyl salicylic acid [(71.1±2.0)%].ConclusionsThis finding suggests that extract of V.A. exhibits anti-inflammatory activity and may explain the usefulness of the leaves of this plant in the treatment of inflammatory disease conditions by traditional healers. 相似文献
83.
OA Georgewill UO Georgewill RNP Nwankwoala 《Asian Pacific journal of tropical medicine》2010,3(2):133-135
ObjectiveTo investigate the acute and delayed anti-inflammatory effects of Morning oleifera lam (MOL) crude methanolic extract.MethodsCompared the anti-inflammatory effects of MOL with that of standard anti-inflammatory agents like indomethacin and hydrocortisone using Air Pouch Model.ResultsIn both acute and delayed inflammation, the MOL extract produced dose dependent anti-inflammatory effect [acute IC50= (399.30 ±5.43) mg/kg; delayed IC50= (510.26±4.53) mg/kg]. The order of anti-inflammatory potency for the three drugs was hydrocortisone> indomethacin > MOL.ConclusionsThese observations indicate that MOL possesses potential anti-inflammatory property. 相似文献
84.
Wnt10b inhibits obesity in ob/ob and agouti mice 总被引:4,自引:0,他引:4
Wright WS Longo KA Dolinsky VW Gerin I Kang S Bennett CN Chiang SH Prestwich TC Gress C Burant CF Susulic VS MacDougald OA 《Diabetes》2007,56(2):295-303
The Wnt family of secreted signaling molecules has profound effects on diverse developmental processes, including the fate of mesenchymal progenitors. While activation of Wnt signaling blocks adipogenesis, inhibition of endogenous Wnt/beta-catenin signaling by Wnt10b promotes spontaneous preadipocyte differentiation. Transgenic mice with expression of Wnt10b from the FABP4 promoter (FABP4-Wnt10b) have less adipose tissue when maintained on a normal chow diet and are resistant to diet-induced obesity. Here we demonstrate that FABP4-Wnt10b mice largely avert weight gain and metabolic abnormalities associated with genetic obesity. FABP4-Wnt10b mice do not gain significant body weight on the ob/ob background, and at 8 weeks of age, they have an approximately 70% reduction in visceral and subcutaneous adipose tissues compared with ob/ob mice. Similarly, on the lethal yellow agouti (A(y)) background, FABP4-Wnt10b mice have 50-70% less adipose tissue weight and circulating leptin at 5 months of age. Wnt10b-Ay mice are more glucose tolerant and insulin sensitive than A(y) controls, perhaps due to reduced expression and circulation of resistin. Reduced expression of inflammatory cytokines may also contribute to improved glucose homeostasis. 相似文献
85.
Background
Spontaneous uterine rupture is a life threatening obstetrical emergency encountered infrequently in the emergency department. Its diagnosis is often missed or delayed, leading to maternal and fetal mortality.Method
We present a case of ruptured uterus diagnosed by ultrasound in a 33-year-old gravid female with two previous cesarean sections.Objective
To show the role of ultrasound in uterine ruptureResult
Ultrasound demonstrates uterine laceration and intra-abdominal dislocation of placenta and foetusConclusion
Because of the severity of the complication and the great variation of symptoms in connection with it, the authors encourage the use of ultrasound screening in the detection of this rare, but often catastrophic complication. 相似文献86.
87.
88.
de Leon-Casasola OA 《Current review of pain》1999,3(3):173-177
Pain due to cancer is frequently visceral, and neurolysis of the sympathetic axis has been shown to be an effective and safe method for treating this visceral pain. Several studies have documented the efficacy of neurolytic blocks both by a reduction in the intensity of pain and by a decrease in opioid consumption. Neurolysis of the sympathetic axis should be incorporated into the pain specialist's arsenal as an adjuvant to oral pharmacologic therapy. 相似文献
89.
Torrance GW Raynauld JP Walker V Goldsmith CH Bellamy N Band PA Schultz M Tugwell P;Canadian Knee OA Study Group 《Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society》2002,10(7):518-527
OBJECTIVE: Viscosupplementation with hylan G-F 20 has recently become registered for treatment of patients with osteoarthritis (OA) of the knee in most parts of the world. The cost effectiveness and cost utility of this new therapeutic modality were determined as part of a Canadian prospective, randomized, 1-year, open-label, multicentered trial. DESIGN: A total of 255 patients were randomized to 'Appropriate care with hylan G-F 20' (AC+H) or 'Appropriate care without hylan G-F 20' (AC). Costs (1999 Canadian dollars) were collected from the societal viewpoint and included all costs related to OA of the knee and OA in all joints. Patients completed a number of outcomes questionnaires including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Health Utilities Index Mark 3 (HUI3). Data were collected at clinic visits (baseline, 12 months) and by telephone (1, 2, 4, 6, 8, 10, and 12 months). RESULTS: The AC+H group over the year had higher costs ($2125-$1415=$710, P< 0.05), more patients improved (69%-40%=29%,P =0.0001), greater increases in HUI3 (0.13-0.03=0.10, P< 0.0001) and increased quality-adjusted life years (QALYs) (0.071, P< 0.05). The incremental cost-effectiveness ratio was $2505/patient improved. The incremental cost-utility ratio was $10000/QALY gained. Sensitivity analyses and a second cost perspective gave similar results. CONCLUSION: The cost-utility ratio is below the suggested Canadian adoption threshold. The results provide strong evidence for adoption of treatment with hylan G-F 20 in the patients and settings studied in the trial. 相似文献
90.
OA Ogunbiyi MB BS FMCA KG Branch FRCA 《International journal of clinical practice》1999,53(2):154-155
We present a case of unanticipated postoperative apnoea in a patient with associated medical illness to illustrate the diagnostic difficulty that can arise in the detection and subsequent management of mivacurium apnoea. A high index of suspicion is essential in the presence of concomitant medical conditions that may cause prolonged apnoea. To our knowledge, no report exists documenting the unanticipated occurrence of mivacurium apnoea in a patient with previously undiagnosed pseudoCholinesterase deficiency and concomitant medical illness who has previously undergone ‘balanced’ general anaesthesia. 相似文献