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Christian Geroin PhD Carlo Alberto Artusi MD PhD Jorik Nonnekes MD PhD Camila Aquino MD PhD Divyani Garg MD DM DNB MNAMS Marian L. Dale MD MRC Darbe Schlosser Yijie Lai MD Mohammad Al-Wardat PT PhD Mehri Salari MD PhD Robin Wolke MD Valery Tsinda Labou PhD Gabriele Imbalzano MD Serena Camozzi PT Marcelo Merello MD PhD Bastiaan R. Bloem MD PhD Tamine Capato PhD Ruth Djaldetti MD Karen Doherty MD FRCP Alfonso Fasano MD PhD Houyam Tibar MD Leonardo Lopiano MD PhD Nils G. Margraf MD PhD Caroline Moreau MD PhD Yoshikazu Ugawa MD PhD Roongroj Bhidayasiri MD FRCP Michele Tinazzi MD PhD the International Parkinson Movement Disorders Society Task Force on Postural Abnormalities 《Movement disorders》2023,38(5):732-739
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Ruchi Gupta M.D. Ram Krishan Gautam M.D. D.V.D. MNAMS Taru Dewan M.D. Minakshi Bhardwaj M.D. 《Pediatric dermatology》2014,31(1):e31-e32
Langerhans cell disease (LCD) occurring as an isolated tumor of the eyelids has been described infrequently. Moreover, none of the reported cases had associated systemic involvement. We present an unusual case of LCD of the eyelids masquerading as blepharochalasis with central diabetes insipidus (CDI). 相似文献
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Multicentric epithelioid angiosarcoma of the spine: a case report of a rare bone tumor 总被引:1,自引:0,他引:1
Anwar Marthya MBBS D-Orth MS Gopinathan Patinharayil MBBS D-Orth MS DNB MNAMS Kishore Puthezeth MBBS Sreeja Sreedharan MBBS MD Ajaya Kumar MBBS MD DNB Chathoth Meethal Kumaran MBBS D-Orth MS 《The spine journal》2007,7(6):716-719
BACKGROUND CONTEXT: Epithelioid angiosarcoma (EA) is a high-grade sarcoma of vascular origin. EA is a rare variant of angiosarcoma. It is characterized by large cells with an epethelioid morphology. EA has been reported in sites like skin thyroid, adrenal gland, soft tissue, and rarely in bone. PURPOSE: The current article describes a case of multicentric EA of the spine that presented simultaneously at T4 spine and the posterior one third of the left fourth rib. STUDY DESIGN/SETTINGS: This study included a patient with a rare spinal tumor, which presented insidiously. Radiologically, the lesions were osteolytic with erosion of cortices. The tumor was composed of nests and cords of malignant cells with epithelioid morphology with areas of vascular differentiation, necrosis, and hemorrhage. Anastomosing vascular spaces lined by epithelioid endothelial cells suggested focal endotheliod differentiation. METHODS: Histopathological evaluation of the tumor obtained from en bloc resection of the fourth rib and specimen from decompression of the fourth thoracic vertebra was done. Immunohistochemistry showed positivity for endothelioid cell markers like CD31 and factor VIII related antigen. The authors point out the need for immunohistochemical evaluation after careful histological analysis for vascular differentiation for an accurate diagnosis of vascular bone tumors with epithelioid features so that an erroneous diagnosis of metastatic carcinoma can be avoided. EA occurs rarely in bone. EA is marked by the presence of large polygonal epithelioid malignant cells with marked cellular atypia and pleomorphism. The arrangement of the cells may mimic epithelial neoplasm. These types of lesions are a definite diagnostic challenge in bone biopsy. The tumor was treated with en bloc resection of the rib and decompression of the body of T4 spine, followed by megavoltage radiotherapy. Follow-up X-rays showed regression of the tumor at 2 years. CD31 is the most sensitive marker for EA. Even in the absence of obvious vascular differentiation, abundant intratumoral hemorrhage and intratumoral neutrophils are definite morphologic changes that should suggest a vascular origin. RESULTS: The patient was followed up for 2 years. A conservative surgical approach with a radical course of megavoltage radiotherapy could yield a good result in EA of bone. At the time of writing this report, there is no evidence of tumor recurrence. CONCLUSION: It is important to differentiate EA from other tumors because the clinical course and treatment are specific for these conditions. Careful histologic and immunohistochemical analysis will clinch the diagnosis. Even though rare, we stress the importance to be aware of the existence of this tumor, which is essential for correct diagnosis. 相似文献
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Role of oxidative stress in melasma: a prospective study on serum and blood markers of oxidative stress in melasma patients 下载免费PDF全文
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Jaipur block in postherpetic neuralgia 总被引:3,自引:0,他引:3
Rishi Bhargava MD . MNAMS . MSSVD Sudha Bhargava MD Kailash N. Haldia MD Puneet Bhargava . MBBS 《International journal of dermatology》1998,37(6):465-468
Background Postherpetic neuralgia, a common sequele to herpes zoster infection, is a chronic debilitating problem. The available therapeutic modalities are usually ineffective. Methods A total of 3960 patients (1326 women and 2634 men; age group, 21–84 years), with postherpetic neuralgia as the presenting complaint and with pain lasting from 2 months to 5 years, were treated with Jaipur block, consisting of local subcutaneous infiltration of 2% xylocaine, 0.5% bupivacaine, and 4 mg/mL dexamethasone solution. Patients were followed up at six-weekly intervals with subsequent injections given in non-responders. Results Twenty eight per cent of patients obtained complete relief from pain after a single injection, another 57% after a second injection, and 11% after a third injection; 4% of patients did not respond to treatment. The non-responders were either old (over 60 years) or had pain lasting for more than 2 years. The response to therapy was similar in both sexes. There were 31 left-handed patients in this study. Pain was less severe in left-handed patients and they obtained complete relief after a single injection. Side-effects including giddiness and sweating were seen, occasionally, in a few patients. Conclusions Ninety six per cent of patients obtained complete relief after the block with a follow-up of up to 19 years. 相似文献