食管鳞癌遗传易感性与基质金属蛋白酶-1基因多态性的关系

目的 探讨基质金属蛋白酶-1(MMP-1)基因多态性与食管鳞癌发病风险的关系.方法 运用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析方法检测450对病例与对照中MMP-1的1G/2G基因多态性.结果 与1G等位基因携带者(包括1G/1G及1G/2G基因型)比较,2G/2G基因型携带者与食管鳞癌显著相关[OR=1.39;95%可信区间(CI):1.06～1.81].此外,食管鳞癌的发病风险在吸炳者及女性中更加显著,其OR及95%CI分别为1.59(1.09～2.31)及1.76(1.05～2.97).结论 MMP-1基因多态性可能在食管鳞癌的发生过程中起到一定作用.

Abstract：

Objective Our study aimed to test the association between the matrix metalloproteinase-1 ( MMP-1) polymorphism and risk of esophageal squamous cell carcinoma ( ESCC ) . Methods We determined the MMP-1 polymorphism in 450 ESCC cases and 450 frequency-matched controls by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Results We found evidence for a significant association between the 2G/2G genotype and ESCC risk compared with 1G allele,including 1G/1G genotype and 1G/2G genotype [OR = 1. 39;95% confidence interval (CI), 1. 06-1. 81].Furthermore,the increased risk was found to be in smokers (OR,1. 59;95% CI, 1. 09-2. 31) and in female (OR, 1.76;95% CI, 1.05-2. 97). Conclusion Our study suggests that the MMP-1 promoter polymorphism may play a role in the etiology of ESCC.     

The Evaluation of Relevant Factors Influencing Skin Graft Changes in Color Over Time

BACKGROUND Objective studies evaluating the relevant factors that affect skin graft changes in color over time have yet to be published.
OBJECTIVE Therefore, the patterns of the grafted skin's color changes and the presence of relevant factors were analyzed statistically.
MATERIALS AND METHODS The study included 107 skin grafts in 107 subjects. Using a chromameter, the colors of skin graft, the area adjacent to the recipient site, and the donor site were measured. The grafted skin's color changes and the color difference were analyzed with respect to several factors.
RESULTS Over time, the grafted skin became lighter, redness decreased, yellowness increased, and the color difference decreased. As the donor site was lighter, the grafted skin was lighter and less red. The grafted skin was lighter in females than in males. The skin graft type was not related to the lightness and the redness. The grafted skin was lightest in the upper arm and darkest in the lower leg. The grafted skin was lighter in Fitzpatrick Skin Type III, followed by Type IV and then Type V.
CONCLUSION The factors that affected the skin graft's lightness were time, the lightness of the donor, sex, the hand, the foot, and Fitzpatrick skin type.     

百香果对酒精中毒小鼠的解酒作用及其护肝作用的研究

目的：探讨百香果提取物对酒精中毒小鼠的解酒作用以及对酒精性肝损伤的护肝作用。方法：将小鼠随机分为空白对照组,模型对照组,阳性（联苯双酯）对照组（150 mg·kg^-1）,百香果乙酸乙酯提取物低（15 mg·kg^-1）、中（30 mg·kg^-1）、高剂量组（60 mg·kg^-1）,按照相应的剂量灌胃,空白对照组和模型对照组给予相同体积的生理盐水。（1）1 h后,给予50%乙醇（6 g·kg^-1）,建立中毒模型。记录小鼠的醉酒时间与醒酒时间,并做统计学分析。（2）连续灌胃7 d,在末次给药后,除空白对照组给予生理盐水外,其余各组每隔8小时50%乙醇灌胃（6 g·kg^-1）1次,建立急性肝损伤模型。在末次乙醇灌胃1 h后,取血,解剖取肝脏,利用试剂盒测定血清和肝匀浆的生化指标。并将肝脏组织做组织病理学检查。结果：百香果乙酸乙酯提取物对酒精中毒的小鼠有解酒作用;与模型对照组相比,百香果乙酸乙酯提取物可以降低急性肝损伤体内谷丙转氨酶（ALT）、谷草转氨酶（AST）的活性,增高肝匀浆中过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、谷胱甘肽（GSH）的活性及其含量,降低肝匀浆中丙二醇（MDA）、甘油三酯（TG）的含量。肝脏病理结果显示,百香果乙酸乙酯提取物有一定的护肝作用。结论：百香果乙酸乙酯提取物对乙醇中毒的小鼠有一定的解酒作用,并且对酒精性肝损伤有一定的预防肝损伤的作用。     

Pneumoencephalography in Early Infancy –Risks, Clinical Indications and Technical Considerations

Summary
In a series of 123 encephalographic examinations performed on infants and children during the years 1951–56, serious reactions were found only in the youngest age group, four out of six being less than one year old. The probable causes of these reactions are discussed. From the experience gained in this series the clinical indications and a scheme of techniques for encephalographic examination in different cases and age groups are outlined.     

汽车司机职业紧张因素聚类分析研究

目的:探讨汽车司机的职业紧张因素.方法:聚类分析.结果:汽车司机职业紧张因素可分为社会支持、负性状态、工作要求、工作控制、紧张程度和忙碌单调6大类.结论:应采取综合措施减少职业紧张.     

Chronic necrotizing pulmonary aspergillosis in a patient treated with a tumor necrosis factor‐α inhibitor

Tumor necrosis factor (TNF)‐α is a pro‐inflammatory cytokine that plays an important role in the pathogenesis of a variety of autoimmune diseases. TNF‐α inhibitors have been shown to offer clinical benefits in the treatment of autoimmune and inflammatory disorders, including rheumatoid arthritis, ankylosing spondylitis (AS), and Crohn’s disease. Occasionally, these agents have been associated with infectious complications because of their immunosuppressive activity. Globally, several cases of infections associated with TNF‐α inhibitors have been reported. However, Aspergillus infection associated with etanercept is very rare. We report a case of chronic necrotizing pulmonary aspergillosis in a 51‐year‐old man with AS that developed after treatment with etanercept.     

不同的孕期体重管理模式对妊娠结局影响的临床研究

目的:分析不同体重管理模式对妊娠结局的影响,为孕期保健提供依据。方法:对2009年3月以来门诊就医的1640例孕妇分为按体重增幅管理组716例(A组)和按体重指数管理组924组(B组),前瞻性研究两组体重管理模式对妊娠结局的影响。结果:两组孕妇在年龄、孕前体重、孕次、身高及产检次数上差异均无统计学意义(P>0.05)。两组早产发生率A组为10.20%,B组为6.49%,差异有统计学意义(P<0.01);足月低体重儿A组为4.61%,B组发生率为1.30%,差异有统计学意义(P<0.05);糖代谢异常率A组为17.32%,B组为13.10%,差异有统计学意义(P<0.01);两组巨大儿发生率A组为5.59%,B组为3.90%,差异有统计学意义(P<0.05);两组产后抑郁症A组为9.22%,B组为5.19%,差异有统计学意义(P<0.01);两组妊娠期高血压疾病、产后出血发生率的差异均无统计学意义(P>0.05)。结论:与按体重增幅管理相比,按体重指数管理可以减少早产、足月低体重儿、巨大儿、糖代谢异常和产后抑郁的发生。     

沙利度胺治疗急性白血病的临床疗效及抗血管形成的观察

目的:观察沙利度胺联合化疗治疗急性白血病临床疗效及对血浆血管内皮生长因子(VEGF)、血管内皮生长因子受体(VEGFR)、碱性成纤维细胞生长因子(bFGF)、骨髓微血管密度(MVD)的影响.方法:急性白血病36 例,分为实验组及对照组各18 例.每组均常规化疗,实验组同时口服沙利度胺100 mg/d.治疗前及治疗后8 周采集外周血双抗体夹心酶联免疫吸附法(ELISA)检测血浆VEGF、VEGFR、bFGF 及MVD 测定.结果:实验组与对照组治疗的有效率分别为88.9%(16/18)、77.8%(14/18),差异有统计学意义(P ＜ 0.05).实验组与对照组治疗后血浆VEGF、VEGFR、MVD [(211.74 ± 36.72)pg /mL vs.(288.02 ± 31.77)pg /mL;[(1 359.71 ±390.24)pg/mL vs.(1 753.89 ± 337.04)pg/mL;(8.30 ± 4.57)n/HP vs.(14.78 ± 2.76)n/HP]相比差异有统计学意义(均P ＜ 0.05),血浆[bFGF(2.09 ± 0.17)ng/mL vs.(2.11 ± 0.31)ng/mL]相比差异无统计学意义(P ＞ 0.05).结论:沙利度胺联合化疗可提高急性白血病的缓解率,可能通过抑制血浆VEGF 及其受体表达、减少MVD而发挥抗白血病作用.     

Radiofrequency and 585-nm Pulsed Dye Laser Treatment of Striae Distensae: A Report of 37 Asian Patients

BACKGROUND: Various lasers have recently been reported as effective treatment modalities for striae distensae, but pigmentary alterations are a major concern to the darker skin type. The Thermage (Therma Cool TC; Thermage Inc, Hayward, CA) is a radiofrequency device for the lifting of face and neck, and there is no report of using it for striae distensae. OBJECTIVE: The purpose was to evaluate the effectiveness of the Thermage in combination with pulsed dye laser. MATERIALS AND METHODS: Thirty-seven patients with abdominal striae distensae were treated with the Thermage and 585-nm pulsed dye laser in the first session at baseline. An additional two sessions of pulsed dye laser were performed at Weeks 4 and 8. Thermage was used at fluences of 53 to 97 J/cm2 and pulsed dye laser at fluences of 3.0 J/cm2 with 10-mm spot. Skin biopsies were taken of nine patients. RESULTS: In the subjective assessment, 89.2% of the patients showed "good and very good" to overall improvement, and 59.4% were graded as "good and very good" in elasticity. All of the nine specimens showed an increase in the amount of collagen fibers, and increased elastic fibers were found in six specimens. CONCLUSION: The Thermage and pulsed dye laser appear to be an effective treatment for striae distansae.