A criterion for the selection of artificial posterior teeth

Mandibular movement and masticatory performance were evaluated in the edentulous patients with an experimental denture using posterior artificial teeth of different occlusal schemes in order to determine the criterion for the selection of posterior artificial teeth. Lower masticatory performance was observed with non-anatomic posterior teeth than with semi-anatomic or anatomic ones regardless of the condition of residual ridge and inclination of the horizontal condylar guidance. The value of the lateral component of the masticatory cycle was closely related to the inclination of the cusp and the value of masticatory performance. This suggested strongly that the component could be a criteria for the selection of the type of the artificial posterior teeth.     

Papillary cystadenocarcinoma of the prostate

A giant cystic formation was found behind the prostate of a 69-year-old man who presented with urinary retention. Ultrasonography, computed tomography scans and magnetic resonance imaging revealed a large cystic intrapelvic mass and biopsy of the cyst wall diagnosed papillary cyst adenocarcinoma. Immunohistochemically, the tumor originated from the prostate.     

Establishment of Two Ph1 Chromosome-Positive Cell Lines, KPB-M8 and KPB-M15

Two new Philadelphia (Ph¹) chromosome-positive cell lines, designatedKPB-M8 and KPB-M 15, were established from the peripheral bloodof two patients with chronic myelogenous leukemia in blasticcrisis. Both cell lines were characterized by blastic appearance,the presence of acid phosphatase activity, Fc-receptor, andC₃. and reactivity to monoclonal antibodies such as OKM1, MCS2,MY906, MY4 and MY7. These results indicate that KPB-M8 and KPB-M15cells are of an undifferentiated blast nature. Both cells retainedPh¹ chromosome, and showed numerical and structural changesupon chromosomal analysis. These cell lines should provide auseful source for studying differentiation of hemopoietic cells.     

Attenuation of Non‐neuronal Adenosin Triphosphate Release from Human Bladder Mucosa by Antimuscarinic Agents

Objectives: To clarify the contribution of mucosal muscarinic receptors to bladder function, we investigated the effects of various antimuscarinic drugs on stretch‐induced non‐neuronal adenosin triphosphate (ATP) release in human bladder. Methods: Human bladders were obtained from 17 patients. Bladder strips with and without mucosa were suspended in organ baths. A microdialysis probe was inserted into the strip, Ringer's solution was perfused into the probe, and dialysate was collected under tetrodotoxin pretreatment. The amount of ATP released in dialysate was measured by luciferin‐luciferase assay. The effects of various antimuscarinic drugs on non‐neuronal ATP release were evaluated. Results: Non‐neuronal ATP release from bladder strips without mucosa was approximately 10% of that from strips with mucosa. Non‐neuronal ATP release was significantly inhibited by pretreatment with nifedipine or in Ca²⁺‐free medium. Both methoctramine (M₂ receptor selective antagonist) and 4‐diphenyl‐acetoxy‐N‐methylpiperidine methiodide (4‐DAMP [M₃ receptor selective antagonist]) significantly inhibited release. However, M₁ receptor selective antagonist (pirenzepine) did not have a significant effect on release. Oxybutynin, propiverine, tolterodine and solifenacin caused concentration‐dependent inhibition in non‐neuronal ATP release. The rank order of the maximum inhibition rate was propiverine ≥ solifenacin ≥ tolterodine ≥ oxybutynin. Solifenacin showed an inhibitory effect at a lower concentration compared to other drugs. Conclusion: The data suggest that human bladder mucosa is a main source of stretch‐induced non‐neuronal ATP release, and that stimulation of M₂ and M₃ receptor subtypes of mucosa partly contributes to non‐neuronal ATP release. Various antimuscarinic drugs used for the treatment of overactive bladder may have different inhibitory effects on non‐neuronal ATP release.     

Tetracycline and niacinamide control bullous pemphigoid but not pemphigus foliaceus when these conditions coexist

Pemphigus and pemphigoid are different types of autoimmune bullous disease and can occur in the same patient. We report a female patient with this condition. At first, we diagnosed her with bullous pemphigoid, and we treated her with tetracycline, niacinamide and a topical steroid. Tense bullas disappeared shortly after that, but crusted erythemas mainly on her head and trunk persisted. We examined BP180 and desmoglein 1 enzyme‐linked immunosorbent assays, and also histological features, which showed coexistence of bullous pemphigoid and pemphigus foliaceus concurrently. Therefore, we tried prednisolone, which could control both conditions. This case showed that tetracycline and niacinamide could control bullous pemphigoid, but could not control pemphigus foliaceus, and that prednisolone was effective for both conditions.     

细脚拟青霉多糖I的化学结构

目的　研究细脚拟青霉多糖 的分离纯化方法、相对分子量、单糖组成及其结合方式。方法　室温下水提取出粗多糖 ,采用 Sephadex G- 10 0柱层析纯化。经过酸全水解 ,利用阴离子交换柱测定单糖的组成。甲基化分析测定单糖的结合方式。IR以及 NMR光谱的研究确定糖苷键的类型。结果　经高效液相色谱检测为均一性组成 ,从以后的 GC- MS及 NMR图谱也获得证明。结论　细脚拟青霉多糖 为α- (1→ 6 )连结的葡聚糖 ,相对分子量为 2 .0 5×10 4u。     

Outcomes of Ablation of Paroxysmal Atrial Fibrillation in Patients on Chronic Hemodialysis

AF Ablation in HD Patients . Introduction: It is not common for patients on chronic hemodialysis (HD) to undergo catheter ablation of atrial fibrillation (AF). We aimed to show the outcomes of AF ablation in the HD patients. Methods and Results: Thirty HD patients who underwent pulmonary vein (PV) isolation for drug refractory paroxysmal AF were retrospectively studied, and their AF recurrence free rate and frequency of periprocedural complications were compared to 60 age‐ and gender‐matched control patients not requiring HD. A nonirrigated ablation catheter was used in both patient groups. During a mean follow‐up period of 821 ± 218 days, 16 (54%) of the HD patients remained free from AF recurrence without any antiarrhythmic agents versus 47 (78%) of the control patients with an initial ablation (P = 0.013). A second ablation procedure was performed in 12 patients with an AF recurrence, and consequently 20 (67%) of the HD patients were in sinus rhythm compared to 53 (88%) of the controls during a follow‐up duration of 747 ± 221 after the last ablation (P = 0.012). Bleeding from the venipuncture site requiring a prolonged hospital stay was identified in 2 HD patients and 1 control subject, while no life‐threatening complications were observed in either patient group. Conclusion: Although the success rate of the PV isolation in HD patients was far from satisfactory, it may be considered as one of the therapeutic options for them. (J Cardiovasc Electrophysiol, Vol. 23, pp. 1289‐1294, December 2012)