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排序方式: 共有238条查询结果,搜索用时 15 毫秒
231.
MAKOTO HASEGAWA YOZO SAITO FUJI NAKA† MASAYOSHI KIYOI† 《Clinical and experimental allergy》1983,13(3):277-286
Seasonal variations of total blood histamine were examined in twenty patients with seasonal allergic rhinitis (Japanese cedar pollinosis). In blood specimens taken in the pollen season of 1978, the symptom-free season of 1978. and the pollen season of 1979, the mean values of blood histamine were 61.6, 50.0 and 84.2 ng/ml respectively. The differences in blood histamine levels between the pollen season of 1978 and the symptom-free season of 1978 and between the symptom-free season of 1978 and the pollen season of 1979 were statistically significant. In the symptom-free season of 1978, the blood histamine levels of twenty normal subjects were also examined: the mean value was 58.2 ng/ml. The blood histamine levels of the patients in the symptom-free season were not statistically different from those of the normal subjects. 相似文献
232.
KANAI KOICHI; KAMIYA NAOKI; KAKO MAKOTO; NAKAJIMA TAKEYUKI; FUNAKI HARUO; INOUE NOBORU 《Japanese journal of clinical oncology》1979,9(1):139-143
A gradual increase in serum alpha-fetoprotein (AFP) had beenobserved in a patient with liver cirrhosis and the complicationof rectal carcinoma was disclosed 18 months later. The concentrationof serum AFP decreased rapidly after removal of the tumor andreached a normal value within a month. The level of serum AFP has remained normal and the patient hasbeen well since the operation. There has been no clinical evidenceof the existence of a liver tumor and the production of AFPby the rectal carcinoma cells was suggested. 相似文献
233.
SHIGEYASU SATO HIDEHARU KANZAKI MASUMI YOSHIDA MAKOTO TOKUSHIGE HUEI-SHENG WANG MASATOSHI KARIYA NORIHIKO OKAMOTO YOSHITAKA KARIYA ATSUSHI UCHIDA SHINPEI KASAKURA TAKAHIDE MORI 《American journal of reproductive immunology (New York, N.Y. : 1989)》1990,24(3):67-72
ABSTRACT: T-lineage cells in human decidua of early pregnancies were tested for surface markers, proliferative response, interleukin-2 (IL-2) production, and natural killer (NK) activity. T-lineage (CD2+) cells that were obtained from decidua by the use of E-rosette formation contained fewer CD3+ mature T cells and CD4+ cells than those from the peripheral blood of the same donors, while no differences were seen in the frequencies of CD8+ cells. P55 molecules of IL-2 receptor (IL-2R/p55, Tac antigen) were hardly detected on fresh decidual T-lineage cells, though approximately 20% were positive for HLA-DR. More than a half of decidual T-lineage cells expressed CD56 molecules on their surface and killed K562 cells, the prototype target of NK cells, while most of them were negative for CD16 and CD57. Upon stimulation with IL-2, decidual T-lineage cells demonstrated dose-dependent proliferative response. In addition, they were induced to produce high amounts of IL-2 by stimulation with mitogens but not with alloantigens. These results suggest that human decidua contains high numbers of CD2+3-CD16+56+ lymphocytes and that this population responds to IL-2, produces IL-2 and mediates NK activity. 相似文献
234.
TAKAKAZU HIGUCHI KAZUHIKO NOMOTO HIRAKU MORI HARUO NIIKURA MITSUHIRO OMINE KAZUHIKO SEKIYAMA MAKOTO YOSHIBA RIKIYA FUJITA 《Journal of gastroenterology and hepatology》1997,12(3):237-242
We report on a case of primary hepatic lymphoma that developed in a patient with chronic hepatitis C. Given that Japan is an area endemic for both hepatitis B and C viruses, we reviewed 51 Japanese cases of primary hepatic lymphoma, addressing the question as to whether the Japanese cases have unique characteristics and whether there is a causal relationship to the presence of chronic liver disease. Primary hepatic lymphoma most commonly affected middle-aged males. Presenting symptoms and physical findings were non-specific. Aminotransferases tended to stay in the low range compared with marked increases in lactate dehydrogenase. Sixteen patients (31%) had chronic liver disease, eight had liver cirrhosis and eight had chronic hepatitis, suggesting that there is a possible aetiological link between chronic liver disease and primary hepatic lymphoma. 相似文献
235.
SHIGERU OMI HIROAKI OKAMOTO FUMIO TSUDA MAKOTO MAYUMI 《Journal of gastroenterology and hepatology》1990,5(6):646-652
A plasma pool from 12 asymptomatic carriers seropositive for antibody against hepatitis B e antigen (anti-HBe) contained hepatitis B virus (HBV) with chimpanzee infectious doses of 1-100/mL, and another pool from 12 carriers positive for hepatitis B e antigen (HBeAg) contained 10(8)/mL doses or more. The HBeAg-positive pool contained 10(6)-fold more HBV DNA than the anti-HBe-positive pool, reflecting the difference in infectivity in chimpanzees. The precore region sequences of HBV DNA in the two plasma pools were amplified by polymerase chain reaction, and separate HBV DNA clones were propagated for determining the nucleotide sequence. Of 114 clones from the anti-HBe-positive pool, 113 displayed a point mutation from guanine to adenine at nucleotide 83 in the precore region, which converted codon 28 for tryptophan (TGG) to a stop codon (TAG), and the remaining clone had a point mutation from adenine to cytosine at the first letter of codon 1 (CTG) to inhibit the translation initiation of the precore region. Precore region defects, in contrast, were observed in only 10 (8%) of 119 clones from the HBeAg-positive pool. These results indicate the infectious capacity of HBV mutants, defective in the precore region and incapable of directing the synthesis and secretion of HBeAg, which prevail in the circulation of hosts after they seroconvert from HBeAg to anti-HBe. 相似文献
236.
TAKASHI ASHIHARA M.D. TAKENORI YAO M.D. TSUNETOYO NAMBA M.D. Ph .D. MAKOTO ITO M.D. Ph .D. TAKANORI IKEDA M.D. Ph .D. AYAKA KAWASE M.D. SUNAO TODA M.D. TORU SUZUKI MASASHI INAGAKI M.D. MASARU SUGIMACHI M.D. Ph .D. MASAHIKO KINOSHITA M.D. Ph .D. KAZUO NAKAZAWA Ph .D. 《Journal of cardiovascular electrophysiology》2001,12(12):1393-1403
INTRODUCTION: It is known that high-strength shock disrupts the lipid matrix of the myocardial cell membrane and forms reversible aqueous pores across the membrane. This process is known as "electroporation." However, it remains unclear whether electroporation contributes to the mechanism of ventricular defibrillation. The aim of this computer simulation study was to examine the possible role of electroporation in the success of defibrillation shock. METHODS AND RESULTS: Using a modified Luo-Rudy-1 model, we simulated two-dimensional myocardial tissue with a homogeneous bidomain nature and unequal anisotropy ratios. Spiral waves were induced by the S1-S2 method. Next, monophasic defibrillation shocks were delivered externally via two line electrodes. For nonelectroporating tissue, termination of ongoing fibrillation succeeded; however, new spiral waves were initiated, even with high-strength shock (24 V/cm). For electroporating tissue, high-strength shock (24 V/cm) was sufficient to extinguish ongoing fibrillation and did not initiate any new spiral waves. Weak shock (16 to 20 V/cm) also extinguished ongoing fibrillation; however, in contrast to the high-strength shock, new spiral waves were initiated. Success in defibrillation depended on the occurrence of electroporation-mediated anodal-break excitation from the physical anode and the virtual anode. Some excitation wavefronts following electrical shock used a deexcited area with recovered excitability as a pass-through point; therefore, electroporation-mediated anodal-break excitation is necessary to block out the pass-through point, resulting in successful defibrillation. CONCLUSION: The electroporation-mediated anodal-break excitation mechanism may play an important role in electrical defibrillation. 相似文献
237.
YOSHIKAZU GOTO TADAAKI ABE SATOSHI SEKINE KEITAROU IIJIMA KATSUYUKI KONDOH MAKOTO MATSUKAWA 《Pacing and clinical electrophysiology : PACE》1998,21(5):1170-1171
This article describes the case of a 71 -year-old woman in whom a permanent pacemaker implantation was performed through an iliac vein because of superior vena cava obstruction after aortic valve reoperation. During a 6-month follow-up, the patient did well and the pacemaker performance was satisfactory. 相似文献
238.
KATSUMI Torigoe OSAMU Numata TAKASHI Sato CHIHAYA Imai KAZUO Takeuchi HAJIME Yamazaki HIROMITSU Hotta NAOKI Boku SATOSHI Yazaki SHYOJI Sudo ATSUSHI Kuwabara SATOSHI Hasegawa & MAKOTO HIURA HARUYOSHI Ino 《Pediatrics international》1999,41(3):285-291
BACKGROUND: Central catecholamines, particularly dopaminergic and noradrenergic systems, have affected the appetitive behavior in patients with anorexia nervosa (AN). The purpose of this study is to distinguish the characteristics of contingent negative variation (CNV) and postimperative negative variation (PINV), which may reflect the level of catecholamine in children with AN. METHODS: Eight children with AN aged 10 to 15 years and 23 age-matched healthy children were recruited. Contingent negative variation was recorded from the frontal midline (Fz), central midline (Cz) and parietal midline (Pz) referenced to linked earlobes during 30 trials consisting of a warning stimulus and an imperative stimulus with an interstimulus interval of 2 s and an intertrial interval of 10 s. The imperative stimulus of each trial required a button press. RESULTS: Children with AN had a diminished amplitude of the CNV. They had a significantly more attenuated early CNV and late CNV amplitude at Cz than normal children. No significant differences were observed between AN children and normal children in the amplitude of PINV at all three electrode sites. No difference could be found between the two groups in the frequencies of normal and abnormal duration of PINV. CONCLUSION: These findings suggest that early CNV may be diminished by norepinephrine deficiency and late CNV may be attenuated by dopaminergic deficiency in children with AN. Reduced CNV may represent impaired cognitive processes which reflect impaired appetitive behavior in AN children. 相似文献