全文获取类型
收费全文 | 232篇 |
免费 | 6篇 |
专业分类
儿科学 | 51篇 |
基础医学 | 12篇 |
口腔科学 | 1篇 |
临床医学 | 20篇 |
内科学 | 45篇 |
皮肤病学 | 5篇 |
神经病学 | 20篇 |
外科学 | 47篇 |
预防医学 | 3篇 |
眼科学 | 1篇 |
药学 | 20篇 |
肿瘤学 | 13篇 |
出版年
2016年 | 4篇 |
2015年 | 3篇 |
2014年 | 2篇 |
2013年 | 1篇 |
2012年 | 1篇 |
2011年 | 1篇 |
2010年 | 2篇 |
2008年 | 1篇 |
2007年 | 5篇 |
2006年 | 13篇 |
2005年 | 9篇 |
2004年 | 15篇 |
2003年 | 9篇 |
2002年 | 5篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1999年 | 13篇 |
1998年 | 23篇 |
1997年 | 19篇 |
1996年 | 17篇 |
1995年 | 18篇 |
1994年 | 12篇 |
1993年 | 13篇 |
1992年 | 6篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1979年 | 6篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有238条查询结果,搜索用时 15 毫秒
11.
HIROSHI OZASA SHIGEYUKI ECHIGO CHUZO MORI TETSURO KAMIYA SHIGETO FUSE KENJI KUROE KOJI KIMURA MAKOTO TAKAMIYA KANJI INOUE 《Pediatrics international》1993,35(6):518-524
Although percutaneous transluminal balloon aortic valvuloplasty (PTAV) has been performed for congenital aortic stenosis in infants and children for several years, its efficacy and the associated aortic regurgitation (AR) have not been widely discussed. Percutaneous transluminal balloon aortic valvuloplasty using an Inoue balloon catheter was performed for congenital aortic stenosis in 12 patients (4–16 years old) in this study. The systolic aortic valve pressure gradient ranged from 42 to 111 mmHg before PTAV and became < 50 mmHg immediately after PTAV in 10 cases (83%). Eight of these 10 patients had no increase in the gradient during subsequent observation for a period of 9–40 months. Aortic regurgitation increased immediately after PTAV in nine cases (75%). It increased from grade 1 to grade 2 in eight cases and from grade 1 to grade 3 in one patient; no significant enlargement of the left ventricular end-diastolic diameter and no significant change in the left ventricular end-diastolic pressure (LVEDP) or the cardiac index was observed during follow-up in these patients. There was a correlation between the diameter of the balloon and efficacy; an appropriate diameter was considered to be about 90% of the aortic annular diameter. Changes in the hemodynamic parameter after PTAV with an Inoue balloon were small in most patients and this procedure is considered to be a treatment that should be attempted prior to surgery for congenital aortic stenosis. 相似文献
12.
SHINTARO OKADA YOSHIKI SEINO HIROKO KODAMA TORU YUTAKA KOJI INUI MAKOTO ISHIDA HYAKUJI YABUUCHI YUTAKA SEINO 《Acta paediatrica (Oslo, Norway : 1992)》1979,68(5):735-738
ABSTRACT. Okada, S., Seino, V., Kodama, H., Yutaka, T., Inui, K., Ishida, M., Yabuuchi, H. and Seino, Y. (Department of Pediatrics, Osaka University Hospital, Fukushima-ku, Osaka and The Third Division, Department of Medicine, University of Kobe, Kobe, Japan). Insulin and glucagon secretion in hepatic glycogenoses. Acta Paediatr Scand 68: 735, 1979.—Insulin and glucagon secretion was investigated in ten patients with hepatic glycogenosis, types I and III, in order to understand the relationship between hypoglycemia and pancreatic function. In all patients, both oral glucose tolerance and intravenous arginine infusion tests revealed hypoinsulinemia. Decreased urinary C-peptide levels with standard food intake also supported hypofunction of pancreatic beta cells. On the contrary, the normal secretion pattern of glucagon in both types indicated in the arginine loading test, intact alpha cells in the pancreas. Persistent hypoinsulinism, which is apparently an adaptation to hypoglycemia, could be an important cause of nutritional dwarfism in both types of glycogenosis. The usefulness of the measurement of urinary C-peptide, which evaluates the pancreatic function and provides management for normal body growth, is discussed. 相似文献
13.
MANABU OGISO MAKOTO TAKEHANA SHIZUKO KOBAYASHI MOTONORI HOSHI 《Experimental eye research》1998,66(6):765-773
Monkey and human lenses contain essentially the same glycosphingolipids, and Lewisxand sialylated Lewisxepitopes are expressed on the terminal structure of neolactotetraosylceramide. However, monolayer cultures of lens epithelial cells from rhesus monkey expressed gangliosides GM3, GD3 and a small amount of GM1, but not sialylated Lewisxepitopes. Eight-week-old cultures on various extracellular matrices resulted in morphological changes in lens epithelial cells. Monolayer of cells cultured on vitronectin or polylysine assembled into aggregates after 4 weeks of culture. Cells cultured on vitronectin expressed sialyl-Lewisxgangliosides and did not exhibit GD3. On collagens, fibronectin and laminin elongated cells were observed in cells cultured for 8 weeks. Thus, the interaction between cells and extracellular matrices influenced morphology and glycosphingolipid composition in lens epithelial cells. 相似文献
14.
KOBAYASHI MAKOTO; MATSUOKA TOMOKO; TAGUCHI HIROKUNI; MORIKI TOSHIAKI; ENZAN HIDEAKI; HARA HIROSHI; MIYOSHI ISAO 《Japanese journal of clinical oncology》1986,16(2):167-174
A 30-year-old previously healthy housewife presented with bilateralpulmonary infiltrates. She was treated with various antibioticsbut died with disseminated intravascular coagulation. Culturesof tracheal aspirates obtained prior to her death yielded Trichosporonbeigelii. Postmortem examination revealed T. beigelii pneumoniawith fungal dissemination in other organs. In addition, manyorgans were found to be infiltrated with atypical mononuclearcells which exhibited cytochemical properties of histiocytes.It was considered, therefore, that T. beigelii pneumonia developedon the basis of underlying malignant histiocytosis. T. beigeliiin her lung sections was fluorescently stained with rabbit antiserumto the fungus isolated from the patient. This is the first reportof Trichosporon beigelii pneumonia associated with malignanthistiocytosis. 相似文献
15.
Antigenicity of eggs (oncospheres), cysticercoids and adults (with immature segments only) of the bile duct tapeworm Hymenolepsis microstoma was analysed using immunoblotting techniques and indirect immunofluorescent antibody (IFA) techniques with immune sera of BALB/c mice (i) infected with different doses of cysticercoids, (ii) during patent or prepatent infection with the lumen phase of the parasite or (iii) sensitized with live or dead eggs. Antibody responses detected by IFA test and immunoblotting showed that antigenicity of eggs (oncospheres) differed from that of cysticercoids and adults. Single worm infections were sufficient to stimulate antibody responses. Mice which had patent infection showed strong antibody responses to all three (egg (oncosphere), cysticercoid, adult) antigens, while mice given two prepatent infections showed some antibody responses to cysticercoid and adult antigens only. Although the normal intermediate hosts of this parasite are arthropods, antibodies to some major egg (oncosphere) antigens were produced in mice given eggs of this parasite orally, either through inoculation of eggs or ingestion of faeces contaminated with eggs. Antibodies were not produced in mice dosed with non-viable eggs. The results are consistent with the hypothesis that cestode parasites express phase- (or stage-) specific antigens. 相似文献
16.
YASUKO SUZUKI SHOKO FUJIMORI MAKOTO SAKAI SHIN-ICHIRO OHKAWA KEIJI UEDA 《Pacing and clinical electrophysiology : PACE》1988,11(3):326-330
A pacemaker lead fracture in the left subclavian vein was caused by compression of the clavicle and the first rib; subsequent coil elongation at the same site on the right side was observed in the replacement lead in a patient with thoracic outlet syndrome. Venography showed narrowing of the subclavian vein at the site where the lead abnormalities were observed. This case illustrates that a lead in the subclavian vein can be easily damaged when a patient has thoracic outlet syndrome. 相似文献
17.
MASAOMI CHINUSHI YOSHIFUSA AIZAWA HIROHIKO KUWANO HIROYUKI HOSONO HITOSHI KITAZAWA YORIKO KUSANO NAOKI NAITHO MAKOTO TAMURA AKIRA SHIBATA 《Pacing and clinical electrophysiology : PACE》1992,15(10):1460-1466
We performed radiofrequency current catheter ablation in two patients with nonischemic sustained ventricular tachycardia (VT). In one patient, two morphologically distinct VTs were induced by electrical stimulation. One showed right bundle branch block pattern and the other left bundle branch block pattern. The earliest site of activation during each VT was determined at the septum of the right ventricle. However, these two sites were close to the His-bundle elecfrogram recording area. In the other patient, a VT with a left bundle branch block pattern occurred spontaneously after the administration of isoproterenol. The earliest site of activation during VT was determined at the outflow tract of the right ventricle. During tachycardia, radiofrequency current ablation (40 W ± 30 sec) was delivered to the earliest site of activation, A few seconds after fulguration, each VT was terminated and additional radio-frequency currents were given near these sites. After the ablation, VT could not be induced by the electrical stimulations, nor did it recur. No side effects were observed and the atrioventricular conduction remained intact. We feel that nonischemic VTs could possibly be treated by using radiofrequency current catheter ablation. 相似文献
18.
An ECG Index of P‐Wave Force Predicts the Recurrence of Atrial Fibrillation after Pulmonary Vein Isolation 下载免费PDF全文
YASUNORI KANZAKI M.D. YASUYA INDEN M.D. Ph.D. MONAMI ANDO M.D. YOSUKE KAMIKUBO M.D. TADAHIRO ITO M.D. YOSHIAKI MIZUTANI M.D. HIROYUKI KATO M.D. AYA FUJII M.D. SATOSHI YANAGISAWA M.D. MAKOTO HIRAI M.D. Ph.D. TOYOAKI MUROHARA M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2016,39(11):1191-1197
19.
HIROKI OKAMOTO KIMIHIRO INOUE TOSHIAKI KAMISAKI KAZUYOSHI TAKAHASHI MAKOTO SATO 《The Journal of pharmacy and pharmacology》1997,49(10):981-984
The effect of the Ca2+-channel antagonist nicardipine on the basal tone of six segments (duodenum, jejunum, ileum, proximal colon, distal colon and rectum) of the guinea-pig intestine has been investigated in muscle preparations. Nicardipine reduced the basal tone of the proximal and distal colon but not of the duodenum, jejunum, ileum and rectum. Similarly, when each segment was incubated in Ca2+-free medium, the basal tone of the proximal and distal colon, but not that of the other four segments, was reduced. The reduced basal tone recovered after cumulative addition of Ca2+ in both colon preparations. The basal tone of the distal colon was partly reduced by tetrodotoxin, atropine and clonidine. Conversely, l -typeCa2+-channel antagonists (Cd2+, verapamil and nicardipine), but not the T-type Ca2+-channel antagonist Ni2+, completely reduced the basal tone of the distal colon. These results indicate that in the regulation of basal tone there are additional regional differences in the effect of Ca2+ influx into the cells from the extracellular fluid which might involve l -type-like Ca2+ channels and might partly be because of neuronal factors. 相似文献
20.
MAKOTO HONDA md EINOSUKE KOGA md TOHRU ISHIKAWA TOSHINORI KOBAYASHI md AKIRA SAWA md YASURO TAKAHASHI md YUTAKA HONDA md 《Psychiatry and clinical neurosciences》1997,51(6):387-392
Abstract Four all-night polysomnograms of a 39-year-old male patient with non-24 h sleep-wake syndrome were recorded. We analysed electroencephalograms (EEG) with the power spectrum method and the wave pattern recognition analysis of Fujimori. The EEC of the rest waking condition showed normal patterns. High-voltage diffuse alpha band waves were observed in sleep stages 2, 3 and 4. The integrated area of the alpha band waves in the analysis epochs showed a strong positive correlation to the delta hand components in the power spectrum of the same epoch during sleep (correlation coefficients r = 0.762–0.815). Alpha hand waves during sleep were clearly different from the alpha waves in the rest waking condition, with respect to slower peak frequency and the frontal dominant voltage distribution. 相似文献