全文获取类型
收费全文 | 499篇 |
免费 | 35篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 15篇 |
妇产科学 | 37篇 |
基础医学 | 73篇 |
口腔科学 | 1篇 |
临床医学 | 28篇 |
内科学 | 131篇 |
皮肤病学 | 9篇 |
神经病学 | 43篇 |
特种医学 | 10篇 |
外科学 | 70篇 |
预防医学 | 41篇 |
眼科学 | 13篇 |
药学 | 27篇 |
中国医学 | 1篇 |
肿瘤学 | 30篇 |
出版年
2022年 | 5篇 |
2021年 | 12篇 |
2020年 | 6篇 |
2019年 | 11篇 |
2018年 | 13篇 |
2017年 | 9篇 |
2016年 | 9篇 |
2015年 | 11篇 |
2014年 | 14篇 |
2013年 | 22篇 |
2012年 | 26篇 |
2011年 | 24篇 |
2010年 | 12篇 |
2009年 | 11篇 |
2008年 | 22篇 |
2007年 | 29篇 |
2006年 | 26篇 |
2005年 | 23篇 |
2004年 | 23篇 |
2003年 | 33篇 |
2002年 | 17篇 |
2001年 | 16篇 |
2000年 | 17篇 |
1999年 | 15篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1996年 | 4篇 |
1995年 | 6篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1992年 | 15篇 |
1991年 | 11篇 |
1990年 | 7篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1987年 | 5篇 |
1986年 | 12篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1979年 | 3篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1969年 | 2篇 |
1968年 | 4篇 |
1967年 | 2篇 |
1965年 | 2篇 |
排序方式: 共有537条查询结果,搜索用时 31 毫秒
21.
Enrique Rodríguez de Santiago Yuto Shimamura Mathieu Pioche Nikos Eleftheriadis Eduardo Albéniz Robert Bechara Philip Way Yan Chiu Carlos Guarner-Argente Alberto Herreros de Tejada Hugo Uchima Yusuke Fujiyoshi Thierry Ponchon Gonzalo González-Gete Simon Hew Marianette Murzi-Pulgar Virginia Matallana Sofía Parejo-Carbonell Fermín Estremera-Arévalo Haruhiro Inoue 《Gastrointestinal endoscopy》2021,93(4):839-849
22.
Kelly M. Morgan Jada G. Hamilton Heather Symecko Daniella Kamara Colby Jenkins Jenny Lester Kelsey Spielman Lydia E. Pace Camila Gabriel Jeffrey D. Levin Prince Rainier Tejada Anthony Braswell Vanessa Marcell Temima Wildman Bryan Devolder Robin Camhi Baum Jeremy N. Block Yuri Fesko Kenneth Offit 《Genetics in medicine》2022,24(3):564-575
PurposeThis study aimed to evaluate uptake and follow-up using internet-assisted population genetic testing (GT) for BRCA1/2 Ashkenazi Jewish founder pathogenic variants (AJPVs).MethodsAcross 4 cities in the United States, from December 2017 to March 2020, individuals aged ≥25 years with ≥1 Ashkenazi Jewish grandparent were offered enrollment. Participants consented and enrolled online with chatbot and video education, underwent BRCA1/2 AJPV GT, and chose to receive results from their primary care provider (PCP) or study staff. Surveys were conducted at baseline, at 12 weeks, and annually for 5 years.ResultsA total of 5193 participants enrolled and 4109 (79.1%) were tested (median age = 54, female = 77.1%). Upon enrollment, 35.1% of participants selected a PCP to disclose results, and 40.5% of PCPs agreed. Of those tested, 138 (3.4%) were AJPV heterozygotes of whom 21 (15.2%) had no significant family history of cancer, whereas 86 (62.3%) had a known familial pathogenic variant. At 12 weeks, 85.5% of participants with AJPVs planned increased cancer screening; only 3.7% with negative results and a significant family history reported further testing.ConclusionAlthough continued follow-up is needed, internet-enabled outreach can expand access to targeted GT using a medical model. Observed challenges for population genetic screening efforts include recruitment barriers, improving PCP engagement, and increasing uptake of additional testing when indicated. 相似文献
23.
Adela Alcolea María Jesús Suarez Manuel Lizasoain Pilar Tejada Fernando Chaves Elia Palenque 《Journal of clinical microbiology》2009,47(9):3043-3044
We report a case of conjunctival tuberculosis in a trainee microbiologist caused by direct inoculation. The resident strain was analyzed by DNA fingerprinting, and an identical pattern was found in an isolate from sputum handled by the resident. After 6 months of treatment, the patient was cured. 相似文献
24.
Elena Sánchez-Legaza Rosario Guerrero-Cauqui Jose Idelfonso Miranda Caravallo Carlos Murga Tejada 《Acta otorrinolaringologica espanola》2011,62(3):239-241
The solid fibrous solitary tumour of the oral cavity is an extremely rare entity. It is also of complicated diagnosis because of its extensive morphologic diversity (especially when there is a small amount of biopsied tissue) and because of its similarity to many mesenchymal injuries, mostly with hemangiopericytoma. The prognosis is reserved because of the few cases reported, mainly depending on tumour location and size. 相似文献
25.
Roger L Milne Ana Osorio Teresa Ramón Y Cajal Ana Vega Gemma Llort Miguel de la Hoya Orland Díez M Carmen Alonso Conxi Lazaro Ignacio Blanco Ana Sánchez-de-Abajo Trinidad Caldés Ana Blanco Bego?a Gra?a Mercedes Durán Eladio Velasco Isabel Chirivella Eva Esteban Carde?osa María-Isabel Tejada Elena Beristain María-Dolores Miramar María-Teresa Calvo Eduardo Martínez Carmen Guillén Raquel Salazar Carlos San Román Antonis C Antoniou Miguel Urioste Javier Benítez 《Clinical cancer research》2008,14(9):2861-2869
PURPOSE: It is not clear that the published estimates of the breast and ovarian cancer penetrances of mutations in BRCA1 and BRCA2 can be used in genetic counseling in countries such as Spain, where the incidence of breast cancer in the general population is considerably lower, the prevalence of BRCA2 mutations seems to be higher, and a distinct spectrum of recurrent mutations exists for both genes. We aimed to estimate these penetrances for women attending genetic counseling units in Spain. EXPERIMENTAL DESIGN: We collected phenotype and genotype data on 155 BRCA1 and 164 BRCA2 mutation carrier families from 12 centers across the country. Average age-specific cumulative risks of breast cancer and ovarian cancer were estimated using a modified segregation analysis method. RESULTS: The estimated average cumulative risk of breast cancer to age 70 years was estimated to be 52% [95% confidence interval (95% CI), 26-69%] for BRCA1 mutation carriers and 47% (95% CI, 29-60%) for BRCA2 mutation carriers. The corresponding estimates for ovarian cancer were 22% (95% CI, 0-40%) and 18% (95% CI, 0-35%), respectively. There was some evidence (two-sided P = 0.09) that 330A>G (R71G) in BRCA1 may have lower breast cancer penetrance. CONCLUSIONS: These results are consistent with those from a recent meta-analysis of practically all previous penetrance studies, suggesting that women with BRCA1 and BRCA2 mutations attending genetic counseling services in Spain have similar risks of breast and ovarian cancer to those published for other Caucasian populations. Carriers should be fully informed of their mutation- and age-specific risks to make appropriate decisions regarding prophylactic interventions such as oophorectomy. 相似文献
26.
27.
Max L Tejada Lanlan Yu Jianying Dong Kenneth Jung Gloria Meng Franklin V Peale Gretchen D Frantz Linda Hall XiaoHuan Liang Hans-Peter Gerber Napoleone Ferrara 《Clinical cancer research》2006,12(9):2676-2688
Activated fibroblasts are thought to play important roles in the progression of many solid tumors, but little is known about the mechanisms responsible for the recruitment of fibroblasts in tumors. Using several methods, we identified platelet-derived growth factor A (PDGFA) as the major fibroblast chemoattractant and mitogen from conditioned medium generated by the Calu-6 lung carcinoma cell line. In addition, we showed that Calu-6 tumors express significant levels of PDGFC, and that the levels of expression of these two PDGFRalpha ligands correlate strongly with the degree of stromal fibroblast infiltration into the tumor mass. The most intense expression of PDGFRalpha was observed in fibroblasts in the tumor outer rim. We subsequently showed that disrupting PDGFRalpha-mediated signaling results in significant inhibition of tumor growth in vivo. Furthermore, analysis of a compendium of microarray data revealed significant expression of PDGFA, PDGFC, and PDGFRalpha in human lung tumors. We propose that therapies targeting this stromal cell type may be effective in treating certain types of solid tumors. 相似文献
28.
29.
30.
J.?M.?QuintanaEmail author I.?Arostegui V.?Oribe I.?López de Tejada B.?Barrios I.?Garay 《Quality of life research》2005,14(3):815-825
Few studies have assessed the role of sociodemographic characteristics on outcomes after a cholecystectomy. Our goal was to evaluate the influence of age and gender on the health related quality of life (HRQoL) changes after cholecystectomy in this prospective observational study of consecutive patients undergoing cholecystectomy. Patients completed the SF-36 and the Gastrointestinal Quality of Life Index (GIQLI) before intervention and 3 months later. The influence of age, gender, and the pre-intervention health status on the HRQoL changes was studied by multivariate regression analysis. Older patients had poorer HRQoL and their post-intervention improvement was lower than younger patients. Compared with men, women had worse health status before the intervention measured with both HRQoL tools. In the unadjusted analysis women had greater improvements than men, measured by the GIQLI, but not with the SF-36. However, after controlling for other relevant variables, the SF-36 measured lower improvements in women more often than men, but the GIQLI showed similar results for both. For men and women, the lower the pre-intervention health status the higher the post-operative improvement. Women presented with worse health status before the intervention and less improvement post-operatively after adjustments. The pre-intervention health status has an important role explaining changes after the intervention. A gender-related difference exists between what a generic and a disease-specific HRQoL instrument captures when measuring HRQoL improvement after cholecystectomy. 相似文献