全文获取类型
收费全文 | 3436006篇 |
免费 | 241765篇 |
国内免费 | 9395篇 |
专业分类
耳鼻咽喉 | 48450篇 |
儿科学 | 111643篇 |
妇产科学 | 97386篇 |
基础医学 | 482517篇 |
口腔科学 | 97295篇 |
临床医学 | 309013篇 |
内科学 | 670909篇 |
皮肤病学 | 81807篇 |
神经病学 | 280509篇 |
特种医学 | 132816篇 |
外国民族医学 | 1122篇 |
外科学 | 517329篇 |
综合类 | 72835篇 |
现状与发展 | 11篇 |
一般理论 | 1303篇 |
预防医学 | 257327篇 |
眼科学 | 79181篇 |
药学 | 252795篇 |
12篇 | |
中国医学 | 7152篇 |
肿瘤学 | 185754篇 |
出版年
2018年 | 36198篇 |
2017年 | 28095篇 |
2016年 | 32283篇 |
2015年 | 36362篇 |
2014年 | 50293篇 |
2013年 | 75865篇 |
2012年 | 100118篇 |
2011年 | 106064篇 |
2010年 | 63989篇 |
2009年 | 61326篇 |
2008年 | 99622篇 |
2007年 | 106623篇 |
2006年 | 108140篇 |
2005年 | 104034篇 |
2004年 | 100437篇 |
2003年 | 97267篇 |
2002年 | 94159篇 |
2001年 | 160965篇 |
2000年 | 165035篇 |
1999年 | 139607篇 |
1998年 | 40183篇 |
1997年 | 35855篇 |
1996年 | 35499篇 |
1995年 | 34257篇 |
1994年 | 31589篇 |
1993年 | 29619篇 |
1992年 | 109145篇 |
1991年 | 105391篇 |
1990年 | 102395篇 |
1989年 | 99305篇 |
1988年 | 91602篇 |
1987年 | 89851篇 |
1986年 | 84874篇 |
1985年 | 81106篇 |
1984年 | 60796篇 |
1983年 | 51638篇 |
1982年 | 30940篇 |
1981年 | 27732篇 |
1979年 | 55278篇 |
1978年 | 39275篇 |
1977年 | 33856篇 |
1976年 | 31052篇 |
1975年 | 34045篇 |
1974年 | 40121篇 |
1973年 | 38513篇 |
1972年 | 36391篇 |
1971年 | 33954篇 |
1970年 | 31674篇 |
1969年 | 30550篇 |
1968年 | 28346篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
81.
S. Spinty H. Rogozinski G. T. Lealman J. E. Wraith 《Journal of inherited metabolic disease》2003,25(8):697-698
Summary: A female patient with isovaleric acidaemia had a successful outcome from pregnancy. 相似文献
82.
83.
84.
85.
86.
87.
Abnormal spinal interactions from hand afferents to forearm muscles in writer's cramp. 总被引:1,自引:0,他引:1
G Louren?o J-P Bleton C Iglesias M Vidailhet V Marchand-Pauvert 《Clinical neurophysiology》2007,118(10):2215-2226
OBJECTIVE: Spinal reflexes from hand to wrist muscles were investigated in writer's cramp. METHODS: Stimulus-triggered rectified EMG averages after ulnar nerve and cutaneous stimulation, in wrist flexors and extensors during tonic contraction, were compared in 18 controls and 19 patients. RESULTS: On the patient dystonic side, ulnar-induced EMG suppression was decreased in wrist extensors, and facilitation in wrist flexors modified dependent on the dystonic wrist posture during writing. No change was found on the patient non-dystonic side. Cutaneous stimulation increased wrist flexor EMG on both sides of the patients with normal wrist posture during writing, but had no effect in controls and patients with abnormal wrist posture. CONCLUSIONS: Comparison between cutaneous and mixed nerve stimuli suggests that spindle afferents from intrinsic hand muscles may mediate patients' ulnar-induced EMG modulations. Abnormal proprioceptive control was only observed on dystonic side, while bilateral unusual cutaneous control was found in patients. Changes in spinal transmission were partly related to the dystonic wrist posture, suggesting that systems involved in sensory processing can be differentially altered in writer's cramp. SIGNIFICANCE: Changes in spinal transmission, probably related to peripheral and/or cortical inputs, might either take part in primary or adaptive mechanisms underlying writer's cramp. 相似文献
88.
TG Berger F Kiesewetter C Maczek N Bauer M Lueftl G Schuler M Simon Jr 《Journal of the European Academy of Dermatology and Venereology》2006,20(2):178-183
Vitiligo and psoriasis are both common skin disorders. However, psoriasis strictly confined to pre-existing vitiligo areas is rare and suggests a causal relationship. We report here on two patients with a strict anatomical colocalization of vitiligo and psoriasis. The histopathological examinations showed typical changes for both diseases together with a dense infiltrate of CD4+ and CD8+ T cells. By immunohistochemistry, intracytoplasmatic granzyme B and tumour necrosis factor alpha (TNF-alpha) were detected within the T-cell population, suggesting the functional activity of these cells and the creation of a local T helper 1 (Th1)-cytokine milieu. Additionally, in one patient we could identify anti-melanocytic T cells by tetramer staining and enzyme-linked immunospot (ELISPOT) analysis. These skin-infiltrating lymphocytes might trigger, by the local production of Th-1 cytokines such as TNF-alpha and interferon-gamma (IFN-gamma), the eruption of psoriatic plaques in patients with a genetic predisposition for psoriasis. 相似文献
89.
90.
To determine if impaired energy metabolism might contribute to some aspects of Alzheimer disease (AD), including the vulnerability of the CA1 region of the hippocampal formation and the altered cytoskeleton evident in neurofibrillary tangles, we examined the effects of metabolic poisons on neuronal damage and cytoskeletal disruption in the hippocampal formation. Intrahippocampal injection of 3-nitropropionic acid (3-NP) and malonic acid resulted in neuronal death, particularly in CA1. Cytoskeletal disruption included loss of dendritic MAP2, but sparing of axonal τ. MK-801 (a noncompetitive NMDA receptor antagonist) did not atenuate the lesions produced by intrahippocampal injection of malonate. MK-801, however, was effective against intrastriatal malonate. Acute systemic 3-NP resulted in neuronal damage and cytoskeletal disruption in the CA1 region of the hippocampal formation, including an extensive loss of MAP2 immuno-reactivity, but sparing of τ. The neuronal loss in CA1 was delayed as compared to striatum. Chronic intraventricular infusion of 3-NP produced a different pattern of neuronal damage. Loss of τ-1 immuno-reactivity was observed in CA3 and CA1 s. oriens, whereas MAP2 immunostaining was preserved. These results demonstrate that chronic and acute administration of metabolic inhibitors produce distinct patterns of neuronal damage and cytoskeletal disruption. The results further suggest a differential involvement of the NMDA receptor in malonate-induced neuronal damage in striatum as compared to the hippocampus. The pattern of neuronal damage and cytoskeletal disruption observed following acute metabolic impairment resembled some aspects of neurofibrillary pathology in AD, but did not result in τ hyperphosphorylation. 相似文献