An evaluation of the suitability,readability, and quality of online resources for the self-management of depression

Objective

To evaluate online depression self-management (SM) resources based on their readability, suitability, and quality to determine their appropriateness for use by patients.

Tailoring an evidence-based lifestyle intervention to meet the needs of women Veterans with prediabetes

ABSTRACT

Prediabetes affects one-third of U.S. adults. Lifestyle change interventions, such as the Diabetes Prevention Program (DPP), can significantly lower type 2 diabetes risk, but little is known about how the DPP could be best adapted for women. This mixed-methods study assessed the impact of gender-tailoring and modality choice on DPP engagement among women Veterans with prediabetes. Participants were offered women-only groups and either in-person/peer-led or online modalities. Implementation outcomes were assessed using attendance logs, recruitment calls, and semi-structured interviews about patient preferences. Between June 2016 and March 2017, 119 women Veterans enrolled in the DPP (n = 51 in-person, n = 68 online). We conducted 22 interviews between August and September 2016 (n = 10 early-implementation) and March and July 2017 (n = 12 follow-up). Most interviewees preferred women-only groups, citing increased comfort, camaraderie, and mutual understanding of gender-specific barriers to lifestyle change. More women preferred online DPP, and those using this modality participated at higher rates. Most endorsed the importance of modality choice and were satisfied with their selection; however, selection was frequently based on participants’ personal circumstances and access barriers and not on a “preferred choice” of two equally accessible options. Patient engagement and program reach can be expanded by tailoring the DPP for population-specific needs.     

Isolated diffusing capacity reduction is a common clinical presentation in deployed Iraq and Afghanistan veterans with deployment‐related environmental exposures

Following deployment to Iraq and Afghanistan (“post‐9/11”), a spectrum of respiratory conditions has been reported; however, there are few published reports of objective physiologic data or later experience of symptoms and function. To better understand the post‐deployment clinical presentation, we conducted a retrospective review of pulmonary function testing in 143 veterans referred to our tertiary care clinic for post‐deployment health concerns. More than 75% of our sample had normal lung volumes and spirometry on pulmonary function testing; however, an isolated reduction in lung diffusing capacity (DLCO) was observed in 30% of our sample of post‐9/11 veterans. An isolated reduction in DLCO is a rare pattern in primary‐care seeking dyspneic patients, but is commonly associated with underlying pulmonary disease. Post‐9/11 veterans with respiratory complaints and an isolated reduction in DLCO should undergo further evaluation.     

金黄地鼠前列腺分泌蛋白对输卵管液糖蛋白的影响

目的：在整体水平探讨前列腺分泌蛋白对金黄地鼠输卵管液中糖蛋白的影响。方法：金黄地鼠雄鼠依据手术方式的不同分为3组，分别为假手术组（SH）、附属性腺全去组（TX）和腹前列腺组（VP）（仅存前列腺）。收集与各手术组交配后不同时间点（交配后0.5、2、4、6h）的输卵管液（每一时间点及每一组，n=3），输卵管液蛋白经SDS-聚丙烯酰胺凝胶电泳，考马斯亮蓝或阿仙蓝染色分析，应用蛋白电泳印迹后与系列某一种特异性糖基专一性结合凝集素反应，分析糖蛋白的变化。结果：不同组雄鼠交配及不同时间点收集输卵管液蛋白电泳谱类似，约15条主要条带。凝集素结合谱示，麦胚凝集素（WGA）结合的相对分子质量（Mr）为32000、35500、47000、52000糖蛋白见于6hVP组输卵管液，而6h TX组可见Mr为81000、128000条带；与豌豆凝集素（PSA）结合Mr为37500、32000糖蛋白仅见于6h VP组，而6h TX组缺乏；仅6hVP组可见与双花扁豆凝集素（DBA）结合Mr为52000、47000糖蛋白，而6h TX组缺乏。而0.5、2、4h时间点收集的输卵管液各凝集素结合谱相似。结论：前列腺分泌蛋白可影响修饰交配6h后的输卵管液中含乙酰氨基葡萄糖、N-乙酰半乳糖胺／半乳糖和甘露糖糖链的糖蛋白。这些糖蛋白可能在胚胎的发育过程中起作用。