全文获取类型
收费全文 | 3264篇 |
免费 | 223篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 107篇 |
妇产科学 | 51篇 |
基础医学 | 558篇 |
口腔科学 | 58篇 |
临床医学 | 263篇 |
内科学 | 637篇 |
皮肤病学 | 53篇 |
神经病学 | 410篇 |
特种医学 | 48篇 |
外科学 | 435篇 |
综合类 | 24篇 |
一般理论 | 7篇 |
预防医学 | 387篇 |
眼科学 | 50篇 |
药学 | 146篇 |
中国医学 | 5篇 |
肿瘤学 | 251篇 |
出版年
2023年 | 45篇 |
2022年 | 74篇 |
2021年 | 130篇 |
2020年 | 78篇 |
2019年 | 96篇 |
2018年 | 99篇 |
2017年 | 74篇 |
2016年 | 84篇 |
2015年 | 116篇 |
2014年 | 145篇 |
2013年 | 195篇 |
2012年 | 252篇 |
2011年 | 285篇 |
2010年 | 148篇 |
2009年 | 140篇 |
2008年 | 189篇 |
2007年 | 190篇 |
2006年 | 221篇 |
2005年 | 208篇 |
2004年 | 192篇 |
2003年 | 154篇 |
2002年 | 133篇 |
2001年 | 13篇 |
2000年 | 3篇 |
1999年 | 14篇 |
1998年 | 24篇 |
1997年 | 14篇 |
1996年 | 18篇 |
1995年 | 15篇 |
1994年 | 16篇 |
1993年 | 14篇 |
1992年 | 9篇 |
1991年 | 7篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 4篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1982年 | 6篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1978年 | 6篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1972年 | 3篇 |
1965年 | 3篇 |
1945年 | 4篇 |
排序方式: 共有3508条查询结果,搜索用时 15 毫秒
101.
102.
Stéphanie Tellier Karine Brochard Arnaud Garnier Flavio Bandin Brigitte Llanas Vincent Guigonis Mathilde Cailliez Christine Pietrement Olivier Dunand Sylvie Nathanson Aurélia Bertholet-Thomas Lydia Ichay Stéphane Decramer 《Pediatric nephrology (Berlin, Germany)》2013,28(6):911-918
Background
Rituximab (RTX) has recently showed promising results in the treatment of steroid-dependent idiopathic nephrotic syndrome (SDNS).Methods
This was a retrospective multicenter study of 18 children treated with RTX for SDNS, with a mean follow-up of 3.2 years. RTX was introduced because of side effects or relapses during therapy with immunosuppressive agents. The children received one to four infusions of RTX during the first course of treatment, and subsequent infusions were given due to CD19-cell recovery (CD19?>1 %; 54 % of children) or relapse (41 %), as well as systematically (5 %).Results
Treatment with RTX maintained sustained remission without relapse in 22 % of patients and increased the duration of remission in all other patients. The time between two successive relapses was 9 months in the absence of re-treatment and 24.5 months when infusions were performed at the time of CD19-cell recovery. At the last follow-up, 44.5 % of patients were free of oral drug therapy. Of those still receiving oral drugs, all doses had been decreased. No serious adverse events occurred.Conclusion
The results of this retrospective study confirm the efficacy and very good safety of RTX in the treatment of SDNS. The optimal therapeutic protocol seems to be a repeated single infusion at the time of CD19-cell recovery. 相似文献103.
Monica Sarto Piccolo Alfredo Gragnani Ricardo Piccolo Daher Marco de Tubino Scanavino Maria José de Brito Lydia Masako Ferreira 《Burns : journal of the International Society for Burn Injuries》2013
In measuring the quality of life of burn victims, it is essential that we find reliable and valid means. The Burn Sexuality Questionnaire (BSQ) is a specific instrument that assesses sexuality in the context of quality of life of burn victims. We set out to translate, validate and culturally adapt the BSQ into Brazilian Portuguese. The Portuguese version was applied to 80 patients. After translation, cultural adaptation was performed with 30 patients. We also tested the final version for reliability in 20 patients, and for face, content and construct validities in 30 patients, according to standard procedures. Total Cronbach's alpha was 0.87. Pearson's correlation was significant between scores for different time points. Construct validity was demonstrated with the correlation of the BSQ with the Burn Specific Health Scale – Revised (BSHS-R) questionnaire. It showed significant correlation between the BSQ social comfort domain and the BSHS-R affect and body image (p = 0.025), simple function ability (p = 0.008), work (p = 0.016) and treatment (p = 0.037) domains. This cultural adaptation of the BSQ suggests that it is a reliable tool and has construct validity for the social comfort domain. There is still need for a better-structured tool that could possibly evaluate functional and psychological aspects of sexuality, because one could easily overlook the psychosocial aspects of patients with major, complex burns. 相似文献
104.
Understanding which factors predict individual dissociative response during stressful situations is important to clarify the nature of dissociation and the mechanisms associated to its use as a coping strategy. The present study examined (1) whether experiential avoidance (EA), anxiety sensitivity (AS), depressive symptoms, and state anxiety concurrently predicted trait dissociation (TD)—absorption, amnesia, depersonalization, and total TD scores—and laboratory induced dissociation (LID); and (2) whether TD and catastrophizing predicted LID. We also examined whether catastrophizing mediated the relationships between both AS and depressive symptoms and LID. A total of 101 female undergraduate students participated in a cold pressor task, which significantly induced dissociation. Results of hierarchical regression analyses showed that AS at Time 1 (9 months before the experimental session), as well as depressive symptoms and catastrophizing at the time of the experiment (Time 2), predicted LID at Time 2. Depressive symptoms at Time 2 predicted total TD, absorption, and amnesia scores. AS at Time 1 and depressive symptoms at Time 2 predicted depersonalization. AS, depressive symptoms, and catastrophizing seem to facilitate the use of dissociative strategies by healthy individuals, even in response to non-traumatic but discomforting stress. 相似文献
105.
Purpose
We aimed to estimate the prevalence of suicidal behaviours, i.e. ideation and attempt, in the adult population of Belgium, and to explore their association with household composition.Methods
Data of 4,459 adults (25–64 years) from the 2004 Belgian Health Interview Survey were used for analyses. Bivariate and multivariate logistic regressions were used to calculate the odds of engaging in suicidal behaviours according to household type, further controlling for age, sex, income, employment status and social support.Results
Lifetime prevalence of ideation and attempts was 14 and 4.7 %, respectively. Current prevalence of ideation was 4.0 % and past year prevalence of attempts was 0.5 %. Compared to other household compositions, living alone (A) and as lone parent (P) increased the odds of lifetime and current suicidal thoughts (ORA 2.3, 95 % CI 1.7–2.9 and ORP 3.8, 95 % CI 1.9–7.7) and lifetime attempts (ORA 2.3, 95 % CI 1.4–3.6 and ORP 4.5, 95 % CI 2.4–8.5). When controlling for confounders, single person and single parent households still presented increased adjusted-odds of lifetime and current suicidal thoughts (a-ORA 1.8, 95 % CI 1.1–2.9 and a-ORP 2.3, 95 % CI 1.0–5.5). The likelihood of ever attempted suicide was also higher among single parent households (a-ORP 4.5, 95 % CI 2.4–8.5) after adjustment, but not among those living alone (a-ORA 1.4, 95 % CI 0.8–2.8).Conclusion
Living alone or as lone parent place adults at higher risk for suicide behaviour, and this is only partly explained by lower socio-economic status or poor perceived support. 相似文献106.
Song-Lin Ding Joshua J. Royall Phil Lesnar Benjamin A.C. Facer Kimberly A. Smith Yina Wei Kristina Brouner Rachel A. Dalley Nick Dee Tim A. Dolbeare Amanda Ebbert Ian A. Glass Nika H. Keller Felix Lee Tracy A. Lemon Julie Nyhus Julie Pendergraft Robert Reid Melaine Sarreal Nadiya V. Shapovalova Aaron Szafer John W. Phillips Susan M. Sunkin John G. Hohmann Allan R. Jones Michael J. Hawrylycz Patrick R. Hof Lydia Ng Amy Bernard Ed S. Lein 《The Journal of comparative neurology》2022,530(1):6-503
Increasing interest in studies of prenatal human brain development, particularly using new single-cell genomics and anatomical technologies to create cell atlases, creates a strong need for accurate and detailed anatomical reference atlases. In this study, we present two cellular-resolution digital anatomical atlases for prenatal human brain at postconceptional weeks (PCW) 15 and 21. Both atlases were annotated on sequential Nissl-stained sections covering brain-wide structures on the basis of combined analysis of cytoarchitecture, acetylcholinesterase staining, and an extensive marker gene expression dataset. This high information content dataset allowed reliable and accurate demarcation of developing cortical and subcortical structures and their subdivisions. Furthermore, using the anatomical atlases as a guide, spatial expression of 37 and 5 genes from the brains, respectively, at PCW 15 and 21 was annotated, illustrating reliable marker genes for many developing brain structures. Finally, the present study uncovered several novel developmental features, such as the lack of an outer subventricular zone in the hippocampal formation and entorhinal cortex, and the apparent extension of both cortical (excitatory) and subcortical (inhibitory) progenitors into the prenatal olfactory bulb. These comprehensive atlases provide useful tools for visualization, segmentation, targeting, imaging, and interpretation of brain structures of prenatal human brain, and for guiding and interpreting the next generation of cell census and connectome studies. 相似文献
107.
Long Kristin A. Chevalier Lydia Chu Andrea Guthrie Kate M. Kao Barbara Plante Wendy Lobato Debra 《Journal of autism and developmental disorders》2022,52(9):4100-4113
Journal of Autism and Developmental Disorders - Siblings describe positive and negative aspects of autism and often assume lifelong support roles. Less is known about cultural influences on sibling... 相似文献
108.
Qualls Lydia R. Hartmann Kathrin Paulson James F. Wells Nicole Kreiser 《Journal of autism and developmental disorders》2022,52(4):1678-1692
Journal of Autism and Developmental Disorders - Individuals with Autism Spectrum Disorder (ASD) and the Broad Autism Phenotype (BAP) are more likely than individuals with typical development (TD)... 相似文献
109.
Schacher Sylvia Dock-Rust Daniela Döpker Sandra Dryden Frauke Fundel Beatrice Hempel Dorothea Hidas Christine Hottenbacher Lydia Marohl Ranka Milicevic Dagmar Möhring Fereschta Roßbach-Wilk Elisabeth Russig Julia Spitznagel Nadja Walder Julia Wrede Julia Ullrich Greta 《Notfall & Rettungsmedizin》2022,25(5):348-349
Notfall + Rettungsmedizin - 相似文献
110.
Ferran Torner Josep M. Segur Rosendo Ullot Francisco Soldado Pedro Domenech Lydia DeSena Jorge Knorr 《International orthopaedics》2016,40(8):1683-1688