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41.
Jiyoung Ahn Christine B Ambrosone Peter A Kanetsky Chunqiao Tian Teresa A Lehman Silke Kropp Irmgard Helmbold Dietrich von Fournier Wulf Haase Marie Luise Sautter-Bihl Frederik Wenz Jenny Chang-Claude 《Clinical cancer research》2006,12(23):7063-7070
PURPOSE: Because radiotherapy exerts cytotoxic effects via generation of massive oxidative stress, we hypothesized that catalase, manganese superoxide dismutase, myeloperoxidase (MPO), and endothelial nitric oxide synthase (eNOS) genotypes might result in greater risk of radiotoxicity. EXPERIMENTAL DESIGN: Cases (n = 446) were Caucasian women with breast cancer who received radiotherapy following lumpectomy. Genotypes were determined by matrix-assisted laser desorption/ionization time-of-flight. The development of acute reactions (moist desquamation) associated with genotypes was modeled using the Cox proportional hazards model, accounting for cumulative biologically effective radiation dose. RESULTS: Genotypes associated with higher levels of reactive oxygen species (ROS) were not associated with risk of radiotoxicity. However, relationships between overweight/obesity [body mass index (BMI), >25] and radiotoxicity risk seemed to be modified by eNOS and MPO genotypes associated with higher generation of nitric oxide and ROS, respectively. Women with high BMI (>25) and eNOS GG genotypes were at more than a 6-fold increase in risk (hazard ratio, 6.39; 95% confidence interval, 2.53-16.15) compared with those with BMI <25, and for MPO, those with high BMI (>25) and GG genotypes also had greater risk of radiotoxicity (hazard ratio, 3.61; 95% confidence interval, 1.78-7.35) compared with those with BMI <25. Overweight/obesity was not a strong risk factor among women with other eNOS and MPO genotypes. Exploratory analysis using classification and regression trees indicated that total number of risk alleles contributed, in part, to acute toxicity outcomes among a subgroup of women. CONCLUSIONS: Associations between BMI and radiotoxicity risk may be most apparent among women with genotypes related to higher levels of oxidative stress. Regression trees may be useful in future studies to examine the contributions of multiple factors to individual susceptibility to adverse effects of cancer treatment. 相似文献
42.
Metabolism of porcine, human and salmon calcitonin in the rat 总被引:1,自引:0,他引:1
43.
Thomas Bronisch Jürgen Brunner Brigitta Bondy Dan Rujescu Gerd Bishof Isabella Heuser Bruno Müller-Oerlinghausen Barbara Hawellek Wolfgang Maier Marie Luise Rao Werner Felber Ute Lewitzka Jochen Oehler Andreas Broocks Fritz Hohagen Erik Lauterbach 《Archives of Suicide Research》2005,9(1):19-26
The subproject 1.5 "Neurobiology of Suicidal Behavior" is a multicenter study assessing peripheral parameters of the serotonergic, noradrenergic, and dopaminergic transmitter systems. Additionally, stress hormones and the lipid system as well as inhibitory and excitatory amino acids will be investigated. The different parameters are collected in cerebral spinal fluid (CSF), blood, and saliva. Patients with a depressive spectrum disorder with and without a suicide attempt (during the last three weeks) and being medication free for two weeks are included in the study. So far, 103 patients and controls have been recruited. The design and development of this project as well as interconnections with the others subprojects are described. Preliminary results about the stress hormone system and suicidality are presented. 相似文献
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46.
Screening of nine candidate genes for autism on chromosome 2q reveals rare nonsynonymous variants in the cAMP-GEFII gene 总被引:3,自引:0,他引:3
Bacchelli E Blasi F Biondolillo M Lamb JA Bonora E Barnby G Parr J Beyer KS Klauck SM Poustka A Bailey AJ Monaco AP Maestrini E;International Molecular Genetic Study of Autism Consortium 《Molecular psychiatry》2003,8(11):916-924
The results from several genome scans indicate that chromosome 2q21-q33 is likely to contain an autism susceptibility locus. We studied the potential contribution of nine positional and functional candidate genes: TBR-1; GAD1; DLX1; DLX2; cAMP-GEFII; CHN1; ATF2; HOXD1 and NEUROD1. Screening these genes for DNA variants and association analysis using intragenic single nucleotide polymorphisms did not provide evidence for a major role in the aetiology of autism. Four rare nonsynonymous variants were identified, however, in the cAMP-GEFII gene. These variants were present in five families, where they segregate with the autistic phenotype, and were not observed in control individuals. The significance of these variants is unclear, as their low frequency in IMGSAC families does not account for the relatively strong linkage signal at the 2q locus. Further studies are needed to clarify the contribution of cAMP-GEFII gene variants to autism susceptibility. 相似文献
47.
Analysis of reelin as a candidate gene for autism 总被引:2,自引:0,他引:2
Bonora E Beyer KS Lamb JA Parr JR Klauck SM Benner A Paolucci M Abbott A Ragoussis I Poustka A Bailey AJ Monaco AP;International Molecular Genetic Study of Autism 《Molecular psychiatry》2003,8(10):885-892
Genetic studies indicate that chromosome 7q is likely to contain an autism susceptibility locus (AUTS1). We have followed a positional candidate gene approach to identify relevant gene(s) and report here the analysis of reelin (RELN), a gene located under our peak of linkage. Screening RELN for DNA changes identified novel missense variants absent in a large control group; however, the low frequency of these mutations does not explain the relatively strong linkage results on 7q. Furthermore, analysis of a previously reported triplet repeat polymorphism and intragenic single nucleotide polymorphisms, using the transmission disequilibrium test, provided no evidence for association with autism in IMGSAC and German singleton families. The analysis of RELN suggests that it probably does not play a major role in autism aetiology, although further analysis of several missense mutations is warranted in additional affected individuals. 相似文献
48.
Daniel C. Damin Frederico S. Santos Renata Heck Mário A. Rosito Luise Meurer Lúcia M. Kliemann Rafael Roesler Gilberto Schwartsmann 《Digestive diseases and sciences》2010,55(8):2203-2210
Background
RC-3095, a synthetic gastrin-releasing peptide (GRP) antagonist, has been identified as a candidate compound for the treatment of tumor necrosis factor (TNF)-dependent chronic inflammatory conditions. 相似文献49.
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