全文获取类型
收费全文 | 26787篇 |
免费 | 1347篇 |
国内免费 | 153篇 |
专业分类
耳鼻咽喉 | 274篇 |
儿科学 | 559篇 |
妇产科学 | 626篇 |
基础医学 | 3410篇 |
口腔科学 | 1040篇 |
临床医学 | 1942篇 |
内科学 | 7206篇 |
皮肤病学 | 702篇 |
神经病学 | 2029篇 |
特种医学 | 502篇 |
外科学 | 4347篇 |
综合类 | 175篇 |
一般理论 | 3篇 |
预防医学 | 1938篇 |
眼科学 | 444篇 |
药学 | 1476篇 |
中国医学 | 122篇 |
肿瘤学 | 1492篇 |
出版年
2023年 | 209篇 |
2022年 | 440篇 |
2021年 | 962篇 |
2020年 | 438篇 |
2019年 | 892篇 |
2018年 | 1025篇 |
2017年 | 574篇 |
2016年 | 588篇 |
2015年 | 756篇 |
2014年 | 1101篇 |
2013年 | 1385篇 |
2012年 | 2197篇 |
2011年 | 2240篇 |
2010年 | 1326篇 |
2009年 | 1144篇 |
2008年 | 1806篇 |
2007年 | 1863篇 |
2006年 | 1717篇 |
2005年 | 1527篇 |
2004年 | 1418篇 |
2003年 | 1348篇 |
2002年 | 1240篇 |
2001年 | 159篇 |
2000年 | 130篇 |
1999年 | 170篇 |
1998年 | 192篇 |
1997年 | 148篇 |
1996年 | 146篇 |
1995年 | 124篇 |
1994年 | 100篇 |
1993年 | 84篇 |
1992年 | 73篇 |
1991年 | 55篇 |
1990年 | 51篇 |
1989年 | 41篇 |
1988年 | 46篇 |
1987年 | 35篇 |
1986年 | 22篇 |
1985年 | 39篇 |
1984年 | 36篇 |
1983年 | 40篇 |
1982年 | 46篇 |
1981年 | 45篇 |
1980年 | 44篇 |
1979年 | 18篇 |
1978年 | 26篇 |
1977年 | 27篇 |
1975年 | 22篇 |
1974年 | 21篇 |
1973年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
Manuel Diaz-Llopis Salvador García-Delpech David Salom Patricia Udaondo Francisco Bosch-Morell Arturo Quijada Francisco J Romero Luis Amselem 《Journal of ocular pharmacology and therapeutics》2007,23(4):343-350
PURPOSE: The aim of this study to analyze the preventive effect of high-dose infliximab in endotoxin-induced uveitis (EIU) in rabbits. METHODS: An experimental study was conducted on 64 rabbits. Salmonella typhimurium lipopolysaccharide endotoxin was intravitreally injected. Infliximab was intravenously (i.v.) injected 24 h before the intravitreal injection (20 mg/kg). The animals were randomly assigned to five groups: group A, saline intravitreal injection; group B, Infliximab i.v. group C, infliximab + saline; group D, intravitreal endotoxin and group E, infliximab i.v. + intravitreal endotoxin. With two masked observers, a microscopic examination of aqueous humor (cells, tumor necrosis factor [TNF] alpha) and aqueous protein level were performed 24 h after an endotoxin injection and 48 h after an infliximab infusion. RESULTS: Infliximab treatment, at a dose of 20 mg/kg, significantly improved all the parameters. Inflammatory cell infiltration was significantly reduced in the iris, ciliary body, and anterior chamber (U Mann-Whitney test, P = 0.01). Associated with a lower level of TNF-alpha and protein exudate in aqueous humor (U Mann-Whitney test, P = 0.01). CONCLUSIONS: Infliximab, at a dose of 20 mg/kg, is effective in the prophylaxis of the EIU. 相似文献
42.
43.
44.
Luis Requena Evaristo Sánchez Yus Esther Jiménez Elia Roo 《Journal of cutaneous pathology》1994,21(6):541-548
Cutaneous carcinoma histopathologically resembling nasopharyngeal carcinoma has been termed lymphoepithelioma-like carcinoma of the skin. We present an additional example of this rare cutaneous neoplasm that was located on the left temple of an 83-year-old woman. Serology for Epstein-Barr virus was negative, and exploration of the nasopharyngeal region disclosed no abnormalities. Histopathologically, the neoplasm consisted of a relatively well-circumscribed, dermal-hypodermal nodule composed of irregular aggregates of epithelial cells with vesicular nuclei, some of them in mitosis, and scant cytoplasm. A dense lymphocytic infiltrate was present within the neoplastic aggregates, obscuring the epithelial component, and at scanning magnification, the lesion closely resembled cutaneous lymphoma or pseudolymphoma. There was local sebaceous differentiation. Immunohistochemistry showed positivity in the epithelial component for AE1/AE3 and AEB-903 cytokeratins and negativity for 8–18 cylokeratins. The inflammatory infiltrate was positive for leukocyte common antigen, UCHL-1, L-26, Leu-22, and OPD-4 in variable proportions. Scattered cells within this inflammatory infiltrate were also positive for S-100 protein, vimentin, HAM-56, and MAC-387. In situ hybridization investigations for the presence of Epstein-Barr virus genomic DNA yielded negative results. Lymphoepithelioma-like carcinoma of the skin is a distinct cutaneous neoplasm of unknown histogenesis, although some foci of adnexal differentiation have been found in some specimens. The possibility of cutaneous metastasis from occult nasopharyngeal carcinoma should be ruled out.
Requena L, Sánchez Yus E, Jiménez E, Roo E. Lymphoepithelioma-like carcinoma of the skin: A light-microscopic and immunohistochemical study. 相似文献
Requena L, Sánchez Yus E, Jiménez E, Roo E. Lymphoepithelioma-like carcinoma of the skin: A light-microscopic and immunohistochemical study. 相似文献
45.
C. Vyvyan Howard Luis M. Cruz-Orive Hiroshi Yaegashi 《Acta neurologica Scandinavica》1992,85(S137):14-19
The recently developed method of total vertical projections is illustrated to estimate the total dendritic length of a human Substantia Nigra neuron. Next, the length of the different orders of dendritic branches, and the mean segment length for each order - commonly regarded as important parameters in neuron physiology - are also estimated. Finally, it is shown how to estimate the mean dendritic length in a population of neurons from vertical slices of arbitrary and unknown thickness. Being unbiased and highly efficient, the proposed methods offer interesting alternatives to current procedures used for the metric analysis of neuron arborizations. 相似文献
46.
Richard Lehman Frederick Andermann ré Olivier Prakash N. Tandon Luis F. Quesney Theodore B. Rasmussen 《Epilepsia》1994,35(6):1117-1124
Summary: It is not generally appreciated that intractable seizures involving the face area are amenable to surgical treatment. Twenty patients with onset of sensorimotor seizures in the face area of the pre- and postcentral gyri have been studied and surgically treated since 1948. Seizures started in the face, tongue, or throat, followed by diverse patterns depending on spread of seizure activity. Two patients had epilepsia partialis continua; 6 had either tonic or atonic drop attacks. All patients had pre- and postcentral face area resections, 12 in the dominant hemisphere. In addition, 3 had more extensive postcentral removal, 7 had temporal lobe, and 4 had small separate or contiguous frontal or parietal resection. Because the seizures were not sufficiently reduced by the first operation, 6 required reoperation; 4 of these patients had residual epileptiform activity on electrocorticogram (ECoG) after the first resection. Three patients had new neurologic signs that did not return to the preoperative level, but in 2 of them the deficit related mainly to higher resection in the central area. All but 2 of these 20 patients had at least moderate seizure reduction. Corticectomy can be performed for treatment of seizures arising in the lower central area and usually does not lead to significant permanent neurologic deficit. 相似文献
47.
Luis H. Ramirez Morbize Juliéron Marc Bonnay Serge Koscielny Zhongxin Zhao Alain Gouyette Jean-Nicolas Munck 《Investigational new drugs》1995,13(1):51-53
Suramin is an antitrypanosomal compound with confirmed efficacy against several human malignancies. It is generally assumed
that its mechanism of action includes the interaction with different growth factors, unlike most of the anticancer drugs.
Its anticancer activity has not been testedin vivo against squamous cell carcinoma. The purpose of this study was to assess the efficacy and toxicity of suraminin vivo andin vitro on the VX2 tumor model at therapeutic monitored plasma concentrations. We determined the pharmacokinetics of suramin in rabbits,
and modelized its administration in order to obtain plasma concentrations between 150 and 300 μg/ml throughout the treatment
course of 3 weeks. Under these conditions, antitumor effects of suramin were evaluatedin vivo by comparing liver tumor involvement in suramin-treated and control rabbits. Liver involvement was quantified by image analysis
andin vitro effects were also determined at the same concentrations.In vivo, suramin promoted liver tumor growth significantly (p<0.05), compared to untreated controls.In vitro, suramin significantly stimulated tumor cell growth at concentrations above 200 μg/ml (p<0.01). Suramin may have stimulatory
effects on tumor growth in squamous cell carcinoma at relevant plasma drug concentrations. Caution should be taken in further
trials in patients with squamous cell carcinomas. 相似文献
48.
49.
Fixation of cementless acetabular cups: A radiographic 4-8-year study of 102 porous-coated components 总被引:2,自引:0,他引:2
We studied fixation changes over time in 113 porous-coated Howmedica (PCA) cementless acetabular cups inserted in 90 patients 1984-1988. The mean follow-up was 5 years. Radiographic fixation was classified as stable, fibrous-stable, or unstable. 9 cups, 3 in neutral position and 6 vertical, were revised. At follow-up, 40/75 neutral cups were stable versus 7/27 vertical cups. Most stable cups and two thirds of the unstable cups were clinically good. After the first 2 years, 28/75 neutral cups and 10/27 vertical cups changed their fixation: 12 had improved fixation and 26 had a worse one. 相似文献
50.
Luis H Toledo-Pereyra 《Journal of investigative surgery》2006,19(4):211-218
Eminent surgeons who received the Nobel Prize in Physiology or Medicine for their work and accomplishments are considered Nobel Laureate surgeons. There are nine such distinguished individuals who achieved this award. In chronological order, from earliest to latest, we encounter: 1. Theodor Kocher, 1909, thyroid gland pathology; 2. Allvar Gullstrand, 1911, dioptrics of the eye; 3. Alexis Carrel, 1912, vascular suture and organ transplant; 4. Robert Barany, 1914, vestibular system; 5. Frederick Banting, 1923, discovery of insulin; 6. Walter Hess, 1949, midbrain function; 7. Werner Forssmannn, 1956, cardiac catheterization; 8. Charles Huggins, 1966, hormones and cancer; 9. Joseph Murray, 1990, organ transplantation. These extraordinary Nobel Laureate surgeons had in common four significant qualities expressed by four letters, CDFI, representing commitment, determination, focus, and innovation. The examples of a sustained path of accomplishment and success set by these unique personalities serve as a vivid guide for future generations of surgeons. 相似文献