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991.
In 2015, South Korea experienced the largest outbreak to date of the Middle East Respiratory Syndrome (MERS-CoV) outside the Middle East. Fears related to a potential spread of the disease led to an increased alert level as well as heightened media coverage in the neighboring Hong Kong. A cross-sectional survey (N = 533) among residents of Hong Kong was conducted to assess the relationships between the effects of outbreak-related mass media coverage, interpersonal communication, the perceived level of concern in one’s close environment, and the uptake of preventive measures. A serial multiple mediator model finds that interpersonal communication and higher perceived concern indirectly influence the effects of media coverage on the engagement in preventive actions. These results expand previous research on the mediating role of interpersonal communication and support assumptions about a modified two-step flow of communication in the context of a public health emergency. 相似文献
992.
The Hon Justice Michael Kirby AC CMG 《Psychiatry, Psychology and Law》2013,20(2):139-149
The author analyses the history of the classification of homosexuality as a psycho‐sexual disorder and looks to the role of the law in propagating misunderstandings about sexual orientation. Looking to the causes of homophobia, he highlights the need for it to be eliminated, contending that until this occurs hatred, discrimination, disadvantage and violence will persist He argues that those who cause these feelings, and not those whom they target are the ones who need the assistance of scientific psychology and psychiatry and that those who are their targets need the strong assistance, protection and equal justice of the law. 相似文献
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Disease‐associated BRCA2 mutations typically result in protein truncations that delete the phosphorylation‐regulated S3291 BRCA2 domain that interacts with Rad51. BRCA2 hereditary breast cancers are usually ER+, differing from BRCA1 hereditary cancers, which are usually ER?. We studied BRCA2 protein expression and S3291 phosphorylation in normal breast tissues and in sporadic breast cancers and observed that BRCA2 is expressed and phosphorylated in normal breast and 10 ER+ breast cancers but not in 10 ER? breast cancers. In order to study this correlation between ER and BRCA2 expression, we studied ER+ breast cancer cell lines. We found that a rapid increase in BRCA2 S3291 phosphorylation occurs following 17‐β‐oestradiol (E2) treatment. This increase seen in BRCA2 total and phospho‐S3291 protein levels was found to be unaffected with cycloheximide pre‐treatment, but decreased following tamoxifen, ICI 182,780 or roscovitine treatment. This suggests a requirement for ER and cdk (cyclin‐dependent kinase) in mediating the increased protein levels. MCF7 cell cycle distribution analysis following E2, in both the presence and absence of roscovitine (a cdk inhibitor), did not demonstrate any changes during an 8 h period, which further supports our hypothesis that mitogenic effects of E2 are not predominant at early time points. Studies with MG132 proteasome inhibitor and siRNA to skp2 support a model in which skp2‐mediated proteasomal degradation of BRCA2 rapidly degrades BRCA2 protein in the absence of hormone treatment, which likely inhibits this pathway. E2 was shown to improve survival of MCF7 cells upon radiation treatment and roscovitine partially reversed this effect. We have demonstrated that BRCA2 protein is specifically expressed in ER+ breast cancers and are investigating a pathway that may show a link between E2 action and BRCA2 protein function in breast cancer. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献
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Petra Steinacker Corinna Hendrich Anne-Dorte Sperfeld Sarah Jesse Stefan Lehnert Alice Pabst Christine A. F. von Arnim Felix M. Mottaghy Ingo Uttner Hayrettin Tumani Albert Ludolph Markus Otto 《Journal of neural transmission (Vienna, Austria : 1996)》2009,116(9):1169-1178
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders with heterogeneous clinical presentation but common neuropathological characteristics and pathophysiological substrates, which led to the view of ALS and FTLD representing two manifestations of a clinicopathological spectrum. For both diseases, changes in metabolism of beta-amyloid precursor protein (APP) are reported. In a pilot study, we analyzed cerebrospinal fluid from patients of the ALS-FTLD spectrum for APP processing products. ALS patients show elevated absolute levels of soluble APP and a shift towards the nonamyloidogenic APP processing pathway in contrast to patients with FTLD or ALS + FTLD. Changes in Aß pattern could be described, allowing separation of patients with pure FTLD from ALS + FTLD. Combination of sAPP and Aß values improves group differentiation. These findings may provide information on pathophysiological processes in the ALS-FTLD disease spectrum and could have impact in neurochemical diagnosis. We propose to expand this study to larger patient groups comprising followed up cases with known neuropathology. 相似文献
999.
Rubén Fernández-Santiago Sabine Hoenig Peter Lichtner Anne-Dorte Sperfeld Manu Sharma Daniela Berg Oliver Weichenrieder Thomas Illig Katharina Eger Thomas Meyer Johanna Anneser Christoph Münch Stephan Zierz Thomas Gasser Albert Ludolph 《Journal of neurology》2009,256(8):1337-1342
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease characterized by the selective death
of motor neurons in the motor cortex, brain stem and spinal cord. Recently, missense variants in the angiogenin gene (ANG), an angiogenic factor expressed in ventral horn motor neurons that is up-regulated by hypoxia, have been found in ALS patients
of Irish/Scottish, North American, Italian, French and Dutch descent. To investigate the role of ANG in the German population,
we screened for mutations by sequencing the entire coding region of the ANG gene in a large sample of 581 German ALS cases
and 616 sex- and age-matched healthy controls. We identified two heterozygous missense variants, F(−13)L and K54E, in two
German sporadic ALS cases but not in controls. Both missense variants are novel and have not been previously found in ALS
cases. Our results suggest that missense variants in the ANG gene play a role in ALS in the German population and provide further evidence to support the hypothesis that angiogenic factors
up-regulated by hypoxia are involved in the pathophysiology of ALS.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
1000.
CR de Andrade PF Leite AC Montezano DA Casolari A Yogi RC Tostes R Haddad MN Eberlin FRM Laurindo HP de Souza FMA Corr��a AM de Oliveira 《British journal of pharmacology》2009,157(4):568-580