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101.
钙和鸡冠花黄酮提取物对大鼠废用性骨质疏松的作用 总被引:4,自引:0,他引:4
目的探讨钙和鸡冠花黄酮提取物对废用性骨质疏松大鼠的作用,为骨质疏松的防治提供依据.方法选用健康SD大鼠40只,雄性.随机分为5组,第1、2组分别为正常对照和阳性对照,灌胃蒸馏水5 ml/(kg@d),第2~5组制造废用性骨质疏松大鼠模型,第3、4、5组为预防组,分别灌胃等量鸡冠花提取物,碳酸钙,鸡冠花提取物加钙溶液.实验8周后,测骨密度(BMD),股骨CT值,测血清MDA、SOD及24 h尿钙、羟脯氨酸(HOP)、尿肌酐含量等.结果阳性组与正常对照组比较股骨重、灰分重、CT值、血清钙下降,尿钙、尿HOP升高(P<0.05或0.01),预防组与阳性组比较股骨重、CT值显著增加,碳酸钙组、鸡冠花加钙组灰分重显著增加(P<0.05).与阳性组比较各预防组血清钙增加,尿钙、尿HOP减少(P<0.05或<0.01).鸡冠花组、鸡冠花加钙组与阳性组比较股骨BMD、血清SOD升高,MDA降低,单纯补钙组仅BMD升高(P<0.05或<0.01).结论鸡冠花提取物、钙对废用性骨质疏松大鼠骨质代谢均有促进作用,两者合用具有更好的预防效果,能延缓或减轻废用性骨质疏松的发生. 相似文献
102.
四种可溶性载体对骨形态发生蛋白在小鼠体内诱导成骨活性的影响 总被引:28,自引:0,他引:28
以四种可溶性物质作为牛骨形态发生蛋白(bBMP)的载体,通过实验观察哪种物质是bBMP的有效缓释载体。将聚乙烯吡咯烷酮(PVP)、葡聚糖、羟乙基淀粉(HES)、甘露醇分别与等量bBMP复合后,注射入小鼠股部肌肉,观察组织学成骨及测定标本内钙含量。结果,bBMP/PVP有良好成骨,吸收较快,未见炎症及排斥反应,其混悬液较稳定,具有良好的适针性及可注射性,bBMP/甘露醇只有很低成骨率。其余各组未见成骨。PVP对bBMP具有满意助溶、助悬及缓释载体作用,对bBMP活性无损害,生物相容性好。 相似文献
103.
建立了较完整的估计重油和沥青中饱和碳浓度数方法,其中包括环烷桥头碳、环烷甲基取代碳、环烷烷基(≥C2)取代碳等。基于理论分析,建立了估计环间的桥链和各种平均结构参数的方法,包括平均芳环环核数和环烷环环核数、芳环和环烷环烷工取代度、单元片上芳环和环烷环数。从实验数据出发,提出了烷基链长分布的公式。 相似文献
104.
African Americans experienced massive internal migrations that shifted more than 6 million Southern-born blacks to other sections of the United States over the past century, a trend that only recently has been reversed. Whenever mass migration takes place, there is an opportunity to examine the role of the native and relocated environments in the development of disease. This article examines those relationships for diabetes mellitus, a group of diseases that disproportionately affect African-Americans relative to other racial and ethnic groups in the United States. Age-specific and age-adjusted rates with 95% confidence intervals were calculated for males and females for combinations of five regions of birth and four regions of residence at time of death. Southern-born males had statistically significantly higher death rates from diabetes than did their counterparts who died in the same regions in 9 of 16 comparisons. For females, those born in the South had statistically significantly higher rates in 15 of 16 comparisons. The results of this study indicate that place of birth and early life experiences are statistically associated with diabetes mortality among African Americans regardless of place of residence at time of death. 相似文献
105.
106.
Resection was carried out in 1,025 of 1,654 patients with cancer of the esophagus or esophagogastric junction at the Peking Medical College Hospitals in China from 1953 through 1973. All cancers of the esophagus were squamous cell carcinomas except for five adenocarcinomas. A lesion localized within the esophageal wall was found in 55% and lymph node metastasis in 41.3% of the patients undergoing resection. All cancers of the esophagogastric junction were adenocarcinomas. The tumor had invaded beyond the boundaries of the stomach in 76.7% of these patients, and positive nodes were found in 61% of the patients. The rate of resectability was 81.2% for esophageal cancer and 74% for cancer of the esophagogastric junction. Surgical mortality after resection was 4.9% (50/1,025). The 5-year survival after resection was 20.9% (214/1,025). Better results were found following complete resection: 24% (210/875) for all patients, 28.2% (162/575) for patients with cancer of the esophagus, and 16% (48/300) for patients with cancer of the esophagogastric junction. Late survival at 10, 15, and 20 years after resection of esophageal cancer was 20%, 12%, and 7.4%, respectively. The favorable prognostic factors after resection of esophageal cancer were tumor of the lower third of the esophagus, the absence of lymph node involvement, and the presence of a localized lesion. The 5-year survival for patients with cancer of the lower third of the esophagus was 32.7%. It was 64.2% for patients with a localized lesion with negative nodes in this subgroup. 相似文献
107.
E. Pujade-Lauraine H. Lu S. Mirshahi J. Soria C. Soria A. Bernadou E. K. O. Kruithof H. R. Lijnen P. Burtin 《International journal of cancer. Journal international du cancer》1993,55(1):27-31
We studied the plasminogen activation system in tumor tissue by measuring the antigen level of the 2 plasminogen activators, tissue-type (t-PA) and urokinase-type (U-PA) and their inhibitors, plasminogen-activator inhibitors type-1 (PAI-1) and type-2 (PAI-2) in the tissue extracts of 43 human benign and malignant ovarian tumors. U-PA levels were significantly higher in malignant than in benign tumors. In addition, U-PA antigen levels were higher in the metastatic tissue of advanced disease (FIGO stage III) than in the primary localized tumor (FIGO stage I/II). Also PAI-1 concentrations tended to be higher in malignant than in benign tumors, but this difference was not statistically significant. In contrast, t-PA levels were lower in metastatic than in non-metastatic tumors, whereas PAI-2 levels were unrelated to the stage of ovarian malignancy. These results were integrated in a plasminogen-activation-dependent malignancy index (U-PA × PAI-1/t-PA). This index distinguished the different groups of benign ovarian tumors, localized and metastatic ovarian carcinomas better than U-PA levels. It could be useful as a prognostic indicator in ovarian cancer © 1993 Wiley-Liss, Inc. 相似文献
108.
Fictive oesophageal peristalsis evoked by activation of muscarinic acetylcholine receptors in rat nucleus tractus solitarii 总被引:1,自引:0,他引:1
The aim of the present study was to determine if muscarinic acetylcholine receptor-mediated peristaltic rhythmogenesis in the rat oesophagus is a central motor program that can be generated without peripheral sensory support. In anaesthetized male Sprague-Dawley rats, pressure-ejection of glutamate (10–20 pmol) and muscarine (5–10 pmol) in the subnucleus centralis of the nucleus tractus solitarii (NTSC ) evoked monophasic pressure waves and rhythmic oesophageal peristalsis, respectively, but did not change mean arterial blood pressure or respiration. Application of muscarine (50–100 pmol) to the NTS extraventricular surface evoked rhythmic multi-unit burst discharges in the compact formation of the nucleus ambiguus (AMBC ) that led to oesophageal peristalsis in a phase-locked manner. Evoked rhythmic AMBC activity persisted during neuromuscular blockade with curare, although the peak frequency of individual bursts was decreased. In a brainstem slice preparation, intracellular and whole cell patch recordings from AMBC neurones during focal stimulation of the NTSC region with muscarine revealed rhythmic depolarizing waves that showed a pattern similar to that of rhythmic oesophageal peristalsis. The present findings support the concept that medullary circuits comprising premotor neurones of the NTSC are intrinsically capable of generating rhythmic oesophagomotor output, but are subject to a powerful modulation by peripheral sensory feedback. 相似文献
109.
110.
医院融资经营提高资本利用质量 总被引:1,自引:0,他引:1
着重从资本运作中最主要的手段——融资,去剖析医院以融资方式实现医疗规模迅速扩张的全过程。介绍了经营租赁与融资租赁及其优缺点,并附案例加以说明。 相似文献