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81.
Christine K. Wagner Misty J. Eaton Kenneth E. Moore Keith J. Lookingland 《Brain research》1995,677(2):229
Potential efferent projections of A13 dopaminergic (DA) neurons were identified in the present study by examining the distribution of labelled fibers following iontophoretic injection of the anterogradely transported lectinPhaseolus vulgaris leucoagglutinin (PHA-L) into the medial zona incerta (MZI), the region of the diencephalon containing A13 DA neuronal perikarya. One week after injection, PHA-L labelled fibers were found throughout the brain with the heaviest labelling occurring ipsilateral to the injection site in the anterior hypothalamic area, lateral hypothalamus, lateral preoptic area, horizontal diagonal band of Broca, and parvocellular region of the paraventricular nucleus. Moderate labelling was observed in the ipsilateral median preoptic nucleus, lateral septum, lateral aspect of the bed nucleus of the stria terminalis, and central nucleus of the amygdala. Moderate labelling was also found in the contralateral MZI and parvocellular region of the paraventricular nucleus. Light labelling was detected in the ipsilateral medial preoptic area, supraoptic nucleus, ventromedial nucleus, arcuate nucleus, vertical limb of the diagonal band of Broca, and in the contralateral lateral hypothalamus. Few immunopositive fibers were present in the dorsomedial nucleus of the hypothalamus or the magnocellular region of the paraventricular nucleus. These results reveal that neurons located in the MZI (possibly A13 DA neurons) have ipsilateral efferent axonal projections to a variety of brain regions including the lateral hypothalamus, lateral preoptic area, and the limbic structures at the diencephalic-telencephalic juncture. 相似文献
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The purpose of the present study was to characterize opioid receptor-mediated regulation of incertohypothalamic dopaminergic (DA) neurons in the rat brain by examining the acute effects of selective mu or kappa opioid receptor agonists and antagonists on concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) in the medial zona incerta (MZI) and the dorsomedial hypothalamic nucleus (DMN) which contain cell bodies and terminals, respectively, of these neurons. Morphine caused a dose- and time-related increase in concentrations of DOPAC in MZI and DMN; this stimulatory effect was blocked by the mu opioid receptor antagonist naltrexone. In contrast, activation or blockade of kappa opioid receptors following administration of U-50,488 or nor-binaltorphimine, respectively, had no effect on DOPAC concentrations in either the MZI or DMN. The basal activity of incertohypothalamic DA neurons and their response to morphine was similar in male and female rats. Morphine also increased the concentrations of 5-hydroxyindoleacetic acid in MZI and DMN, indicating that morphine increases the activity of 5-hydroxytryptamine (5HT) neurons projecting to these regions. This might suggest that morphine-induced activation of incertohypothalamic DA neurons is mediated by 5HT neurons; but 5,7-dihydroxytryptamine-induced lesions of 5HT neurons did not alter the ability of morphine to increase DOPAC concentrations in MZI and DMN. These results indicate that the stimulatory effects of mu opioid receptor activation on incertohypothalamic DA neurons is not dependent upon the presence of 5HT neurons. 相似文献
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Ultrasonography in testicular torsion 总被引:1,自引:0,他引:1
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The effects of an acute injection of morphine on the activities of mesotelencephalic, tuberoinfundibular and incertohypothalamic dopamine (DA) neurons was estimated by measuring: the rate of turnover of DA (decline after alpha-methyltyrosine); and the concentration of the DA metabolite, dihydroxyphenylacetic acid (DOPAC), in brain regions containing cell bodies or terminals of these neurons (i.e. nucleus accumbens, striatum, median eminence and various hypothalamic nuclei). The rate of turnover of DA and the concentration of DOPAC were increased in nucleus accumbens and striatum and decreased in the median eminence 60 min after the administration of morphine (10 mg/kg, s.c.). Morphine increased the rate of turnover of DA and the concentration of DOPAC in brain regions containing both cell bodies (periventricular nucleus and medial zona incerta) and terminals (medial preoptic, preopticosuprachiasmatic and dorsomedial nuclei) of incertohypothalamic DA neurons. The effects of morphine in all brain regions were blocked by pretreatment with naltrexone. These results indicate that incertohypothalamic DA neurons are stimulated by the acute administration of morphine, and in this respect they resemble the extrahypothalamic mesotelencephalic DA neurons rather than hypothalamic tuberoinfundibular DA neurons. 相似文献
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Scrotal masses with a uniformly hyperechoic pattern 总被引:3,自引:0,他引:3
90.