Longitudinal standards for height and height velocity are essential to monitor for appropriate linear growth. We aimed to construct standards in Korean children and adolescents through the population-based longitudinal Kangwha study. Our study was a part of a community-based prospective cohort study from 1986 to 1999 with 800 school children. Height and height velocity were recorded annually from age 6 until final height. Results were compared with cross-sectional data from the 2007 Korean National Growth Charts. Final height was 173.5 cm in boys and 160.5 cm in girls. Although final height was similar between longitudinal and cross-sectional standards, the mean height for age was higher in the longitudinal standard by 1-4 cm from age 6 until the completion of puberty. Using the longitudinal standard, age at peak height velocity (PHV) was 12 in boys and 10 in girls; height velocity at PHV was 8.62 cm/yr in boys and 7.07 cm/yr in girls. The mean height velocity was less than 1 cm/yr at age 17 in boys and 15 in girls. Thus, we have presented the first report of longitudinal standards for height and height velocity in Korean children and adolescents by analyzing longitudinal data from the Kangwha cohort. 相似文献
Two electron‐deficient tetracyclic monomers, 6,9‐dibromo‐7,8‐bis(octyloxy)‐11H‐indeno[2,1‐b] quinoxalin‐11‐one ( M1 ) and 1,3‐bis(5′‐bromo‐4′‐hexylthiophen‐2‐yl)‐9H‐indeno[1,2‐b]thieno[3,4‐e]pyrazin‐9‐one ( M2 ), are synthesized through condensation of ninhydrin with aromatic diamines in good yields. Copolymerization of M1 with thiophene (Th) and dithieno[3,2‐b:2′,3′‐d]silole (DTS), and M2 with DTS affords three new D–A conjugated copolymers, P1 – P3, respectively . The optical, electrochemical, and photovoltaic properties of P1–P3 are investigated. P3 exhibits a broad absorption (300–1100 nm) and a low bandgap of 1.24 eV. Solar cells based on P3 /[6,6]‐phenyl C71 butyric acid methyl ester (PC71BM) blends afford a power conversion efficiency of 1.93% and a very broad spectral response (300–1020 nm).
BackgroundAtrial fibrosis causes abnormal conduction through the atria, creating a substrate for atrial fibrillation (AF). In a rabbit model, rapid atrial pacing produces significant atrial fibrosis and the substrate for AF maintenance. This atrial remodeling is a potential therapeutic target.ObjectiveTo evaluate the effects of the losartan on atrial fibrosis.MethodsThirty rabbit AF models were produced by rapid atrial stimulation. They were randomly divided into three groups: sham group, rapid atrial pacing group, and rapid atrial pacing with losartan group. We performed AF vulnerability studies, atrial histologic, and molecular analyses after 4 weeks.ResultsOnly rabbits in the rapid atrial pacing group developed sustained AF (30 min, 4of 10 rabbits). Treatment with losartan resulted in a significant reduction in left atrial fibrosis and AF duration (P<.01). real-time polymerase chain reaction analyses demonstrated the drug's effects on the expression of Collagen I, Collagen III, and TGF-β/Smads signaling pathway.ConclusionsThe treatment of losartan results in significantly reduced atrial fibrosis and AF vulnerability. Pharmacological therapy targeted at the fibrotic substrate itself may play an important role in the management of AF. 相似文献
The development of bifunctional electrocatalysts based on highly efficient non-noble metals is pivotal for overall water splitting. Here, a composite electrode of Co3O4@CoWP is synthesized, where an ultrathin layer composed of Co3O4 nanoparticles is grown on CoWP nanowires supported on a carbon cloth (CC). The Co3O4@CoWP/CC electrode exhibits excellent electrocatalytic activity and improved kinetics towards both the oxygen and hydrogen evolution reactions (OER and HER). The Co3O4@CoWP/CC electrode achieves a current density of 10 mA cm−2 at a low overpotential of 269 mV for the OER and −10 mA cm−2 at 118 mV for the HER in 1.0 M KOH solution. The voltage applied to a two-electrode water electrolyzer for overall water splitting, while employing the Co3O4@CoWP/CC electrode as both an anode and a cathode, in order to reach a current density of 10 mA cm−2, is 1.61 V, which is better than that for the majority of reported non-noble electrocatalysts. Moreover, the Co3O4@CoWP/CC electrode exhibits good stability over 24 h with slight attenuation. The electrode benefits from the enhanced adsorption of oxygen intermediates on Co3O4 during the OER, the increased ability for water dissociation and the optimized H adsorption/desorption ability of CoWP nanowires during the HER. This study provides a feasible approach for cost-effective and high-performance non-noble metal bifunctional catalysts for overall water electrolysis.A hierarchical 3D self-supporting CoWP nanowire array shelled with an ultrathin Co3O4 nanolayer on carbon cloth (Co3O4@CoWP/CC) exhibits superior overall water electrolysis capability.相似文献
As a critical enzyme for the uric acid production, xanthine oxidase (XO) has emerged as a primary drug target for antihyperuricemic therapy. A hierarchical virtual screening integrating both ligand-based and structure-based approaches was applied herein to identify potent XO inhibitors. Four compounds, which were previously reported as XO inhibitors, were recognized through the virtual screening protocol, and compound H3, which is distinct from the structures of known XO inhibitors, was identified as a new chemotype inhibitor with IC50 of 2.6 μM. The binding mode of H3 was further investigated by molecular docking and molecular dynamics (MD) simulation. The results suggested the feasibility to discover new chemotypes of XO inhibitors via integrated virtual screening strategies.A new chemotype of XO inhibitor with the IC50 of 2.6 μM was identified by a hierarchical virtual screening strategy.相似文献