全文获取类型
收费全文 | 578篇 |
免费 | 94篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 41篇 |
妇产科学 | 12篇 |
基础医学 | 86篇 |
口腔科学 | 33篇 |
临床医学 | 111篇 |
内科学 | 136篇 |
皮肤病学 | 14篇 |
神经病学 | 22篇 |
特种医学 | 38篇 |
外科学 | 23篇 |
综合类 | 15篇 |
预防医学 | 58篇 |
眼科学 | 24篇 |
药学 | 27篇 |
肿瘤学 | 34篇 |
出版年
2023年 | 11篇 |
2021年 | 8篇 |
2020年 | 6篇 |
2019年 | 4篇 |
2018年 | 20篇 |
2017年 | 12篇 |
2016年 | 11篇 |
2015年 | 15篇 |
2014年 | 19篇 |
2013年 | 28篇 |
2012年 | 10篇 |
2011年 | 18篇 |
2010年 | 24篇 |
2009年 | 36篇 |
2008年 | 19篇 |
2007年 | 12篇 |
2006年 | 8篇 |
2005年 | 15篇 |
2004年 | 9篇 |
2003年 | 7篇 |
2002年 | 14篇 |
2001年 | 7篇 |
2000年 | 14篇 |
1999年 | 19篇 |
1998年 | 22篇 |
1997年 | 38篇 |
1996年 | 38篇 |
1995年 | 28篇 |
1994年 | 22篇 |
1993年 | 18篇 |
1992年 | 6篇 |
1991年 | 13篇 |
1990年 | 10篇 |
1989年 | 17篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 14篇 |
1985年 | 12篇 |
1984年 | 8篇 |
1983年 | 6篇 |
1982年 | 10篇 |
1981年 | 8篇 |
1980年 | 10篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1968年 | 2篇 |
排序方式: 共有675条查询结果,搜索用时 0 毫秒
81.
Pecorara M; Casarino L; Mori PG; Morfini M; Mancuso G; Scrivano AM; Boeri E; Molinari AC; De Biasi R; Ciavarella N 《Blood》1987,70(2):531-535
In this study, we used DNA polymorphisms for carrier detection and prenatal diagnosis of hemophilia A in a large group of Italian families. The restriction fragment length polymorphisms (RFLPs) investigated were the intragenic polymorphic Bc/I site within the factor VIII gene; the extragenic multiallelic Taq I system at the St14 locus; and the extragenic Bg/II site at the DX13 locus. The factor VIII probe was informative in 30%, St14 in 82%, and DX13 in 60% of obligate carriers. The combination of factor VIII-Bc/I and St14-Taq I showed that 91% of obligate carriers were heterozygotes for one or both; with all three probes, only 4% of obligate carriers were noninformative. In families clearly segregating for hemophilia A, RFLP analysis allowed us to define the carrier status for the hemophilia A gene in all 27 women tested. RFLP analysis allowed us to exclude the carrier status in 39 of 45 female relatives of sporadic patients. The combination of RFLP analysis and biological assay of factor VIII allowed us to identify a de novo mutation in the maternal grandfather in 7 of 12 of the families with sporadic cases, for which members of three generations were available for study. Nine of 10 couples requesting prenatal diagnosis provided informative RFLP DNA pattern. Carrier status was excluded in two women, two fetuses were shown to be female, and prenatal diagnosis was carried out in five pregnancies by DNA analysis. Prenatal testing was successful in three instances and failed in two because a sufficient amount of chorionic villous DNA was not obtained for the analysis. 相似文献
82.
An 11-yr-old child with mild chronic hemolytic anemia was found to have decreased red cell hexokinase activity in spite of the reduced mean age of her red cell population. Similar decreases in red cell hexokinase activity were documented in the patient's parents and in one sib. The red cells were morphologically normal. Red cell 2,3-DPG levels were normal and ATP and glucose-6-phosphate levels were diminished. The kinetic properties, electrophoretic mobility, and thermal stability of the residual red cell hexokinase were normal or nearly so. Glucose consumption of the hexokinase-deficient cells was not appreciably decreased, probably because less of the potent inhibitor glucose-6- phosphate was present in the erythrocytes. It is likely, although not certain, that in this patient nonspherocytic hemolytic anemia resulted from hexokinase deficiency. 相似文献
83.
84.
An evaluation of the ‘Yaka Ŋarali’’ Tackling Indigenous Smoking program in East Arnhem Land: Yolŋu people and their connection to ŋarali’ 下载免费PDF全文
85.
86.
Role of transforming growth factor beta in peritoneal fibrosis 总被引:11,自引:0,他引:11
SUMMARY: Technique survival of peritoneal dialysis is seriously limited by the development of peritoneal fibrosis. the mesothelial cell layer lining the peritoneum is important in the pathogenesis of peritoneal fibrosis. Mesothelial cells are able to produce transforming growth factor beta (TGF-β), and respond to stimulation by this cytokine. In this review, we will detail the evidence available so far for the role of the complex interaction between TGF-β and mesothelial cells in the development of peritoneal fibrosis. 相似文献
87.
88.
89.
The head nurse occupies an important position in the nursing unit Concerning leadership style, a distinction is traditionally made between consideration and initiating structure Sometimes a third style is distinguished as well, namely 'production-orientated' leadership In a study of 561 nurses from 16 general hospitals in The Netherlands, the influence of two leadership styles upon the reactions of nurses (job satisfaction, experienced meaningfulness, health complaints and absenteeism) to their work situations was examined, namely the styles of social (i e consideration) and instrumental leadership (a combination of the styles initiating structure and production-onentated) The separate effects of the two styles were studied, as well as the connection between combinations of leadership styles and reactions The results indicate that social leadership contributes positively to nurses' reactions to their job Instrumental leadership, on the other hand, leads to health complaints From the analyses of combinations of leadership styles it appears that nurses are most satisfied if the head nurse pays much attention to both dimensions of leadership For health complaints, a tendency in this directions is also found Finally, it becomes clear that nurses with a great need for autonomy prefer a different type of leadership from nurses with little need for autonomy 相似文献
90.