全文获取类型
收费全文 | 864篇 |
免费 | 32篇 |
国内免费 | 78篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 42篇 |
妇产科学 | 7篇 |
基础医学 | 97篇 |
口腔科学 | 15篇 |
临床医学 | 142篇 |
内科学 | 177篇 |
皮肤病学 | 22篇 |
神经病学 | 8篇 |
特种医学 | 287篇 |
外科学 | 25篇 |
综合类 | 21篇 |
预防医学 | 25篇 |
眼科学 | 1篇 |
药学 | 76篇 |
肿瘤学 | 28篇 |
出版年
2023年 | 3篇 |
2021年 | 2篇 |
2020年 | 1篇 |
2018年 | 6篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 9篇 |
2014年 | 11篇 |
2013年 | 15篇 |
2012年 | 13篇 |
2011年 | 4篇 |
2010年 | 23篇 |
2009年 | 33篇 |
2008年 | 13篇 |
2007年 | 60篇 |
2006年 | 4篇 |
2005年 | 19篇 |
2004年 | 7篇 |
2003年 | 13篇 |
2002年 | 10篇 |
2001年 | 15篇 |
2000年 | 13篇 |
1999年 | 19篇 |
1998年 | 66篇 |
1997年 | 72篇 |
1996年 | 50篇 |
1995年 | 62篇 |
1994年 | 36篇 |
1993年 | 36篇 |
1992年 | 16篇 |
1991年 | 17篇 |
1990年 | 13篇 |
1989年 | 34篇 |
1988年 | 33篇 |
1987年 | 23篇 |
1986年 | 27篇 |
1985年 | 43篇 |
1984年 | 18篇 |
1983年 | 12篇 |
1982年 | 25篇 |
1981年 | 14篇 |
1980年 | 24篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 14篇 |
1976年 | 15篇 |
1975年 | 9篇 |
1970年 | 1篇 |
排序方式: 共有974条查询结果,搜索用时 5 毫秒
971.
A Chanson† N Cardinault† E Rock† JF Martin† P Souteyrand‡ M D'Incan‡ P Brachet† 《Journal of the European Academy of Dermatology and Venereology》2008,22(1):94-100
Background In the last two decades, there has been an increasing use of isotretinoin (13‐cis‐retinoic acid or 13‐CRA) for treatment of severe, and recently mild and moderate, acne in Westernized populations. Recent human and animal studies emphasized alterations caused by 13‐CRA administration on folate‐dependent, one‐carbon metabolism. Folate deficiency and subsequent hyperhomocysteinemia increase the risk of degenerative diseases. Objectives We determine whether a short‐term supplementation with 13‐CRA alters folate status and homocysteinemia in young and elderly healthy human subjects. Methods Twenty young and 20 elderly (age mean, 26.1 and 65.4 years, respectively) healthy male volunteers were supplemented with ~0.5 mg/kg/day of 13‐CRA for 28 days. Fasting plasma concentrations of 13‐CRA, 5‐methyltetrahydrofolate (5‐mTHF) as the main circulating form of folate, and homocysteine (Hcy), as well as haematologic parameters and biochemical markers of liver and renal function, were measured at baseline and at the end of supplementation. Statistical analyses were carried out using two‐way anova and standard tests. Results In both groups, isotretinoin supplementation caused a dramatic increase in the circulating concentration of 13‐CRA and its derivatives. It also led to significant increases in serum triglyceride (P < 0.0001) and creatinine (P = 0.002) concentrations and γ‐glutamyltranspeptidase activity (P = 0.0001) and decrease in serum level of urea (P = 0.027). However, the latter four parameters remained within normal ranges. These changes were accompanied by a 17.7% and 13.5% decrease in the plasma level of 5‐mTHF (P = 0.001) in the young and elderly volunteers, respectively. Supplementation with 13‐CRA did not cause significant variations in their plasma Hcy concentration. However, the latter parameter seemed to respond differently in each group of age (P = 0.046). Conclusions Our data indicate that a 28‐day supplementation with isotretinoin alters the plasma folate in young and old healthy individuals. This stresses the necessity of studying the long‐term effects of retinoid therapy on folate status and homocysteinemia in acne patients, given that alteration in the latter parameters is known to increase the risk of degenerative diseases. 相似文献
972.
Aurima Stankuniene Mindaugas Stankunas Joaquim JF Soares Mark Avery M Gabriella Melchiorre Francisco Torres-Gonzalez Raimondas Radziunas Algirdas Baranauskas Jutta Lindert 《Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences》2012,20(1):78
Background
The use of medicines by elderly people is a growing area of concern in social pharmacy. A significant proportion of older people do not follow the recommendations from physicians and refrain from buying prescribed medications. The aim of this study is to evaluate associations between self-rated health, somatic complaints and refraining from buying prescribed medications by elderly people.Findings
Data was collected in a cross-sectional study in 2009. We received 624 completed questionnaires (response rate – 48.9%) from persons aged 60–84 years living in Kaunas (Lithuania). Somatic complaints were measured with the 24 item version of the Giessen Complaint List (GBB-24). Logistic regression (Enter model) was used for evaluation of the associations between refraining from buying medications and somatic complaints. These associations were measured using odds ratio (OR) and calculating the 95% confidence interval (CI).The mean scores in total for the GBB scale and sub-scales (exhaustion, gastrointestinal and cardiovascular) were lowest among respondents who did not refrain from buying prescribed medications (means for GBB-24 scale: 21.04 vs. 24.82; p=0.001). Logistic regression suggests that somatic complaints were associated with a increased risk of refraining from buying prescribed medications (OR=1.35, 95% CI=1.15-1.60).Conclusions
Somatic complaints were significantly associated with the decision to refrain from buying prescribed medications. 相似文献973.
MJ Huijbers J Spijker AR Donders DJ van Schaik P van Oppen HG Ruhé MB Blom WA Nolen J Ormel GJ van der Wilt W Kuyken P Spinhoven AE Speckens 《BMC psychiatry》2012,12(1):125-11
Background
Depression is a common psychiatric disorder characterized by a high rate of relapse and recurrence. The most commonly used strategy to prevent relapse/recurrence is maintenance treatment with antidepressant medication (mADM). Recently, it has been shown that Mindfulness-Based Cognitive Therapy (MBCT) is at least as effective as mADM in reducing the relapse/recurrence risk. However, it is not yet known whether combination treatment of MBCT and mADM is more effective than either of these treatments alone. Given the fact that most patients have a preference for either mADM or for MBCT, the aim of the present study is to answer the following questions. First, what is the effectiveness of MBCT in addition to mADM? Second, how large is the risk of relapse/recurrence in patients withdrawing from mADM after participating in MBCT, compared to those who continue to use mADM after MBCT?Methods/design
Two parallel-group, multi-center randomized controlled trials are conducted. Adult patients with a history of depression (3 or more episodes), currently either in full or partial remission and currently treated with mADM (6?months or longer) are recruited. In the first trial, we compare mADM on its own with mADM plus MBCT. In the second trial, we compare MBCT on its own, including tapering of mADM, with mADM plus MBCT. Follow-up assessments are administered at 3-month intervals for 15?months. Primary outcome is relapse/recurrence. Secondary outcomes are time to, duration and severity of relapse/recurrence, quality of life, personality, several process variables, and incremental cost-effectiveness ratio.Discussion
Taking into account patient preferences, this study will provide information about a) the clinical and cost-effectiveness of mADM only compared with mADM plus MBCT, in patients with a preference for mADM, and b) the clinical and cost-effectiveness of withdrawing from mADM after MBCT, compared with mADM plus MBCT, in patients with a preference for MBCT.Trial registration
ClinicalTrials.gov: NCT00928980 相似文献974.