全文获取类型
| 收费全文 | 995506篇 |
| 免费 | 69613篇 |
| 国内免费 | 1484篇 |
专业分类
| 耳鼻咽喉 | 13800篇 |
| 儿科学 | 25751篇 |
| 妇产科学 | 24508篇 |
| 基础医学 | 141256篇 |
| 口腔科学 | 30746篇 |
| 临床医学 | 85420篇 |
| 内科学 | 199058篇 |
| 皮肤病学 | 20764篇 |
| 神经病学 | 77794篇 |
| 特种医学 | 38243篇 |
| 外国民族医学 | 79篇 |
| 外科学 | 160740篇 |
| 综合类 | 18309篇 |
| 现状与发展 | 1篇 |
| 一般理论 | 260篇 |
| 预防医学 | 67216篇 |
| 眼科学 | 22514篇 |
| 药学 | 76709篇 |
| 3篇 | |
| 中国医学 | 2396篇 |
| 肿瘤学 | 61036篇 |
出版年
| 2019年 | 7088篇 |
| 2018年 | 10960篇 |
| 2017年 | 8212篇 |
| 2016年 | 9026篇 |
| 2015年 | 10812篇 |
| 2014年 | 13967篇 |
| 2013年 | 20382篇 |
| 2012年 | 29673篇 |
| 2011年 | 30478篇 |
| 2010年 | 17312篇 |
| 2009年 | 16126篇 |
| 2008年 | 29180篇 |
| 2007年 | 30453篇 |
| 2006年 | 31421篇 |
| 2005年 | 30094篇 |
| 2004年 | 28782篇 |
| 2003年 | 27388篇 |
| 2002年 | 26786篇 |
| 2001年 | 56078篇 |
| 2000年 | 58331篇 |
| 1999年 | 47823篇 |
| 1998年 | 10926篇 |
| 1997年 | 9602篇 |
| 1996年 | 9738篇 |
| 1995年 | 9062篇 |
| 1994年 | 8381篇 |
| 1993年 | 7691篇 |
| 1992年 | 35598篇 |
| 1991年 | 34019篇 |
| 1990年 | 32800篇 |
| 1989年 | 31941篇 |
| 1988年 | 29043篇 |
| 1987年 | 28300篇 |
| 1986年 | 26354篇 |
| 1985年 | 25211篇 |
| 1984年 | 17923篇 |
| 1983年 | 15196篇 |
| 1982年 | 7869篇 |
| 1979年 | 15822篇 |
| 1978年 | 10635篇 |
| 1977年 | 9088篇 |
| 1976年 | 7904篇 |
| 1975年 | 8650篇 |
| 1974年 | 10496篇 |
| 1973年 | 9885篇 |
| 1972年 | 9362篇 |
| 1971年 | 8864篇 |
| 1970年 | 8439篇 |
| 1969年 | 7936篇 |
| 1968年 | 7203篇 |
排序方式： 共有10000条查询结果，搜索用时 0 毫秒
71.
Miguel A. Sanz Pau Montesinos Haesook T. Kim Guillermo J. Ruiz-Argüelles María S. Undurraga María R. Uriarte Lem Martínez Rafael H. Jacomo Homero Gutiérrez-Aguirre Raul A. M. Melo Rosane Bittencourt Ricardo Pasquini Katia Pagnano Evandro M. Fagundes Edo Vellenga Alexandra Holowiecka Ana J. González-Huerta Pascual Fernández Javier De la Serna Salut Brunet Elena De Lisa José González-Campos José M. Ribera Isabel Krsnik Arnold Ganser Nancy Berliner Raul C. Ribeiro Francesco Lo-Coco Bob L?wenberg Eduardo M. Rego 《Annals of hematology》2015,94(8):1347-1356
72.
Efstathios T. Pavlidis 《Journal of investigative surgery》2019,32(2):137-142
Purpose/aim: To focus on current aspects of primary thyroid lymphoma (PTL), which is a rare clinical entity usually manifested by a rapidly growing mass in the neck that can cause pressure symptoms.
Materials and Methods: Relevant papers in PubMed published through June 2017 were selected to track updated information about PTL with an emphasis on diagnosis and novel therapeutic management.
Results: The most frequent cases include non-Hodgkin lymphoma derived from B-cells, mainly diffuse large B-cell lymphoma (DLBCL) followed by mucosa-associated lymphoid tissue (MALT) lymphoma or a mixed type. Other subtypes are less common. Lymphomas derived from T-cells and Hodgkin lymphomas are extremely rare. Hashimoto's autoimmune thyroiditis has been implicated as a risk factor for lymphoma. At the molecular level, the Wnt5a protein and its receptor Ror2 are involved in the course of the disease. Ultrasonography, fine needle aspiration (FNA) biopsy, and core or open biopsy combined with new diagnostic facilities contribute to an accurate diagnosis. An increased potential exists for a cure without the need for a radical surgical procedure. Modern chemoradiation therapy plus the monoclonal antibody rituximab, which acts against CD20, have limited the need for surgical interventions and provide an excellent outcome in most cases. However, some cases have resulted in treatment failure or recurrence.
Conclusions: A multidisciplinary approach must be used to define the management policy in each case. Future efforts by researchers are likely to be focused on the molecular level. 相似文献
73.
Oliver Sartor MD Daniel Heinrich MD Neil Mariados MD Maria José Méndez Vidal MD Daniel Keizman MD Camilla Thellenberg Karlsson MD Avivit Peer MD Giuseppe Procopio MD Stephen J. Frank MD Kalevi Pulkkanen MD Eli Rosenbaum MD Stefano Severi MD José Trigo MD Lucia Trandafir MD Volker Wagner MD Rui Li MS Luke T. Nordquist MD 《The Prostate》2019,79(14):1683-1691
74.
75.
76.
77.
Die Anaesthesiologie - Das Management des schwierigen Atemwegs ist eine präklinische Schlüsselqualifikation. Für Notärzte mit hohem Erfahrungsgrad im Atemwegsmanagement sind... 相似文献
78.
Hanna Lee Mary K. Tan Andrew T. Yan Paul Angaran Paul Dorian Claudia Bucci Jean C. Gregoire Alan D. Bell Martin S. Green Peter L. Gross Allan Skanes Charles R. Kerr L. Brent Mitchell Jafna L. Cox Vidal Essebag Brett Heilbron Krishnan Ramanathan Carl Fournier Shaun G. Goodman 《The Canadian journal of cardiology》2019,35(2):160-168
Background
Physicians treating nonvalvular atrial fibrillation (AF) assess stroke and bleeding risks when deciding on anticoagulation. The agreement between empirical and physician-estimated risks is unclear. Furthermore, the association between patient and physician sex and anticoagulation decision-making is uncertain.Methods
We pooled data from 2 national primary care physician chart audit databases of patients with AF (Facilitating Review and Education to Optimize Stroke Prevention in Atrial Fibrillation and Coordinated National Network to Engage Physicians in the Care and Treatment of Patients with Atrial Fibrillation Chart Audit) with a combined 1035 physicians (133 female, 902 male) and 10,927 patients (4567 female and 6360 male).Results
Male physicians underestimated stroke risk in female patients and overestimated risk in male patients. Female physicians estimated stroke risk well in female patients but underestimated the risk in male patients. Risk of bleeding was underestimated in all. Despite differences in risk assessment by physician and patient sex, > 90% of patients received anticoagulation across all subgroups. There was modest agreement between physician estimated and calculated (ie, CHADS2 score) stroke risk: Kappa scores were 0.41 (0.35-0.47) for female physicians and 0.34 (0.32-0.36) for male physicians.Conclusions
Our study is the first to examine the association between patient and physician sex influences and stroke and bleeding risk estimation in AF. Although there were differences in agreement between physician estimated stroke risk and calculated CHADS2 scores, these differences were small and unlikely to affect clinical practice; further, despite any perceived differences in the accuracy of risk assessment by sex, most patients received anticoagulation. 相似文献79.
C. Jacquet F. Goehringer E. Baux J.A. Conrad M.O. Ganne Devonec J.L. Schmutz G. Mathey H. Tronel T. Moulinet I. Chary-Valckenaere T. May C. Rabaud 《Médecine et maladies infectieuses》2019,49(2):112-120
Objective
The teaching hospital of Nancy, France, implemented a specific multidisciplinary care pathway (French acronym AMDPL) to improve the management of patients presenting with Lyme borreliosis (LB) suspicion. We aimed to assess the first year of activity of this care pathway.Patients and methods
We included all patients managed in the AMDPL pathway from November 1, 2016 to October 31, 2017. The first step was a dedicated Lyme disease consultation with an infectious disease specialist. Following this consultation, the LB diagnosis was either confirmed and adequate treatment was prescribed, or a differential diagnosis was established and patients received adequate management, or further investigations were required and patients were offered multidisciplinary management as part of a day hospitalization.Results
A total of 468 patients were included. LB diagnosis was confirmed in 15% of patients (69/468), 49% of patients received a differential diagnosis, and 26% (122/468) of patients had the LB diagnosis ruled out without receiving any other diagnosis.Conclusions
This is to our knowledge the first multidisciplinary center implemented in France for the management of patients presenting with LB suspicion related to polymorphous signs and symptoms. Several diagnoses could be confirmed or corrected, although some symptoms and complaints could not be explained. This cohort could improve our knowledge of LB and its differential diagnoses. 相似文献80.