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The effects of recombinant human erythropoietin (rhEPO, RecormonR, CAS 122312-54-3) on the differential leucocyte counts and platelets of rabbits were investigated after the repeated application of a single dose of rhEPO. Therefore, 150 IU rhEPO (n = 5), 300 IU rhEPO (n = 6), or 600 IU rhEPO (n = 5) per animal was injected once on three separate occasions with an interval of 5–6 weeks between each injection. Six animals were used to study the potential effect of the solvent alone.rhEPO showed a significant time effect on the differential leucocyte counts and platelets of rabbits. The decrease in total white blood cells count (WBC) on the third, fourth and sixth day after rhEPO administration was due to a decrease in lymphocytes. These results support the hypothesis that the enhanced demand of one cell line leads to a down-modulation of the production of other cell line(s). 相似文献
23.
Farsin Hamzei Michel Rijntjes Joystone Gbadamosi Kornelius Fuchs Cornelius Weiller Alexander Münchau 《Movement disorders》2003,18(8):959-961
We report on a woman with a an 8-year history of multiple system atrophy with predominance of parkinsonism who developed jaw-locking oromandibular dystonia within hours after insertion of ill-fitting dentures. Dystonia spread rapidly to involve other facial muscles and the larynx causing stridor with respiratory failure necessitating crush intubation. 相似文献
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Anatomically, the thigh is well covered by soft tissue in the form of the muscles surrounding the shaft. In the assessment of the severity of an injury, not only the obvious skin wound but also the mechnism of the trauma has to be considered. The extent and severity of the soft tissue damage cannot usually be fully established until later in the course of treatment, when necrosis of the skin, the subcutaneous fat and the musculature and also compartment syndrome or a secondary disturbance of perfusion may become obvious. Therefore, when extensive soft tissue injuries are present, following the primary débridement, a repeat wound débridement after 24–48 hours is generally indicated. Only after consolidation of the wounds and the successful treatment of any infection is definitive soft tissue reconstruction performed. The main danger in the treatment of soft tissue injuries of the thigh is underestimation of their total extent. 相似文献
26.
F.?W. Ahnefeld J. Barth W. Dick A. Doenicke T. Fuchs H. Gervais H. Laubenthal H. L?llgen W. Lorenz H.?H. Mehrkens G.?H. Meuret H. M?llmann S. Piepenbrock B. Przybilla R. Ring W. Schmutzler G. Schultze-Werninghaus J. Schüttler H.?P. Schuster P. Sefrin M. Tryba J. Zander M. Zenz 《Der Anaesthesist》1994,43(4):211-222
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Human papillomavirus (HPV) type 16 DNA is frequent in invasive cervical cancers. Among 43 patients with invasive cervical cancer, HPV-16-positive tumors spread to the parametrial and pelvic lymph nodes significantly more often than did HPV-16-negative tumors (P less than 0.05). Demonstration of HPV-16 DNA in invasive cervical cancers may be an additional prognostic factor for this disease. 相似文献
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The platelet and the neuron: Two cells in focus in migraine 总被引:1,自引:0,他引:1
Reports of platelet abnormalities in migraine are abundant, and the present paper discusses the role of platelets in the migraine aetiology. Platelets are considered good models for pre- and post-synaptic functions in serotonergic neurons. We propose that migraine is associated with a lowered threshold for stimulus response in both platelets and serotonergic neurons and that the alterations in platelet function reflect central serotonergic disturbances. The platelet abnormalities in migraine approach those found in depression, and there are several links between the two disorders. The clinical significance of platelet hyperactivity in migraineurs for the occurrence of thrombotic disorders is also discussed. Studies of platelet functions in migraine, using platelets as models for serotonergic neurons, may broaden our understanding of the neuronal processes that take place during a migraine attack. The platelet can also be an investigative tool for better understanding of the modes of action of anti-migraine drugs. 相似文献