全文获取类型
收费全文 | 546篇 |
免费 | 43篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 28篇 |
妇产科学 | 9篇 |
基础医学 | 90篇 |
口腔科学 | 11篇 |
临床医学 | 132篇 |
内科学 | 82篇 |
皮肤病学 | 1篇 |
神经病学 | 21篇 |
特种医学 | 52篇 |
外国民族医学 | 1篇 |
外科学 | 57篇 |
综合类 | 9篇 |
预防医学 | 54篇 |
眼科学 | 7篇 |
药学 | 16篇 |
中国医学 | 1篇 |
肿瘤学 | 15篇 |
出版年
2022年 | 5篇 |
2021年 | 17篇 |
2020年 | 6篇 |
2018年 | 6篇 |
2017年 | 6篇 |
2016年 | 13篇 |
2015年 | 25篇 |
2014年 | 30篇 |
2013年 | 33篇 |
2012年 | 9篇 |
2011年 | 18篇 |
2010年 | 21篇 |
2009年 | 18篇 |
2008年 | 22篇 |
2007年 | 14篇 |
2006年 | 19篇 |
2005年 | 18篇 |
2004年 | 17篇 |
2003年 | 13篇 |
2002年 | 18篇 |
2001年 | 13篇 |
2000年 | 10篇 |
1999年 | 8篇 |
1998年 | 13篇 |
1997年 | 17篇 |
1996年 | 8篇 |
1995年 | 6篇 |
1994年 | 13篇 |
1993年 | 7篇 |
1992年 | 7篇 |
1991年 | 14篇 |
1990年 | 5篇 |
1989年 | 11篇 |
1988年 | 9篇 |
1987年 | 12篇 |
1986年 | 11篇 |
1985年 | 14篇 |
1984年 | 11篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1980年 | 8篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 3篇 |
1976年 | 7篇 |
1975年 | 9篇 |
1972年 | 5篇 |
1971年 | 3篇 |
1968年 | 3篇 |
1966年 | 2篇 |
排序方式: 共有589条查询结果,搜索用时 93 毫秒
41.
42.
43.
We report a 21-year-old woman who has moderate to severe pulmonary hypertension, short stature, dysmorphic appearance, lipodystrophy and sclerodactyly-like involvement of her extremities. Cognitive development is in the low-average range. Various diagnoses have been suggested over the years, but none seem to fit her clinical presentation exactly. We suggest that she may have a previously undescribed connective tissue disorder with primary pulmonary involvement. 相似文献
44.
Ferrara E Lemire J Grimm PC Reznik VM Mendoza SA Leake JA Benador NM 《Pediatric nephrology (Berlin, Germany)》2004,19(1):114-117
Peritonitis is the most common complication and the leading cause of death in pediatric peritoneal dialysis (PD) patients. According to the most recent data available from the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS), approximately 25% of pediatric PD patients who die succumb to infection. There are no reported cases of Mycobacterium tuberculosis (MTB) or Mycobacterium avium-intracellulare peritonitis in the NAPRTCS registry. With an increasing incidence of MTB worldwide and the impairment of cellular immunity in chronic renal failure patients, it is not surprising that mycobacterium peritonitis can occur in PD patients. We report two pediatric PD patients with mycobacterial peritoneal infection diagnosed over an 11-year period at our institution. One patient presented with a malfunctioning Tenckhoff catheter and again 3 years later with hyponatremia and ascites. The other presented with recurrent culture-negative peritonitis. These cases illustrate the importance of more extensive evaluation of PD complications, to include evaluation for mycobacterium with special media or peritoneal biopsy, in the above clinical settings if the routine work-up is unrevealing. 相似文献
45.
Rodger GL 《Revista latino-americana de enfermagem》2004,12(5):816-820
Nursing leadership has become a major theme of discussions in many countries. The phenomenon is also present in nursing as the profession is redesigning and reinventing itself in all domains of practice. This paper discusses the development of global nursing leaders through doctoral education in the context of 21st century realities. Next, two meanings of global leadership of nursing are reviewed. Finally, doctoral education is focused by looking at worldviews and the challenges ahead in preparing global nursing leaders for the 21st century. 相似文献
46.
The early development of the neural tube has been well studied in animals and humans. After axial determinants have been accomplished the processes of primary and secondary neurulation take place. Successful completion results in a spinal cord that has arisen from primary neurulation and a lower sacro-coccygeal portion from secondary neurulation. The latter region is the site of numerous skin-covered clinical lesions, which include tumors and malformations. A listing of selected features in 764 cases of skin-covered sacrococcygeal lesions is presented. The manner in which these lesions arise and the potential for genetic factors being responsible is discussed. 相似文献
47.
Van Damme-Lombaerts R Webb NA Hoyer PF Mahan J Lemire J Ettenger R McMahon L Cambon N Boger R Kovarik JM;Everolimus Study Group 《Pediatric transplantation》2002,6(2):147-152
Everolimus (Certican; RAD), a novel macrolide with potent immunosuppressive and anti-proliferative activities, prevents acute rejection in adult recipients of renal transplantation. This phase I trial conducted in stable pediatric renal transplant patients examined the single-dose pharmacokinetics, safety, and tolerability of everolimus in combination with cyclosporin A (CsA; Neoral) and corticosteroids, with or without azathioprine. Nineteen pediatric patients were enrolled and received a single 1.2 mg/m2 dose of everolimus. Everolimus was safe and well tolerated, with a low incidence of adverse events reported and none judged to be related to the study medication. Everolimus administration did not increase infection rates or produce clinically significant changes in vital signs or changes in electrocardiograms. Apparent clearance and volume of distribution of everolimus increased with age, weight, and body surface area in a generally linear manner across the pediatric demographic ranges. Compared with adults from a previous study, apparent clearance (L/h) and distribution volume (L) were lower in pediatric patients, whereas the elimination half-life was similar. Single-dose everolimus co-administration did not affect the steady-state pharmacokinetics of CsA. Based on this information, pediatric patients will need a dose scaled down for body size, but can probably maintain the same twice-daily dosing schedule used in adults. 相似文献
48.
We report on a female infant with postaxial polydactyly of the hands, preaxial polydactyly of the right foot, cleft palate, microglossia and tongue hamartomata consistent with an oral-facial-digital syndrome (OFDS). The patient also had optic nerve colobomata, a Dandy-Walker malformation, micrognathia and apneic spells. This combination of clinical features has not been previously reported. This patient either expands the clinical features of one of the existing OFDS or represents a new variant. A review of the literature highlights the difficulties in making a specific diagnosis because of the different classification systems that exist in the literature. 相似文献
49.
50.