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81.
Alaiya AA Al-Mohanna M Aslam M Shinwari Z Al-Mansouri L Al-Rodayan M Al-Eid M Ahmad I Hanash K Tulbah A Bin Mahfooz A Adra C 《International journal of oncology》2011,38(4):1047-1057
Prostate adenocarcinoma often presents at a late stage, due to a lack of early clinical symptoms and lack of accurate objective markers. This study aimed to identify and validate proteomics-based biomarkers useful for prostate cancer diagnosis and to establish a marker-panel for prostate cancer and benign prostate hyperplasia (BPH). Global protein expression patterns in fresh tissue specimens from 8 patients with prostate carcinoma and 16 with BPH were analyzed by two-dimensional gel electrophoresis. Differentially expressed proteins were identified by MALDI-TOF mass spectrometry. We compared our results with those of published studies and defined a set of common biomarkers. We identified 22 differentially expressed proteins between BPH and prostate carcinomas. The up-regulated proteins in cancer compared to BPH included protein disulfide-isomerase, 14-3-3-protein, Enoyl CoA-hydrase, prohibitin and B-tubulin β-2. Keratin-II, desmin, HSP71, ATP-synthase-β-chain and creatine kinase-β-chain were down-regulated. Survey of the literature showed that 15 of our 22 identified proteins have been previously reported to differ in their expression levels between BPH and prostate cancer by other laboratories. The expression patterns of these biomarkers could successfully cluster BPH and adenocarcinomas as well as prostate cancer of low and high Gleason scores. This study validates protein-biomarkers that can be useful for accurate diagnosis and prognostic monitoring of prostate adenocarcinoma. Despite varied prevalence of the disease between different ethnic populations (i.e., high in Sweden, low in Saudi Arabia); the biomarkers indicate that BPH and prostate cancers are biologically 'homogeneous' in their protein expression patterns across wide geographical regions. 相似文献
82.
Adouani A Bouguila J Abdelali MA Ben Aicha M Landolsi A Hellali M Zitouni K Mahri I Zairi I 《Annales de chirurgie plastique et esthétique》2008,53(5):435-440
Infantile cutaneous hemangioma is a benign vascular tumour present at 10% of the infants. It forms part of the group of the vascular tumours in the classification of international society for vascular anomalies (ISSVA). Usual surgical attitude is abstention and surgery is proposed only in order to treat sequelae. But some particular situations require early surgery to avoid functional impairment, deformation or growth delay due to the lesion's development. Using our observations, we recall the epidemiology, the physiopathology, the clinical aspects, the particularities of the facial localizations and their treatments. In these localizations the time intervenes like a fourth dimension that is going to modify, to improve or to aggravate the prognosis. Treatment requires a strategy and precocious surgery. We insist on the fact that the dogma of the therapeutic abstention remained true for a majority of children with small size hemangioma and that a precocious surgery must be proposed for some localizations in the face. 相似文献
83.
Peer Reviewed: Developmental Perspectives on Nutrition and Obesity From Gestation to Adolescence
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Terry T. Huang Layla Esposito Jennifer O. Fisher Julie A. Mennella Deanna M. Hoelscher 《Preventing chronic disease》2009,6(3)
Obesity results from a complex combination of factors that act at many stages throughout a person''s life. Therefore, examining childhood nutrition and obesity from a developmental perspective is warranted. A developmental perspective recognizes the cumulative effects of factors that contribute to eating behavior and obesity, including biological and socioenvironmental factors that are relevant at different stages of development. A developmental perspective considers family, school, and community context. During gestation, risk factors for obesity include maternal diet, overweight, and smoking. In early childhood, feeding practices, taste acquisition, and eating in the absence of hunger must be considered. As children become more independent during middle childhood and adolescence, school nutrition, food marketing, and social networks become focal points for obesity prevention or intervention. Combining a multilevel approach with a developmental perspective can inform more effective and sustainable strategies for obesity prevention. 相似文献
84.
Layla Aitlhadj 《Mechanisms of ageing and development》2010,131(5):364-365
The nematode Caenorhabditis elegans is a popular model organism that is used to study longevity and aging. One drawback of nematode lifespan assays is the labour intensive separation of offspring from adults during the reproductive period. To circumvent this, the worm community frequently adds 5-fluoro-2′-deoxyuridine (FUdR), a drug that induces parental sterility, to the nematode culture. Here, we report that FUdR causes a significant artefactual increase in the longevity of tub-1 mutants which is not observed in wild-type nematodes. This suggests that the effect of FUdR is not neutral and the mechanism of action may result in misleading data, or indeed the misinterpretation of gerontogenes. 相似文献
85.
Kassem L Lopez V Hedeker D Steele J Zandi P;Bipolar Disorder Consortium NIMH Genetics Initiative McMahon FJ 《The American journal of psychiatry》2006,163(10):1754-1759
OBJECTIVE: Bipolar affective disorder is clinically heterogeneous, and clinical features that run in families may help define more homogeneous phenotypes. The authors sought to establish whether polarity at illness onset, which is related to severity and course, is a familial feature of bipolar affective disorder. METHOD: The authors studied 971 subjects from 507 families ascertained through sibling pairs with bipolar I or schizoaffective bipolar disorder. Self-reported ages at onset of mania and major depression were used to code polarity at onset as manic, major depressive, or both (mania and major depression in the same onset year). Familial clustering was estimated by using mixed-effects regression analysis, and the relationship between polarity at onset and several other clinical features was assessed. As a preliminary test of genetic validity, the authors assessed the impact of polarity at onset on genetic linkage findings previously detected in this sample. RESULTS: Polarity at onset was significantly familial in this sample. This largely reflected relative pairs concordant for mania at onset, which occurred significantly more frequently than would be expected by chance. Mania at onset substantially increased the genetic linkage signal on chromosome 16p (maximum lod score=4.5) but had no effect on linkage to chromosome 6q. Mania at onset occurred at a later age on average than major depression at onset and was less likely to be complicated by panic attacks or alcoholism. CONCLUSIONS: Polarity at illness onset is a familial feature of bipolar affective disorder and is associated with important clinical indicators, which may help define more homogeneous subtypes of bipolar affective disorder. 相似文献
86.
Jader L 《Neuroepidemiology》2007,28(2):65-78
This pragmatic work was undertaken to assist commissioners of health services in Wales in their planning for future provision of services for neurological and neurosurgical patients. A literature search, which was carried out to ascertain the epidemiology of neurological and neurosurgical disorders in Wales, revealed limited epidemiological surveys of patients in Wales, while other literatures although outdated were still relevant. More recent national reports, published by professional bodies and patients' organisations, were also identified. These disorders were also grouped according to their aetiology and symptoms into 13 groups. Using all the available literature, total estimates of annual incidence and point prevalence of these disorders were arrived at. We can conclude that approximately 5.8% of the population in Wales are affected by neurological and neurosurgical disorders that include headaches, traumatic and infectious diseases of the nervous system. 相似文献
87.
Sheikh-Ismail LI Henry CJ Lightowler HJ Aldhaheri AS Masuadi E Al Hourani HM 《International journal of food sciences and nutrition》2009,60(Z3):26-33
The purpose of this present study was to investigate the prevalence of overweight and obesity in adult females in the United Arab Emirates. A total number of 724 females, age 20-90 years, were recruited from the seven Emirates. The sample was divided into three age groups, 20 to <30 years, 30 to <60 years and >60 years. Height, weight and mid-upper-arm circumference were measured in each subject. Overweight and obesity were defined as a body mass index of 25.0-29.9 kg/m2 and >30 kg/m2, respectively. The prevalence of overweight and obesity were 27% and 16%, respectively. The age group between 30 and <60 years had the highest prevalence of overweight (33%) and obesity (24%). In conclusion, the findings from our study suggest that a high proportion of adult females in the United Arab Emirates are overweight and obese. The consequences of this are a serious concern for public health and need to be addressed. 相似文献
88.
Layla L. de Jonge Lennie van Osch-Gevers Albert Hofman Willem A. Helbing 《Early human development》2010,86(8):463-468
Background
Shorter duration of breastfeeding in infancy has been suggested to be associated with an increased risk of cardiovascular disease in adulthood. Early cardiovascular adaptations due to breastfeeding may explain these associations.Aim
To investigate whether breastfeeding affects left cardiac structures and blood pressure development in early childhood.Study design
Prospective cohort study from fetal life until the age of two years.Subjects
Information about the duration and exclusivity of breastfeeding was collected by questionnaires at the ages of 2, 6 and 12 months in 933 children.Outcome measures
Left cardiac structures (left atrial diameter, aortic root diameter and left ventricular mass), fractional shortening and blood pressure at the ages of 1.5, 6 and 24 months.Results
No differences in cardiac structures, fractional shortening and blood pressure were observed between breastfed and non-breastfed children. Duration and exclusivity of breastfeeding were not consistently associated with any cardiac structure, fractional shortening, or blood pressure until the age of 24 months. Also, there was no association of breastfeeding with cardiac growth between 6 months and 24 months. All analyses were adjusted for child age and sex. Additional adjustment for child anthropometrics, maternal age, anthropometrics, family history, maternal cardiovascular risk factors, pregnancy or delivery complications, parity, socio-economic status, smoking status and alcohol consumption during pregnancy did not materially change the effect estimates.Conclusions
Our results do not support the hypothesis that early postnatal cardiovascular adaptations underlie the previously shown associations between breastfeeding and cardiovascular disease in adulthood. Further studies are needed to investigate whether and at what age the associations appear. 相似文献89.
90.
Clarice C. Veloso Layla D.M. Cabral Danielle F. Dias Roseli Soncini 《Journal of ethnopharmacology》2010,132(1):355-358