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991.
Luis M. Pérez-Belmonte MD PhD Jaime Sanz-Cánovas MD Mercedes Millán-Gómez MD PhD Julio Osuna-Sánchez MD Almudena López-Sampalo MD Michele Ricci MD Manuel Jiménez-Navarro MD PhD Maria D. López-Carmona MD PhD María Rosa Bernal-López PhD Miguel A. Barbancho MD PhD José P. Lara MD PhD Ricardo Gómez-Huelgas MD PhD 《Journal of the American Geriatrics Society》2022,70(3):862-871
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994.
Trends in blood pressure diagnosis,treatment, and control among VA nursing home residents, 2007–2018
995.
Laura Castelnovo Antonio Tamburello Alfredo Lurati Eleonora Zaccara Maria Grazia Marrazza Micol Olivetti Nicola Mumoli Daniela Mastroiacovo Daniele Colombo Elisabetta Ricchiuti Paolo Vigano Faggioli Paola Antonino Mazzone 《Medicine》2021,100(1)
COVID-19 is causing a high influx of patients suffering from serious respiratory complications leading the necessity to find effective therapies. These patients seem to present with cytokine perturbation and high levels of IL6. Tocilizumab and sarilumab could be effective in this condition.We retrospectively collected data about 112 consecutive hospitalized in a single center.Fifty (IL6 group) treated with tocilizumab (8 mg/kg intravenously [IV], 2 infusions 12 hours apart) or sarilumab 400 mg IV once and 62 treated with the standard of care but not anti-cytokine drugs (CONTROL group).To determine whether anti-IL6 drugs are effective in improving prognosis and reducing hospitalization times and mortality in COVID-19 pneumonia.To date 84% (42/50) of IL6 group patients have already been discharged and only 2/50 are still recovered and intubated in intensive care. Six/fifty patients (12%) died: 5/6 due to severe respiratory failure within a framework of severe acute respiratory distress syndrome (ARDS), 1 suffered an acute myocardial infarction, and 1 died of massive pulmonary thromboembolism. There were no adverse treatment events or infectious complications. Compared to the CONTROL group they showed a lower mortality rate (12% versus 43%), for the same number of complications and days of hospitalization.Anti-IL6 drugs seem to be effective in the treatment of medium to severe forms of COVID-19 pneumonia reducing the risk of mortality due to multi-organ failure, acting at the systemic level and reducing inflammation levels and therefore microvascular complications. However, it is essential to identify the best time for treatment, which, if delayed, is rendered useless as well as counterproductive. Further studies and ongoing clinical trials will help us to better define patients eligible as candidates for more aggressive intervention. 相似文献
996.
Silvia Angela Debonis Alberto Bongiovanni Federica Pieri Valentina Fausti Alessandro De Vita Nada Riva Lorena Gurrieri Silvia Vanni Danila Diano Laura Mercatali Toni Ibrahim 《Medicine》2021,100(20)
Rationale:Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that is prevalent among children and adolescents. Surgery is the most important therapeutic approach for IMT and complete resection is recommended. Although 50% of IMTs show anaplastic lymphoma kinase (ALK) rearrangements, crizotinib has proven an effective therapeutic approach. However, the genetic landscape of this tumor is still not fully understood and treatment options are limited, especially in the majority of ALK-negative tumors.Patient concerns:We describe the clinical case of a healthy 18-year-old female in whom a pulmonary nodule was incidentally detectedDiagnoses:Following a small increase in the size of the nodule, the patient underwent both 18FDG-PET/CT and 68Ga-PET/CT, resulting in a suspicion of bronchial hamartoma.Interventions:The patient underwent surgery and a salivary gland-like lung tumor was diagnosed.Outcomes:After surgery, the patient was referred to our cancer center, where a review of the histology slides gave a final diagnosis of ALK-negative lung IMT. Given the histology, it was decided not to administer adjuvant therapy and the patient was placed in a 3-monthly follow-up program. The patient is still disease-free 2 years post-surgery.Lessons:Although there is no standard of care for the treatment of IMT, identifying genomic alterations could help to redefine the management of patients with negative-ALK disease. Our review of the literature on IMT and other kinase fusions revealed, in addition to ALK rearrangements, the potential association of ROS1, NTRK, RET, or PDGFR beta alterations with the tumor. 相似文献
997.
Wang Grace Karimi Neda Willmann Laura Pipicella Joseph Descallar Joseph OConnor Katie Peculis Luiza Leung Yvette Connor Susan Huang Vivian Williams Astrid-Jane 《Digestive diseases and sciences》2022,67(9):4303-4314
Digestive Diseases and Sciences - Women with inflammatory bowel disease (IBD) with poor IBD-specific reproductive knowledge experience more childlessness and fear of IBD medications in pregnancy.... 相似文献
998.
Eberspacher Chiara Ficuccilli Fabrizio Tessieri Laura D’Andrea Vito Lauro Augusto Fralleone Lisa Mascagni Domenico 《Digestive diseases and sciences》2021,66(11):3725-3729
Digestive Diseases and Sciences - Haemorrhoids, a common ailment afflicting mostly Western patients, can produce bothersome symptoms, in particular pain, pruritus, and bleeding. There is a wide... 相似文献
999.
Laura R. Epstein Stella S. Lee Mayumi F. Miller Heather A. Lombardi 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(22)
Technological advances, such as genome editing and specifically CRISPR, offer exciting promise for the creation of products that address public health concerns, such as disease transmission and a sustainable food supply and enable production of human therapeutics, such as organs and tissues for xenotransplantation or recombinant human proteins to treat disease. The Food and Drug Administration recognizes the need for such innovative solutions and plays a key role in bringing safe and effective animal biotechnology products to the marketplace. In this article, we (the Food and Drug Administration/Center for Veterinary Medicine) describe the current state of the science, including advances in technology as well as scientific limitations and considerations for how researchers and commercial developers working to create intentional genomic alterations in animals can work within these limitations. We also describe our risk-based approach and how it strikes a balance between our regulatory responsibilities and the need to get innovative products to market efficiently. We continue to seek input from our stakeholders and hope to use this feedback to improve the transparency, predictability, and efficiency of our process. We think that working together, using appropriate science- and risk-based oversight, is the foundation to a successful path forward. 相似文献
1000.
Feuerstadt Paul Aroniadis Olga C. Svedlund Felicia L. Garcia Mariana Stong Laura Boules Mena Khanna Sahil 《Digestive diseases and sciences》2022,67(7):2763-2770
Digestive Diseases and Sciences - Clinical trials have demonstrated the efficacy of FMT for reduction in CDI recurrences (rCDI), but this treatment and its reporting in the literature has... 相似文献