全文获取类型
收费全文 | 349篇 |
免费 | 20篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 29篇 |
妇产科学 | 5篇 |
基础医学 | 48篇 |
口腔科学 | 92篇 |
临床医学 | 29篇 |
内科学 | 31篇 |
皮肤病学 | 2篇 |
神经病学 | 19篇 |
特种医学 | 10篇 |
外科学 | 42篇 |
综合类 | 3篇 |
一般理论 | 1篇 |
预防医学 | 9篇 |
眼科学 | 1篇 |
药学 | 6篇 |
中国医学 | 1篇 |
肿瘤学 | 41篇 |
出版年
2023年 | 4篇 |
2022年 | 7篇 |
2021年 | 7篇 |
2020年 | 7篇 |
2019年 | 10篇 |
2018年 | 8篇 |
2017年 | 6篇 |
2016年 | 4篇 |
2015年 | 16篇 |
2014年 | 9篇 |
2013年 | 16篇 |
2012年 | 17篇 |
2011年 | 35篇 |
2010年 | 22篇 |
2009年 | 17篇 |
2008年 | 15篇 |
2007年 | 14篇 |
2006年 | 19篇 |
2005年 | 11篇 |
2004年 | 14篇 |
2003年 | 15篇 |
2002年 | 11篇 |
2001年 | 3篇 |
2000年 | 7篇 |
1999年 | 7篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 6篇 |
1993年 | 5篇 |
1992年 | 3篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1986年 | 3篇 |
1985年 | 6篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1974年 | 3篇 |
1973年 | 6篇 |
1972年 | 3篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1963年 | 1篇 |
1961年 | 1篇 |
排序方式: 共有370条查询结果,搜索用时 15 毫秒
61.
62.
Hussein MA Baz R Srkalovic G Agrawal N Suppiah R Hsi E Andresen S Karam MA Reed J Faiman B Kelly M Walker E 《Mayo Clinic proceedings. Mayo Clinic》2006,81(7):889-895
OBJECTIVE: To evaluate the efficacy and safety of adding thalidomide to the pegylated liposomal doxorubicin, vincristine, and decreased-frequency dexamethasone (DVd) regimen for multiple myeloma. PATIENTS AND METHODS: Patients newly diagnosed as having active multiple myeloma and those with relapsed-refractory disease were studied between August 2001 and October 2003. Patients received DVd as previously described. Thalidomide was given at 50 mg/d orally and the dose increased slowly to a maximum of 400 mg/d. At the time of best response, patients received maintenance prednisone, 50 mg orally every other day, and daily thalidomide at the maximum tolerated dose for each patient. The primary end point was the rate of complete responses plus very good partial responses as defined by the European Group for Blood and Marrow Transplantation criteria and the Intergroupe Fran?ais du Myélome, respectively. RESULTS: Of 102 eligible patients, 53 were newly diagnosed as having multiple myeloma, and 49 had been previously treated for multiple myeloma. The complete response plus very good partial response rate was 49% and 45%, with an overall response rate of 87% and 90% for patients with newly diagnosed and previously treated multiple myeloma, respectively. Furthermore, better responses were associated with improved progression-free and overall survival. The most common grade 3 and 4 adverse events were thromboembolic events (25%), peripheral neuropathy (22%), and neutropenia (14%). CONCLUSIONS: The addition of thalidomide to the DVd regimen significantly improves the response rate and quality of responses compared with the DVd regimen alone. This improvement is associated with longer progression-free and overall survival. The rate of observed quality responses is comparable to responses seen with high-dose therapy. 相似文献
63.
64.
65.
Ivan Gornik Jasenka Wagner Vladimir Gašparović Davor Miličić Vesna Degoricija Boško Skorić Olga Gornik Gordan Lauc 《Resuscitation》2014
Cell-free DNA has been associated with outcome in several acute conditions including two reports concerning the outcomes after cardiac arrest that found association of circulating DNA quantities at admission with mortality. The origins of cell-free DNA are primarily necrosis and apoptosis, which in cardiac arrest occur during ischaemia (“no-flow” and “low-flow” period), during reperfusion injury and as a consequence of post-arrest inflammatory response. Respecting the facts that significant cellular damage may occur during the post-arrest period, and that damage might be reduced by mild therapeutic hypothermia, we investigated the prognostic value of cell free DNA at ICU admission and 24 h after admission. 相似文献
66.
Gordan M. Vujanić Meriel E.M. Jenney Haydn Adams Simon M. Meyrick 《Pediatric and developmental pathology》2000,3(1):91-94
We report a case of juxtaposed Wilms' tumor (WT) and cystic nephroma (CN) in a 21-month-old girl which gave rise to radiological
diagnostic difficulty. Preoperative chemotherapy was given, resulting in marked tumor necrosis but the cystic nephroma remained
untouched. Histological examination showed characteristic features of a triphasic WT and a CN; the two lesions were separated
by a thick fibrous capsule. While everybody agrees that WT and cystic partially differentiated nephroblastoma (CPDN) are closely
related, there are two opposite views about their relationship to CN. One is that CN may represent the final step in maturation
of WT and CPDN. Other authors argue that there is no evidence to support this theory but believe CN might have something in
common with nephrogenic rests. We suggest that the two lesions in the present case may have originated from two intralobar
nephrogenic rests, which would strengthen the latter view.
Received November 2, 1998; accepted February 16, 1999. 相似文献
67.
Moncada GC Martin J Fernandez E Vildosola PG Caamano C Caro MJ Mjor IA Gordan VV 《General dentistry》2006,54(5):314-318
This clinical trial sought to evaluate the effectiveness of alternative treatment for replacing amalgam and resin-based composite restorations with marginal defects. The study recruited 66 patients with 271 restorations. Each restoration was assigned randomly to one of five groups: Sealant, Refurbishing, Repair, Replacement, and Untreated. Two clinicians evaluated the restorations according to USPHS/Ryge criteria at baseline (Kappa 0.74) and one year after the treatment (Kappa 0.81). The scoring of the margins improved (from bravo to alfa) after the experimental treatments. None of the treatments showed significant degradation of the margins during the 12-month observation period. 相似文献
68.
Dinka Pavičić Baldani Lana Skrgatic Gordan Zlopasa Saša Kralik Oguic Mislav Herman 《Gynecological endocrinology》2019,35(5):401-405
AbstractThe aim of the study was to investigate whether altered adipose tissue secretion of various adipokines is secondary to obesity, hyperandrogenism, and hyperinsulinemia or intrinsic to polycystic ovary syndrome (PCOS). This cross-sectional study included 151 women diagnosed with PCOS by the Rotterdam criteria and 95 healthy women matched by age, body mass index (BMI), and waist-to-hip ratio (WHR). Clinical, biochemical, and hormonal characteristics were assessed. Serum concentrations of ghrelin and adiponectin were found to be significantly lower and concentrations of leptin and resistin significantly higher in women with PCOS than in healthy women matched by age, BMI, and WHR. A PCOS diagnosis made the largest contribution to predicting serum levels of leptin, adiponectin, resistin, and ghrelin in all stepwise multiple regression models, which included PCOS diagnosis, BMI, WHR, luteinizing hormone, total testosterone, free testosterone and homeostatic model assessment of insulin resistance as independent predictors. Leptin, adiponectin, ghrelin and resistin levels may serve as independent biomarkers for the diagnosis of PCOS. 相似文献
69.
Toma Keser Ivan Gornik Frano Vučković Najda Selak Tamara Pavić Edita Lukić Ivan Gudelj Hrvoje Gašparović Bojan Biočina Therese Tilin Annika Wennerström Satu Männistö Veikko Salomaa Aki Havulinna Wei Wang James F. Wilson Nishi Charutvedi Markus Perola Harry Campbell Gordan Lauc Olga Gornik 《Diabetologia》2017,60(12):2352-2360
Aims/hypothesis
Better understanding of type 2 diabetes and its prevention is a pressing need. Changes in human plasma N-glycome are associated with many diseases and represent promising diagnostic and prognostic biomarkers. Variations in glucose metabolism directly affect glycosylation through the hexosamine pathway but studies of plasma glycome in type 2 diabetes are scarce. The aim of this study was to determine whether plasma protein N-glycome is changed in individuals who are at greater risk of developing type 2 diabetes.Methods
Using a chromatographic approach, we analysed N-linked glycans from plasma proteins in two populations comprising individuals with registered hyperglycaemia during critical illness (increased risk for development of type 2 diabetes) and individuals who stayed normoglycaemic during the same condition: AcuteInflammation (59 cases vs 49 controls) and AcuteInflammation Replication (52 cases vs 14 controls) populations. N-glycome was also studied in individuals from FinRisk (37 incident cases of type 2 diabetes collected at baseline vs 37 controls), Orkney Complex Disease Study (ORCADES; 94 individuals with HbA1c > 6.5% [47.5 mmol/mol] vs 658 controls) and Southall and Brent Revisited (SABRE) cohort studies (307 individuals with HbA1c > 6.5% [47.5 mmol/mol] vs 307 controls).Results
Individuals with increased risk for diabetes type 2 development (AcuteInflammation and AcuteInflammation Replication populations), incident cases of type 2 diabetes collected at baseline (FinRisk population) and individuals with elevated HbA1c (ORCADES and SABRE populations) all presented with increased branching, galactosylation and sialylation of plasma protein N-glycans and these changes were of similar magnitude.Conclusions/interpretation
Increased complexity of plasma N-glycan structures is associated with higher risk of developing type 2 diabetes and poorer regulation of blood glucose levels. Although further research is needed, this finding could offer a potential new approach for improvement in prevention of diabetes and its complications.70.