全文获取类型
收费全文 | 1289篇 |
免费 | 124篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 86篇 |
妇产科学 | 36篇 |
基础医学 | 124篇 |
口腔科学 | 53篇 |
临床医学 | 198篇 |
内科学 | 250篇 |
皮肤病学 | 37篇 |
神经病学 | 58篇 |
特种医学 | 165篇 |
外科学 | 144篇 |
综合类 | 35篇 |
预防医学 | 94篇 |
眼科学 | 25篇 |
药学 | 76篇 |
1篇 | |
中国医学 | 9篇 |
肿瘤学 | 63篇 |
出版年
2023年 | 6篇 |
2022年 | 4篇 |
2021年 | 11篇 |
2020年 | 12篇 |
2019年 | 19篇 |
2018年 | 27篇 |
2017年 | 32篇 |
2016年 | 31篇 |
2015年 | 31篇 |
2014年 | 38篇 |
2013年 | 47篇 |
2012年 | 29篇 |
2011年 | 45篇 |
2010年 | 48篇 |
2009年 | 74篇 |
2008年 | 41篇 |
2007年 | 60篇 |
2006年 | 32篇 |
2005年 | 32篇 |
2004年 | 19篇 |
2003年 | 29篇 |
2002年 | 21篇 |
2001年 | 33篇 |
2000年 | 27篇 |
1999年 | 29篇 |
1998年 | 82篇 |
1997年 | 93篇 |
1996年 | 68篇 |
1995年 | 53篇 |
1994年 | 39篇 |
1993年 | 44篇 |
1992年 | 21篇 |
1991年 | 18篇 |
1990年 | 19篇 |
1989年 | 34篇 |
1988年 | 29篇 |
1987年 | 29篇 |
1986年 | 16篇 |
1985年 | 22篇 |
1984年 | 16篇 |
1983年 | 13篇 |
1982年 | 10篇 |
1981年 | 8篇 |
1980年 | 9篇 |
1978年 | 6篇 |
1977年 | 14篇 |
1976年 | 8篇 |
1942年 | 2篇 |
1909年 | 2篇 |
1908年 | 4篇 |
排序方式: 共有1460条查询结果,搜索用时 15 毫秒
191.
Dercksen MW; Weimar IS; Richel DJ; Breton-Gorius J; Vainchenker W; Slaper- Cortenbach CM; Pinedo HM; von dem Borne AE; Gerritsen WR; van der Schoot CE 《Blood》1995,86(10):3771-3782
In the present study, we show by adhesion assays and ultrastructural studies that platelets can bind to CD34+ cells from human blood and bone marrow and that this interaction interferes with the accurate detection of endogenously expressed platelet glycoproteins (GPs). The interaction between these cells was found to be reversible, dependent on divalent cations, and mediated by P-selectin. Enzymatic characterization showed the involvement of sialic acid residues, protein(s). The demonstration of mRNA for the P-selectin glycoprotein ligand 1 (PSGL-1) in the CD34+ cells by polymerase chain reaction (PCR) analysis suggests that this molecule is present in these cells. Under conditions that prevent platelet adhesion, a small but distinct subpopulation of CD34+ cells diffusely expressed the platelet GPIIb/IIIa complex. These cells were visualized by immunochemical studies. Furthermore, synthesis of mRNA for GPIIb and GPIIIa by CD34+ cells was shown using PCR analysis. The semiquantitative PCR results show relatively higher amounts of GPIIb mRNA than of PF4 mRNA in CD34+CD41+ cells in comparison with this ratio in platelets. This finding is a strong indication that the PCR results are not caused by contaminating adhering platelets. MoAbs against GPIa GPIb alpha, GPV, P- selectin, and the alpha-chain of the vitronectin receptor did not react with CD34+ cells. The number of CD34+ cells expressing GPIIb/IIIa present in peripheral blood stem cell (PBSC) transplants was determined and was correlated with platelet recovery after intensive chemotherapy in 27 patients. The number of CD34+CD41+ cells correlated significantly better with the time of platelet recovery after PBSC transplantation (r = .83, P = .04) than did the total number of CD34+ cells (r = .55). Statistical analysis produced a threshold value for rapid platelet recovery of 0.34 x 10(6) CD34+CD41+ cells/kg. This study suggests that if performed in the presence of EDTA the flow cytometric measurement of GPIIb/IIIa on CD34+ cells provides the most accurate indication of the platelet reconstitutive capacity of the PBSC transplant. 相似文献
192.
CM Smuts HY Tichelaar MA Dhansay M Faber J Smith GF Kirsten 《Acta paediatrica (Oslo, Norway : 1992)》1999,88(7):757-762
This study investigated the effect of alcohol consumption and smoking during pregnancy on the fatty acid composition of the infants. A total of 40 very-low-birth-weight (VLBW) infants, weighing between 750 and 1500 g, were enrolled in the study after being hospitalized and ventilated for respiratory distress syndrome (RDS). Maternal and infant demographic information was recorded. Questions regarding maternal smoking (none, < 10 and > or = 10 cigarettes/d) and alcohol consumption (none, occasionally, moderate and severe) were recorded. Erythrocyte membrane (EMB; n = 40) total fatty acid analyses were performed at birth (baseline) and on days 14 and 28 postnatally. During pregnancy, 42% of mothers consumed alcohol and 50% smoked. At birth, infants of mothers who smoked and consumed alcohol during pregnancy, had significantly higher blood docosahexaenoic acid (DHA; p < 0.05) than infants of mothers who abstained from both alcohol and smoking. The consequences of this finding remain unknown. 相似文献
193.
194.
Hartdorff Caroline M Frank Kneepkens CM van Dijk Alice EM Stok Anita Engels Michelle AH Gemke Reinoud JBJ Kindermann Angelika 《Tijdschrift voor kindergeneeskunde》2013,81(1):11-11
Tijdschrift voor Kindergeneeskunde - 相似文献
195.
Background
We examined the association of alcohol use disorders (AUD) with adherence to and health-related quality of life (HRQOL) outcomes of antiretroviral treatment (ART) for HIV/AIDS patients.Methods
A cross-sectional multi-site survey was conducted in 468 drug users and 648 non-drug users (age: 35.4 ± 7.0 years; 63.8% male) in 3 epicentres of Vietnam. AUD, ART adherence, and HRQOL were measured using the Alcohol Use Disorders Identification Test - Consumption (AUDIT-C), the self-reported Visual Analogue Scale (VAS), and the World Health Organization Quality of Life instrument (WHOQOL-HIV BREF).Results
35.0% of drug users were hazardous drinkers, compared to 25.9% of non-drug users. 22.3% of drug users engaged in binge drinking, and 25.9% reported suboptimal ART adherence. Adjusting for propensity scores of AUD, patients who had either at-risk or binge drinking behaviour were about twice as likely to be treatment non-adherent as those who did not have AUD. Hazardous drinkers reported small to medium decrements in the Performance, Physical, Social, Spirituality, and Environment quality of life domains. Binge drinkers had a slightly higher score in Social dimension.Conclusion
AUD is prevalent and negatively affecting adherence to and HRQOL outcomes of ART services in injection-driven HIV epidemics. Screening and intervention are recommended for AUD, especially during the stable periods of ART. Other social and psychological interventions might also enhance patients’ responses to and outcomes of ART in Vietnam. 相似文献196.
Permanent impairment of embryo development by hydrosalpinges 总被引:6,自引:9,他引:6
Recent reports suggest a deleterious effect of hydrosalpinges on pregnancy
outcome for in-vitro fertilization (IVF) and improvement following surgical
treatment. We compared the effect of hydrosalpinx on pregnancy outcome in
286 patients having 348 IVF cycles and followed the development of
untransferred embryos for 7 days to determine if hydrosalpinges affect
oocyte quality or embryo development. The delivery rate per retrieval was
significantly lower for patients with hydrosalpinx, but was restored by
surgical treatment to that of patients without hydrosalpinx. However, the
implantation rate per embryo transferred and normal blastulation of
untransferred embryos, which were significantly decreased in patients with
hydrosalpinx, and growth arrest and degeneration of untransferred embryos,
which were significantly increased compared to patients without
hydrosalpinx, were not restored by surgical treatment of hydrosalpinges. We
conclude that surgical treatment of hydrosalpinges decreases early
pregnancy loss and improves pregnancy outcome, possibly by diminishing
reversible deleterious effects exerted on the endometrium. As we have seen
in our laboratory, hydrosalpinges may have a permanent negative influence
on ovarian function, follicular development and oocyte quality since
implantation of transferred embryos and normal blastulation of
untransferred embryos remain low, and in-vitro growth arrest and
degeneration remain high despite surgical treatment of hydrosalpinges.
相似文献
197.
198.
199.
200.
Bernard MY Cheung THY Au SY Chan CM Lam SH Lau RP Lee SF Lee WS Lo EHF Sin MY Tang HH Tsang 《Experimental & Clinical Cardiology》2005,10(1):21-24