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排序方式: 共有247条查询结果,搜索用时 15 毫秒
1.
Ciuffolo F Manzoli L D'Attilio M Tecco S Muratore F Festa F Romano F 《European journal of orthodontics》2005,27(6):601-606
The aim of this study was to describe the prevalence and distribution, by gender, of occlusal traits in a sample of Italian students aged 11-14 years (mean 13 +/- 1 years). Using standardized and validated recording criteria, a single operator measured the overjet, overbite, open bite, anterior and posterior crossbites, crowding, coincidence of the upper and lower midlines, and diastema, in 810 secondary school students (53.6 per cent males). Chi-square, t-test statistics, and odds ratios (ORs) with 95 per cent confidence intervals (CI) were used to investigate the relationship between gender and malocclusion characteristic. Logistic regression was used to further analyse the independent association between gender and each outcome measure. Ninety-three per cent of the subjects showed at least one occlusal trait, with one or two anomalies recorded in 63 per cent of children. The prevalence of occlusal traits ranged from 1.1 (negative overjet) to 54 per cent (upper and lower midlines not coincident). Males were more likely than females to show both an increased overbite and an increased overjet, although the latter result was not confirmed by logistic regression (P = 0.05). Multivariate analysis showed a negative association between overbite and misalignment of the lower incisors and lack of coincidence of the upper and lower midlines, whereas subjects with an increased overbite were more likely to have an increased overjet (all P < 0.01). Further studies are required in order to further clarify these findings and to provide accurate estimates of the orthodontic treatment need in Italian adolescents. 相似文献
2.
Alessio-Mazzola Mattia Repetto Ilaria Russo Antonio Clemente Antonio Ventura Niccolò Formica Matteo Burastero Giorgio Felli Lamberto 《HSS journal》2020,16(3):272-279
HSS Journal ® - Peri-prosthetic shoulder infection (PSI), a highly disabling complication of shoulder arthroplasty, often requires additional surgery and prolonged antibiotic therapy. Of... 相似文献
3.
The Italian way to Continuing Education in Medicine 总被引:2,自引:0,他引:2
Pressato L 《Clinica chimica acta; international journal of clinical chemistry》2002,319(2):155-159
BACKGROUND: Continuing education is a right and a duty for all professionals working in the healthcare system, and the Ministry of Health, has recently developed and introduced an experimental program for Continuing Education in Medicine (ECM) throughout Italy. METHODS: The guiding principles and values of ECM are to assure the quality of educational events and to ensure that professionals can choose from among several opportunities for gaining credits. Although promoted by regional healthcare authorities, the educational program must be homogeneous throughout the national territory. RESULTS: Over the last few months, the National Commission for ECM has defined the role and responsibilities of different organisms and authorities involved in the ECM program. Each professional is expected to gain a total score of at least 150 credits over a 5-year timespan. Moreover, the Commission has established criteria for the accreditation of educational initiatives, the verification of their quality, and the evaluation of the educational benefit participants have from them. CONCLUSIONS: The ECM program in Italy is here to stay. It provides professionals with the opportunity to improve the quality of their knowledge, competence, and skills. Medical associations can now reevaluate their role and commitment to improving the quality of healthcare by providing all professionals with a better education and qualifications. 相似文献
4.
Viegi A Cotrufo T Berardi N Mascia L Maffei L 《The European journal of neuroscience》2002,16(10):1925-1930
Total lack of visual experience (dark rearing, DR) is known to affect development of mammalian visual cortex (VC) and to prolong the critical period of visual cortical plasticity. Neurotrophins (NTs) have been proposed to play a relevant role in activity dependent processes important for the final shaping of cortical visual connections. Neurotrophin supply or antagonism of endogenous NT action profoundly affect visual cortical development and plasticity; in particular, exogenous supply of NTs counteracts DR effects on VC development. However, the effects of DR on NT expression are still debated and mounting evidence reports a mismatch between BDNF mRNA and protein expression in DR animals. To gain insight into the effects of DR on expression of nerve growth factor (NGF) and the functional state of NT signalling pathways, we assessed the phosphorylation state of Trk receptors in light-reared animals (LR), in dark-reared animals (DR), in DR animals briefly exposed to light and in DR animals with exogenous supply of NTs [NGF, brain-derived neurotrophic factor (BDNF) and NT-4] in the VC. We report that DR increases the expression of NGF but reduces the phosphorylation of TrkA and TrkB receptors with respect to LR; normal phosphorylation is rapidly rescued by a brief exposure to light. Exogenous supply of NGF, BDNF or NT4 in DR animals also rescues the phosphorylation of their receptors. 相似文献
5.
The role of dietary factors in patients with type 1 (insulin-dependent) diabetes is reviewed by examining three different aspects: the effect of an acute protein load, the effect of dietary protein restriction on the progression of nephropathy and the metabolic effects of low-protein diets. After an acute protein load some impairment of the renal functional reserve may be observed only in patients with type 1 diabetes and overt nephropathy. However, the renal functional reserve is not able to give useful indications of the extent of renal damage and the prognosis of the disease. Both short-term and long-term dietary protein restriction are followed by a significant decrease in glomerular filtration rate (GFR) and albuminuria in type 1 diabetics with incipient nephropathy. In patients with overt nephropathy the long-term administration of a low-protein diet is followed by significant reductions in the rate of decline of GFR and in urinary protein excretion only when started at GFR values higher than 45 ml/min. The rate of functional deterioration when dietary treatment is prescribed seems critical in modulating the effects of a low-protein diet. In addition, low-protein diets may exert important metabolic and clinical effects beyond their supposed effect on progression. Clearly, an adequate dietary regimen is only part of the medical treatment in patients with diabetic nephropathy. 相似文献
6.
Sale A Putignano E Cancedda L Landi S Cirulli F Berardi N Maffei L 《Neuropharmacology》2004,47(5):649-660
Rearing mice from birth in an enriched environment leads to a conspicuous acceleration of visual system development appreciable at behavioral, electrophysiological and molecular level. Little is known about the possible mechanisms of action through which enriched environment affects visual system development. It has been suggested that differences in maternal behavior between enriched and non-enriched conditions could contribute to the earliest effects of enriched environment on visual development and that neurotrophins, BDNF in particular, might be involved. Here, we examined Brain Derived Neurotrophic Factor (BDNF) levels in the visual cortex during development and showed that an increase occurs in the first week of life in enriched pups compared to standard reared pups; BDNF levels at birth were equal in the two groups. This suggests a postnatal rather than a prenatal effect of environment on BDNF. A detailed analysis of maternal care behavior showed that pups raised in a condition of social and physical enrichment experienced higher levels of licking behavior and physical contact compared to standard reared pups and that enhanced levels of licking were also provided to pups in an enriched environment where no adult females other than the mother were present. Thus, different levels of maternal care in different environmental conditions could act as indirect mediator for the earliest effects of enrichment on visual system development. Some of the effects of different levels of maternal care on the offspring behavior are long lasting. We measured the visual acuity of differentially reared mice at the end of the period of visual acuity development (postnatal day 45) and at 12 months of age, using a behavioral discrimination task. We found better learning abilities and higher visual acuity in enriched compared to standard reared mice at both ages. 相似文献
7.
BACKGROUND AND PURPOSE: To determine whether, according to the currently available literature, proton therapy (PT) has a role in the treatment of non-small-cell lung cancer (NSCLC), to assess its safety and efficacy and to evaluate the main technical issues specifically related to this treatment technique. MATERIALS AND METHODS: During March 2007, two independent researchers conducted a systematic review of the current data on the treatment of NSCLC with PT. RESULTS: In total, 113 reports were retrieved, 17 of which were included in the analysis. There were no prospective trials (randomized or non-randomized). Nine uncontrolled single-arm studies were available from three PT centers, providing clinical outcomes for 214 patients in total. These reports were mainly related to stage I-II tumors, with results comparable to those obtained with surgery, without significant toxicity. In addition, two papers were found that compared photon and proton dose distributions, which showed a potential for dose escalation and/or a sparing of the organ at risk with PT. Finally, six studies analyzed dosimetric and technical issues related with PT, mainly underlining the difficulties in designing dose distributions that are representative of the dose actually delivered during treatment. CONCLUSIONS: Although from a physical point of view PT is a good option for the treatment of NSCLC, limited data are available on its application in the clinical practice. Furthermore, the application of PT to lung cancer does present technical challenges. Because of the small number of institutions involved in the treatment of this disease, number of patients, and methodological weaknesses of the trials it is therefore not possible to draw definitive conclusions about the superiority of PT with respect to the photon techniques currently available for the treatment of NSCLC. 相似文献
8.
Endodermal sinus tumor of the omentum: case report 总被引:1,自引:0,他引:1
Geminiani ML Panetta A Pajetta V Bacci F Negri L Maccaferri R Virzì S Ventrucci M 《Tumori》2005,91(6):563-566
We report a case of primary endodermal sinus tumor of the omentum in a 46-year-old woman. The patient had been referred to our hospital for pain in the right abdomen. CT scan revealed a right-sided abdominal mass. At laparotomy, a large omental tumor extending to the bowel, uterus, ovaries and peritoneum was found, and it was totally resected. The tumor displayed the typical histological patterns observed in endodermal sinus tumor, and the immunohistochemical findings confirmed the diagnosis. Serum AFP level was 21.550 ng/ml prior to laparotomy, and decreased to 13.845 ng/mL after surgery, whereas the level of serum beta human chorionic gonadotropin was normal. Post-surgery, the patient received combination chemotherapy consisting of cisplatin, etoposide and bleomycin every 3 weeks for a total of 6 cycles. At the end of the treatment, all the findings, including AFP level, were normal. 相似文献
9.
Alfonso Lagi MD Marcello Cipriani MD Lamberto Fattorini MD Cristiano Paggetti PhD Alberto Macerata PhD 《Clinical autonomic research》1994,4(6):307-309
The arterial baroreflex was studied in subjects who had recently had an episode of vasodepressor syncope. This was determined using 2–3 mcg/kg intravenous boluses of phenylephrine and assessing the bradycardic response. The values were measured in ms/mmHg and expressed as the angular coefficient of the regression line between the increase in R—R interval on the electrocardiograph and the systolic arterial pressure. In subjects examined immediately after the vasodepressor syncope episode the bradycardic response was much more marked than in controls (p < 0.01) and in the subjects themselves 6 months after the episode, provided that they were symptom-free (p < 0.01). It is concluded that in vasodepressor syncope there is a phase in which the baroreflex is highly sensitive and that this is due not to a lowering of the stimulation threshold but to a gain in the efferent arc, which explains a vagotonic response. 相似文献
10.
J. L. Pourriat MD M. Baud MD Ch. Lamberto MD J. L. Fournier MD M. Cupa MD 《Journal of clinical monitoring and computing》1994,10(1):26-34
Objective. Our objective is to present a methodology for the automated acquisition and storage of BP and P0.1 during a CO2 rebreathing test.Methods. The system consists of a microcomputer with additional circuits and an automatic electronically controlled valve to occlude the inspiratory airway. Data collection and data processing are separate programs. Airway pressure and flow are digitized at a 100-Hz rate, whilePetCO2 is determined and P0.1 is measured on a breath-by-breath basis. Off-line processing calculates the BP variables, generates a correlation matrix (Ve/PetCO2,Ttot/PetCO2,Ti/PetCO2,Te/PetCO2, [Vt/Ti]/PetCO2, [Ti/Ttot]/PetCO2, P0.1/PetCO2), and edits graphic data. The accuracy of the volume and pressure measurements was tested by comparing known volumes provided by a syringe (n=100) and a series of pressures controlled by a water manometer (n=41) on the one hand, with volumes and pressures measured by the device. The accuracy of the time intervals and P0.1 was assessed by comparing in 10 healthy subjects the values measured manually on a graphic recording with those provided by the device (n=170).Results. Volumes: Vmeasured=0.99×Vcontrolled,r=0.99,p<0.001. Pressures: Pmeasured=0.97×Pcontrolled+0.09,r=0.98,p<0.001. Inspiratory time:Ti automatic=0.91×Ti graphic+0.22,r=0.93,p<0.001. Expiratory time:Te automatic=0.93×Te graphic+0.34,r=0.95,p<0.001. Occlusion pressure: P0.1 automatic=0.95×P0.1 graphic+0.62,r=0.94,p<0.001. Reproducibility was assumed to be represented by the intraindividual coefficient of variation of the CO2 response. The comparison of an automatic breath-to-breath method with a graphic manual recording revealed significantly less variability with the former (Ve/PetCO2: 15.2±4.5% vs 22.5±6.3%,p<0.01; P0.1/PetCO2: 8.3±4.3% vs 19.7±7.2%,p<0.001; [Vt/Ti]/PetCO2: 9.1±3.5% vs 14.5±5.3%,p<0.05).Conclusion. Our automated acquisition and storage of waveforms and breath-by-breath determination of BP and P0.1 provide an easy and thorough analysis of the respiratory response to CO2 and decrease the variability of the results. 相似文献