全文获取类型
收费全文 | 680篇 |
免费 | 45篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 28篇 |
妇产科学 | 8篇 |
基础医学 | 51篇 |
口腔科学 | 26篇 |
临床医学 | 142篇 |
内科学 | 153篇 |
皮肤病学 | 2篇 |
神经病学 | 27篇 |
特种医学 | 161篇 |
外科学 | 34篇 |
综合类 | 25篇 |
预防医学 | 27篇 |
药学 | 25篇 |
肿瘤学 | 34篇 |
出版年
2023年 | 7篇 |
2022年 | 2篇 |
2021年 | 11篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 7篇 |
2017年 | 6篇 |
2016年 | 11篇 |
2015年 | 5篇 |
2014年 | 16篇 |
2013年 | 25篇 |
2012年 | 15篇 |
2011年 | 20篇 |
2010年 | 26篇 |
2009年 | 46篇 |
2008年 | 19篇 |
2007年 | 17篇 |
2006年 | 11篇 |
2005年 | 15篇 |
2004年 | 6篇 |
2003年 | 16篇 |
2002年 | 11篇 |
2001年 | 13篇 |
2000年 | 15篇 |
1999年 | 11篇 |
1998年 | 40篇 |
1997年 | 38篇 |
1996年 | 37篇 |
1995年 | 35篇 |
1994年 | 23篇 |
1993年 | 25篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 8篇 |
1989年 | 27篇 |
1988年 | 24篇 |
1987年 | 15篇 |
1986年 | 9篇 |
1985年 | 16篇 |
1984年 | 10篇 |
1983年 | 9篇 |
1982年 | 19篇 |
1981年 | 12篇 |
1980年 | 17篇 |
1978年 | 8篇 |
1977年 | 12篇 |
1976年 | 7篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有745条查询结果,搜索用时 781 毫秒
81.
Treatment of progressive Hodgkin's disease with intensive chemoradiotherapy and autologous bone marrow transplantation 总被引:2,自引:0,他引:2
Phillips GL; Wolff SN; Herzig RH; Lazarus HM; Fay JW; Lin HS; Shina DC; Glasgow GP; Griffith RC; Lamb CW 《Blood》1989,73(8):2086-2092
Twenty-six patients with progressive Hodgkin's disease after conventional chemotherapy received intensive chemoradiotherapy and autologous bone marrow transplantation (ABMT); 19 also received additional involved-field radiotherapy. Twenty-one patients [81%, 95% confidence intervals (CI) 61% to 94%] attained complete (n = 18) or partial responses. Ten patients (38%, 95% CI 20% to 59%) are disease- free a median of 4.5 years later (range 3.5 to 7.0 years), including seven patients with continuous complete responses. The likelihood of overall response was not significantly influenced by any clinical or treatment variable examined. However, there was a trend favoring patients with higher Karnofsky scores, and higher scores were associated with attainment of complete responses (P = .06 and P = .02, respectively, Mann-Whitney U test). Both higher Karnofsky scores and shorter durations of disease before transplantation were associated with improved survival in a stepwise Cox multivariate analysis. The chief cause of failure was progression at sites previously involved with Hodgkin's disease. No patient relapsed in the marrow, and two of three patients with a history of marrow involvement with Hodgkin's disease achieved durable complete responses after transplantation. These data suggest that inadequate pretransplant conditioning, and not the reinoculation of occult tumor cells in the autologous marrow, caused most relapses. Fatal treatment-related toxicity occurred in six patients. Three patients died of idiopathic interstitial pneumonitis; each had previously received local mediastinal irradiation before intensive chemoradiotherapy. Intensive chemoradiotherapy and ABMT produces durable responses in some patients with Hodgkin's disease incurable with conventional therapy. Use of such therapies at the first sign of failure with conventional chemotherapy and development of more effective conditioning regimens should further improve results. 相似文献
82.
A clinical study comparing digital radiography and near‐infrared transillumination in caries detection
下载免费PDF全文
![点击此处可从《Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]》网站下载免费的PDF全文](/ch/ext_images/free.gif)
83.
James TF Lai John DC Dereix Ravi P Ganepola Peter G Nightingale Kiera A Markey Paul N Aveyard Alexandra J Sinclair 《The journal of headache and pain》2014,15(1):10
Background
Medication-overuse headache (MOH) is caused by the regular use of medications to treat headache. There has been a lack of research into awareness of MOH. We distributed an electronic survey to undergraduate students and their contacts via social networking sites. Analgesic use, awareness of MOH, perceived change in behaviour following educational intervention about the risks of MOH and preferred terminology for MOH was evaluated.Findings
485 respondents completed the questionnaire (41% having received healthcare training). 77% were unaware of the possibility of MOH resulting from regular analgesic use for headache. Following education about MOH, 80% stated they would reduce analgesic consumption or seek medical advice. 83% indicated that over the counter analgesia should carry a warning of MOH. The preferred terminology for MOH was painkiller-induced headache.Conclusions
This study highlights the lack of awareness of MOH. Improved education about MOH and informative packaging of analgesics, highlighting the risks in preferred lay terminology (i.e. painkiller-induced headache), may reduce this iatrogenic morbidity and warrants further evaluation. 相似文献84.
85.
Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics 总被引:18,自引:8,他引:18
A cell line, designated RS4;11, was established from the bone marrow of a patient in relapse with an acute leukemia that was characterized by the t(4;11) chromosomal abnormality. The cell line and the patient's fresh leukemic cells both had the t(4;11)(q21;q23) and an isochromosome for the long arm of No. 7. Morphologically, all cells were lymphoid in appearance. Ultrastructurally and cytochemically, approximately 30% of the cells possessed myeloid features. The cells were strongly positive for terminal deoxynucleotidyl transferase. They were HLA-DR positive and expressed surface antigens characteristic for B lineage cells, including those detected by anti-B4, BA-1, BA-2, and PI153/3. Immunoglobulin gene analysis revealed rearrangements of the heavy chain and kappa chain genes. The cells lacked the common acute lymphoblastic leukemia antigen and antigenic markers characteristic of T lineage cells. The cells reacted with the myeloid antibody 1G10 but not with other myeloid monoclonal antibodies. Treatment with 12-O-tetradecanoyl- phorbol-13-acetate induced a monocyte-like phenotype demonstrated by cytochemical, functional, immunologic, and electron microscopic studies. The expression of markers of both early lymphoid and early myeloid cells represents an unusual phenotype and suggests that RS4;11 represents a cell with dual lineage capabilities. To our knowledge, RS4;11 is the first cell line established from t(4;11)-associated acute leukemia. 相似文献
86.
Acute leukemia associated with the t(4;11) chromosome rearrangement: ultrastructural and immunologic characteristics 总被引:7,自引:1,他引:7
Parkin JL; Arthur DC; Abramson CS; McKenna RW; Kersey JH; Heideman RL; Brunning RD 《Blood》1982,60(6):1321-1331
The acute leukemia associated with the t(4;11) chromosome rearrangement is characterized by relatively consistent clinical features: occurrence primarily in young individuals, hyperleukocytosis, and poor response to therapy. This study describes the morphological, ultrastructural, and immunologic characteristics of the leukemic cells from ten patients with this type of leukemia. The morphological features of the leukemic blasts vary from lymphoid-appearing to monocytic. Ultrastructurally and cytochemically, some of the lymphoid-appearing blasts possess features of myeloid origin. The immunologic phenotype is characteristically E- SIg- CALLA- BA-1- BA-2+ HLA-DR+ and TdT+. These findings suggest that the t(4;11)-associated acute leukemia represents a proliferation of an early myeloid progenitor cell. 相似文献
87.
88.
89.
Transient leukemoid proliferation of the cytogenetically unbalanced +21 cell line of a constitutional mosaic boy 总被引:1,自引:0,他引:1
A newborn without any signs of Down's syndrome was found to have an acute proliferation that remitted without drug therapy. Chromosomal analysis of blood, bone marrow, and skin cells revealed that the child was a constitutional mosaic with normal cells and a low number of cells in which one no. 21 chromosome was replaced by a probably isochromosome for the no. 21 long arm: 46,XY/46,XY,i(21q). The abnormal cell line of the mosaic appeared to be selectively involved in this proliferation. 相似文献
90.
Effect of recombinant granulocyte colony-stimulating factor on neutrophil kinetics in normal young and elderly humans 总被引:15,自引:3,他引:15
Recombinant granulocyte colony-stimulating factor (G-CSF) was administered to healthy young (n = 32) and elderly (n = 19) volunteers (0 microgram/d, 30 microgram/d, or 300 microgram/d) to determine its effect on neutrophil production, blood kinetics, and tissue migration. Measurements included blood counts (daily), marrow neutrophil pool sizes and neutrophil tissue migration (baseline and day 5), blood kinetics (day 6), and marrow transit time while on drug (days 6 to 14). G-CSF markedly expanded the marrow neutrophil mitotic pool and shortened the transit time of the postmitotic pool (control, mean = 6.4 days; 300 microgram/d, mean = 2.9 d). G-CSF increased neutrophil production without significantly altering blood neutrophil half-life or margination. Compared to control, neutrophil accumulation in skin chambers decreased by about 50% in the 300 microgram/d group in both young and elderly subjects. G-CSF induced neutrophilia by stimulating proliferation of marrow neutrophil precursors and accelerating neutrophil entry into the blood. Decreased neutrophil inflammatory responses measured with the skin chamber technique may be because of the relative immaturity of the circulating cells or to alterations in neutrophil phenotype induced by G-CSF. 相似文献