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201.
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Gatenby RA; Coia LR; Richter MP; Katz H; Moldofsky PJ; Engstrom P; Brown DQ; Brookland R; Broder GJ 《Radiology》1985,156(1):211-214
The role of oxygen in tumor response to therapy has been studied for several decades. We describe a technique that allows in vivo measurement of oxygen in tumors using computed tomography to guide probes. In the evaluation of 16 tumors, oxygen tensions were found to be substantially lower than surrounding tissue and varied nonrandomly. This technique has allowed construction of detailed tumor oxygen level maps. 相似文献
204.
205.
Comparison of intracellular bactericidal activities of human neutrophils and eosinophils 总被引:5,自引:1,他引:4
Eosinophils from a patient with hypereosinophilia were observed to phagocytize radiolabeled E. coli or S. aureus as effectively as neutrophils from a normal control. This was observed at a number of bacteria/cell ratios and a various time intervals following initial challenge and was confirmed by direct microscopic examination. In spite of comparables rates of phagocytosis, the eosinophils were consistently less capable of killing the bacteria. This correlates with an inability of eosinophil peroxidase to catalyze the peroxidase-H2O2-CI--mediated decarboxylation of amino acids; in contrast, both eosinophil and neutrophil peroxidases showed similar capabilities to iodinate protein in vitro. These data are compatible with the importance of the chloride- mediated mechanism in the bactericidal activity of intact phagocytes. 相似文献
206.
Varvara?A?Mouchtouri Sandra?Westacott Gordon?Nichols Tobias?Riemer Mel?Skipp Christopher?LR?Bartlett Jenny?Kremastinou Christos?Hadjichristodoulou the SHIPSAN partnership 《BMC public health》2010,10(1):122
Background
Hygiene inspections on passenger ships are important for the prevention of communicable diseases. The European Union (EU) countries conduct hygiene inspections on passenger ships in order to ensure that appropriate measures have been taken to eliminate potential sources of contamination which could lead to the spread of communicable diseases. This study was implemented within the framework of the EU SHIPSAN project and it investigates the legislation applied and practices of hygiene inspections of passenger ships in the EU Member States (MS) and European Free Trade Association countries. 相似文献207.
Ming-May Lai Chia-Ing Li Sharon LR Kardia Chiu-Shong Liu Wen-Yuan Lin Yih-Dar Lee Pei-Chia Chang Cheng-Chieh Lin 《BMC public health》2010,10(1):429
Background
Although sex differences have been reported for associations between components of metabolic syndrome and inflammation, the question of whether there is an effect modification by sex in the association between inflammation and metabolic syndrome has not been investigated in detail. Therefore, the aim of this study was to compare associations of high sensitivity C-creative protein (hs-CRP) with metabolic syndrome and its components between men and women. 相似文献208.
SH Bø EM Davidsen P Gulbrandsen E Dietrichs G Bovim LJ Stovner & LR White 《Cephalalgia : an international journal of headache》2009,29(3):365-372
Cytokines have been measured in cerebrospinal fluid (CSF) from headache patients [infrequent episodic tension-type headache (TTH) and migraine with or without aura, all during attack, and cervicogenic headache] and compared with levels in pain-free individuals. Both proinflammatory [interleukin (IL)-1β, tumour necrosis factor-α and monocyte chemoattractant protein-1 (MCP-1)] and anti-inflammatory cytokines [IL-1 receptor antagonist (IL-1ra), IL-4, IL-10 and transforming growth factor-β1 (TGF-β1)] were included. There were significant group differences in IL-1ra, TGF-β1 and MCP-1 in episodic TTH and migraine compared with controls, and a significant difference in MCP-1 between cervicogenic headache and migraine with aura. Intrathecal MCP-1 correlated with IL-1ra, IL-10 and TGF-β1 in episodic TTH, and MCP-1 with IL-10 in migraine with aura. Cytokine increases were modest compared with those often accompanying serious neurological conditions, and may represent a mild response to pain. We believe this to be the first comparative study of CSF cytokine levels in connection with headache. 相似文献
209.
LR Brunham 《Clinical genetics》2009,75(1):40-41
Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome
Leitch et al. (2008)
Nature Genetics 40: 443–448 相似文献
Leitch et al. (2008)
Nature Genetics 40: 443–448 相似文献
210.
Amanda Emirandetti Gustavo F Simões Renata G Zanon Alexandre LR Oliveira 《Journal of neuroinflammation》2010,7(1):1-16